Publications 2012

Achouiti A, Vogl T, Urban CF, Röhm M, Hommes TJ, van Zoelen MA, Florquin S, Roth J, van 't Veer C, de Vos AF, van der Poll T (2012) Myeloid-related protein-14 contributes to protective immunity in gram-negative pneumonia derived sepsis. PLoS Pathog 8: e1002987

Ahlinder J, Ohrman C, Svensson K, Lindgren P, Johansson A, Forsman M, Larsson P, Sjodin A (2012) Increased knowledge of Francisella genus diversity highlights the benefits of optimised DNA-based assays. BMC Microbiology 12:220

Andersson CD, Karlberg T, Ekblad T, Lindgren AEG, Thorsell AG, Spjut S, Uciechowska U, Niemiec MS, Wittung-Stafshede P, Weigelt J, Elofsson M, Schuler H, Linusson A (2012) Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening. J Med Chem 55: 7706-7718

Andersson M, Bjornham O, Svantesson M, Badandah A, Uhlin BE, Bullitt E (2012) A Structural Basis for Sustained Bacterial Adhesion: Biomechanical Properties of CFA/I Pili. Journal of Molecular Biology 415: 918-928

Arnberg N (2012) Adenovirus receptors: implications for targeting of viral vectors. Trends in Pharmacological Sciences 33: 442-448

Balonova L, Mann BF, Cerveny L, Alley WR, Chovancova E, Forslund AL, Salomonsson EN, Forsberg Å, Damborsky J, Novotny MV, Hernychova L, Stulik J (2012) Characterization of Protein Glycosylation in Francisella tularensis subsp holarctica. Molecular & Cellular Proteomics 11: M111.05016.

Barzegar HR, Nitze F, Sharifi T, Ramstedt M, Tai CW, Malolepszy A, Stobinski L, Wagberg T (2012) Simple Dip-Coating Process for the Synthesis of Small Diameter Single-Walled Carbon Nanotubes-Effect of Catalyst Composition and Catalyst Particle Size on Chirality and Diameter. J Phys Chem C 116: 12232-12239

Bengtsson C, Lindgren AEG, Uvell H, Almqvist F (2012) Design, synthesis and evaluation of triazole functionalized ring-fused 2-pyridones as antibacterial agents. European Journal of Medicinal Chemistry 54: 637-646

Berg L, Niemiec MS, Qian WX, Andersson CD, Wittung-Stafshede P, Ekström F, Linusson A (2012) Similar but Different: Thermodynamic and Structural Characterization of a Pair of Enantiomers Binding to Acetylcholinesterase. Angew Chem-Int Edit 51: 12716-12720

Bjarnsholt T, Hoiby N, Donelli G, Imbert C, Forsberg Å (2012) Understanding biofilms--are we there yet? FEMS Immunol Med Microbiol 65: 125-126

Böhme K, Steinmann R, Kortmann J, Seekircher S, Heroven AK, Berger E, Pisano F, Thiermann T, Wolf-Watz H, Narberhaus F, Dersch P (2012) Concerted actions of a thermo-labile regulator and a unique intergenic RNA thermosensor control Yersinia virulence. PLoS Pathog 8: e1002518

Bröms JE, Meyer L, Lavander M, Larsson P, Sjöstedt A (2012) DotU and VgrG, core components of type VI secretion systems, are essential for Francisella LVS pathogenicity. PLoS One 7: e34639

Bröms JE, Meyer L, Sun K, Lavander M, Sjöstedt A (2012) Unique substrates secreted by the type VI secretion system of Francisella tularensis during intramacrophage infection. PLoS One 7: e50473

Chorell E, Pinkner JS, Bengtsson C, Banchelin TSL, Edvinsson S, Linusson A, Hultgren SJ, Almqvist F (2012) Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study. Bioorganic & Medicinal Chemistry 20: 3128-3142

Chorell E, Pinkner JS, Bengtsson C, Edvinsson S, Cusumano CK, Rosenbaum E, Johansson LBA, Hultgren SJ, Almqvist F (2012) Design and Synthesis of Fluorescent Pilicides and Curlicides: Bioactive Tools to Study Bacterial Virulence Mechanisms. Chemistry-a European Journal 18: 4522-4532

Collin B, Rehnstam-Holm AS, Lindmark B, Pal A, Wai SN, Hernroth B (2012) The origin of Vibrio cholerae influences uptake and persistence in the blue mussel Mytilus edulis Journal of Shellfish Research 31: 87-92

Costa TRD, Amer AAA, Fällman M, Fahlgren A, Francis MS (2012) Coiled-coils in the YopD translocator family: A predicted structure unique to the YopD N-terminus contributes to full virulence of Yersinia pseudotuberculosis. Infection Genetics and Evolution 12: 1729-1742

