Nobel Prize in Chemistry 2020 to Emmanuelle Charpentier
- Created: Wednesday, 07 October 2020 13:54
- Written by Eva-Maria Diehl
UCMR Alumna Emmanuelle Charpentier
Awarded Nobel Prize in Chemisty 2020
Emmanuelle Charpentier, Max Planck Unit for the Science of Pathogens, Berlin, Germany, and Jennifer A. Doudna University of California, Berkeley, USA, receive the Nobel Prize in Chemisty for "developing a method of genome editing".
Emmanuelle Charpentier was one of the first recruited group leaders at the Laboratory for Molecular Infection Medicine Sweden, MIMS, within the Umeå Centre for Microbial Research (UCMR) at Umeå University. During Emmanuelle Charpentier’s studies on Streptococcus pyogenes, she discovered a new molecule, tracrRNA, which together with CRISPR RNA and Cas9 play an important role in activation of the CRISPR-Cas system's defense mechanism in the pathogen Streptococcus pyogenes and other bacteria. She published the finding in 2011 in Nature. In the same year, she initiated a collaboration with Jennifer Doudna. Together, they showed how the bacterial protein Cas9 led by two guide RNAs (crRNA and tracrRNA) can identify targets in invading genes. They also showed how the system can be readily reprogrammed to be applied on any gene - which has proven to be a very versatile gene editing tool. This work was published 2012 in Science.