Davidson MB, Katou Y, Keszthelyi A, Sing TL, Xia T, Ou JW, Vaisica JA, Thevakumaran N, Marjavaara L, Myers CL, Chabes A, Shirahige K, Brown GW (2012) Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype. Embo Journal 31: 895-907

Dicks MDJ, Spencer AJ, Edwards NJ, Wadell G, Bojang K, Gilbert SC, Hill AVS, Cottingham MG (2012) A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity. Plos One 7: e40385

Edgren T, Forsberg Å, Rosqvist R, Wolf-Watz H (2012) Type III secretion in Yersinia: injectisome or not? PLoS Pathog 8: e1002669

Ehlers P, Silander I, Wang J, Axner O (2012) Fiber-laser-based noise-immune cavity-enhanced optical heterodyne molecular spectrometry instrumentation for Doppler-broadened detection in the 10(-12) cm(-1) Hz(-1/2) region. Journal of the Optical Society of America B-Optical Physics 29: 1305-1315

Elbir H, Gimenez G, Robert C, Bergström S, Cutler S, Raoult D, Drancourt M (2012) Complete Genome Sequence of Borrelia crocidurae. Journal of Bacteriology 194: 3723-3724

Eneslatt K, Normark M, Bjork R, Rietz C, Zingmark C, Wolfraim LA, Stoven S, Sjostedt A (2012) Signatures of T Cells as Correlates of Immunity to Francisella tularensis. Plos One 7: e32367

Enquist PA, Gylfe A, Hagglund U, Lindstom P, Norberg-Scherman H, Sundin C, Elofsson M (2012) Derivatives of 8-hydroxyquinoline-antibacterial agents that target intra- and extracellular Gram-negative pathogens. Bioorganic & Medicinal Chemistry Letters 22: 3550-3553

Eriksson J, Grundström C, Sauer-Eriksson AE, Sauer UH, Wolf-Watz H, Elofsson M (2012) Small molecule screening for inhibitors of the YopH phosphatase of Yersinia pseudotuberculosis. Adv Exp Med Biol 954: 357-363

Fineran PC, Charpentier E (2012) Memory of viral infections by CRISPR-Cas adaptive immune systems: acquisition of new information. Virology 434: 202-209

Forthal DN, Phan TB, Slepenkin AV, Landucci G, Chu H, Elofsson M, Peterson E (2012) In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds. International journal of antimicrobial agents 40: 354-360

Frost S, Ho O, Login FH, Weise CF, Wolf-Watz H, Wolf-Watz M (2012) Autoproteolysis and intramolecular dissociation of Yersinia YscU precedes secretion of its C-terminal polypeptide YscU(CC). PLoS One 7: e49349

Gabrielsen M, Beckham KSH, Feher VA, Zetterstrom CE, Wang D, Muller S, Elofsson M, Amaro RE, Byron O, Roe AJ (2012) Structural Characterisation of Tpx from Yersinia pseudotuberculosis Reveals Insights into the Binding of Salicylidene Acylhydrazide Compounds. Plos One 7: e32217

Garcia-Aljaro C, Melado-Rovira S, Milton DL, Blanch AR (2012) Quorum-sensing regulates biofilm formation in Vibrio scophthalmi. Bmc Microbiology 12: 287

Gyuranecz M, Birdsell DN, Splettstoesser W, Seibold E, Beckstrom-Sternberg SM, Makrai L, Fodor L, Fabbi M, Vicari N, Johansson A, Busch JD, Vogler AJ, Keim P, Wagner DM (2012) Phylogeography of Francisella tularensis subsp holarctica, Europe. Emerging Infectious Diseases 18: 290-293

Hammer ND, McGuffie BA, Zhou YZ, Badtke MP, Reinke AA, Brannstrom K, Gestwicki JE, Olofsson A, Almqvist F, Chapman MR (2012) The C-Terminal Repeating Units of CsgB Direct Bacterial Functional Amyloid Nucleation. Journal of Molecular Biology 422: 376-389

Hedberg ME, Moore ERB, Svensson-Stadler L, Horstedt P, Baranoy V, Hernell O, Wai SN, Hammarstrom S, Hammarstrom ML (2012). Lachnoanaerobaculum gen. nov., a new genus in the Lachnospiraceae: characterization of Lachnoanaerobaculum umeaense gen. nov., sp nov., isolated from the human small intestine, and Lachnoanaerobaculum orale sp nov., isolated from saliva, and reclassification of Eubacterium saburreum (Prevot 1966) Holdeman and Moore 1970 as Lachnoanaerobaculum saburreum comb. nov. International Journal of Systematic and Evolutionary Microbiology 62: 2685-2690

Hillgren JM, Öberg CT, Elofsson M (2012) Syntheses of pseudoceramines A-D and a new synthesis of spermatinamine, bromotyrosine natural products from marine sponges. Organic & Biomolecular Chemistry 10: 1246-1254

Hogg M, Sauer-Eriksson AE, Johansson E (2012) Promiscuous DNA synthesis by human DNA polymerase theta. Nucleic Acids Research 40: 2611-2622

Honn M, Lindgren H, Sjöstedt A (2012) The role of MglA for adaptation to oxidative stress of Francisella tularensis LVS. BMC Microbiology 12: 14

Horvath I, Weise CF, Andersson EK, Chorell E, Sellstedt M, Bengtsson C, Olofsson A, Hultgren SJ, Chapman M, Wolf-Watz M, Almqvist F, Wittung-Stafshede P (2012) Mechanisms of Protein Oligomerization: Inhibitor of Functional Amyloids Templates alpha-Synuclein Fibrillation. Journal of the American Chemical Society 134: 3439-3444

Hosseinzadeh A, Messer PK, Urban CF (2012) Stable Redox-Cycling Nitroxide Tempol Inhibits NET Formation. Front Immunol 3: 391

Ishikawa T, Sabharwal D, Bröms J, Milton DL, Sjostedt A, Uhlin BE, Wai SN (2012) Pathoadaptive Conditional Regulation of the Type VI Secretion System in Vibrio cholerae O1 Strains. Infection and Immunity 80: 575-584

Ito Y, Vela JL, Matsumura F, Hoshino H, Tyznik A, Lee H, Girardi E, Zajonc DM, Kobayashi M, Bao X, Borén T, Jin R, Seeberger PH, Nakayama J, Kronenberg M, Fukuda M (2012) Helicobacter pylori cholesteryl alpha-glucosides are critical for bacterial growthand activation of invariant NKT cells. Glycobiology 22: 1635-1636

Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E (2012) A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science 337: 816-821

Klinth JE, Castelain M, Uhlin BE, Axner O (2012) The Influence of pH on the Specific Adhesion of P Piliated Escherichia coli. Plos One 7: 8

Klinth JE, Pinkner JS, Hultgren SJ, Almqvist F, Uhlin BE, Axner O (2012) Impairment of the biomechanical compliance of P pili: a novel means of inhibiting uropathogenic bacterial infections? European Biophysics Journal with Biophysics Letters 41: 285-295

Landstrom J, Persson K, Rademacher C, Lundborg M, Wakarchuk W, Peters T, Widmalm G (2012) Small molecules containing hetero-bicyclic ring systems compete with UDP-Glc for binding to WaaG glycosyltransferase. Glycoconjugate J 29: 491-502

Le Rhun A, Charpentier E (2012) Small RNAs in streptococci. RNA Biology 9: 414-426

Lindell K, Fahlgren A, Hjerde E, Willassen NP, Fällman M, Milton DL (2012) Lipopolysaccharide O-antigen prevents phagocytosis of Vibrio anguillarum by rainbow trout (Oncorhynchus mykiss) skin epithelial cells. PLoS One 7: e37678

Liu J, Thanikkal EJ, Obi IR, Francis MS (2012) Elevated CpxR similar to P levels repress the Ysc-Yop type III secretion system of Yersinia pseudotuberculosis. Research in Microbiology 163: 518-530

Loh E, Memarpour F, Vaitkevicius K, Kallipolitis BH, Johansson J, Sonden B (2012) An unstructured 5'-coding region of the prfA mRNA is required for efficient translation. Nucleic Acids Research 40: 1818-1827

Meinzer U, Barreau F, Esmiol-Welterlin S, Jung C, Villard C, Leger T, Ben-Mkaddem S, Berrebi D, Dussaillant M, Alnabhani Z, Roy M, Bonacorsi S, Wolf-Watz H, Perroy J, Ollendorff V, Hugot JP (2012) Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction. Cell Host Microbe 11: 337-51

Moren B, Shah C, Howes MT, Schieber NL, McMahon HT, Parton RG, Daumke O, Lundmark R (2012) EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization. Molecular Biology of the Cell 23: 1316-1329

Nakao R, Ramstedt M, Wai SN, Uhlin BE (2012) Enhanced biofilm formation by Escherichia coli LPS mutants defective in Hep biosynthesis. PLoS One 7: e51241

Napier BA, Meyer L, Bina JE, Miller MA, Sjöstedt A, Weiss DS (2012) Link between intraphagosomal biotin and rapid phagosomal escape in Francisella. Proceedings of the National Academy of Sciences of the United States of America 109: 18084-18089

Netterling S, Vaitkevicius K, Nord S, Johansson J (2012) A Listeria monocytogenes RNA helicase essential for growth and ribosomal maturation at low temperatures Uses Its C terminus for appropriate interaction with the ribosome. J Bacteriol 194: 4377-4385

Neu U, Hengel H, Blaum BS, Schowalter RM, Macejak D, Gilbert M, Wakarchuk WW, Imamura A, Ando H, Kiso M, Arnberg N, Garcea RL, Peters T, Buck CB, Stehle T (2012) Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection. Plos Pathogens 8: e1002738

Öberg CT, Strand M, Andersson EK, Edlund K, Nam Phuong Nguyen T, Mei Y-F, Wadell G, Elofsson M (2012) Synthesis, Biological Evaluation, and Structure-Activity Relationships of 2 2-(Benzoylamino)benzoylamino benzoic Acid Analogues as Inhibitors of Adenovirus Replication. J Med Chem 55: 3170-3181

Paracuellos P, Öhman A, Sauer-Eriksson AE, Uhlin BE (2012) Expression and purification of SfaX(II), a protein involved in regulating adhesion and motility genes in extraintestinal pathogenic Escherichia coli. Protein Expression and Purification 86: 127-134

Persson K, Esberg A, Claesson R, Stromberg N (2012) The Pilin Protein FimP from Actinomyces oris: Crystal Structure and Sequence Analyses. Plos One 7: 10

Pohjala L, Uvell H, Hakala E, Gylfe A, Elofsson M, Vuorela P (2012) The isoflavone biochanin a inhibits the growth of the intracellular bacteria Chiamydia trachomatis and Chlamydia pneumoniae. Planta Medica 78: 1102-1102

Poli J, Tsaponina O, Crabbe L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A, Pasero P (2012) dNTP pools determine fork progression and origin usage under replication stress. Embo Journal 31: 883-894

Revill J, Carnevali MD, Forsberg Å, Holmstrom A, Rath J, Shinwari ZK, Mancini GM (2012) Lessons learned from implementing education on dual-use in Austria, Italy, Pakistan and Sweden. Med Confl Surviv 28: 31-44

Rompikuntal PK, Thay B, Khan MK, Alanko J, Penttinen A-M, Asikainen S, Wai SN, Oscarsson J (2012) Perinuclear Localization of Internalized Outer Membrane Vesicles Carrying Active Cytolethal Distending Toxin from Aggregatibacter actinomycetemcomitans. Infection and Immunity 80: 31-42

Ryden P, Bjork R, Schafer ML, Lundstrom JO, Petersen B, Lindblom A, Forsman M, Sjöstedt A, Johansson A (2012) Outbreaks of Tularemia in a Boreal Forest Region Depends on Mosquito Prevalence. Journal of Infectious Diseases 205: 297-304

Salzer J, Hallmans G, Nystrom M, Stenlund H, Wadell G, Sundstrom P (2012) Vitamin D as a protective factor in multiple sclerosis. Neurology 79: 2140-2145

Sanchez A, Sharma S, Rozenzhak S, Roguev A, Krogan NJ, Chabes A, Russell P (2012) Replication Fork Collapse and Genome Instability in a Deoxycytidylate Deaminase Mutant. Molecular and Cellular Biology 32: 4445-4454

Sandholm K, Henningsson AJ, Bergström S, Ernerudh J, Ekdahl KN (2012) Complement activation and phagocytosis in vitro of two strains of Borrelia burgdorferi S.L. Immunobiology 217: 1153-1153

Sellstedt M, Prasad GK, Krishnan KS, Almqvist F (2012) Directed diversity-oriented synthesis. Ring-fused 5-to 10-membered rings from a common peptidomimetic 2-pyridone precursor. Tetrahedron Letters 53: 6022-6024

Silander I, Ehlers P, Wang J, Axner O (2012) Frequency modulation background signals from fiber-based electro optic modulators are caused by crosstalk. Journal of the Optical Society of America B-Optical Physics 29: 916-923

Skogman BH, Hellberg S, Ekerfelt C, Jenmalm MC, Forsberg P, Ludvigsson J, Bergström S, Ernerudh J (2012) Adaptive and Innate Immune Responsiveness to Borrelia burgdorferi sensu lato in Exposed Asymptomatic Children and Children with Previous Clinical Lyme Borreliosis. Clin Dev Immunol 2012: 10

Strand M, Islam K, Edlund K, Öberg CT, Allard A, Bergstrom T, Mei Y-F, Elofsson M, Wadell G (2012) 2- 4,5-Difluoro-2-(2-Fluorobenzoylamino)-Benzoylamino Benzoic Acid, an Antiviral Compound with Activity against Acyclovir-Resistant Isolates of Herpes Simplex Virus Types 1 and 2. Antimicrobial Agents and Chemotherapy 56: 5735-5743

Svensson K, Sjodin A, Bystrom M, Granberg M, Brittnacher MJ, Rohmer L, Jacobs MA, Sims-Day EH, Levy R, Zhou Y, Hayden HS, Lim R, Chang J, Guenthener D, Kang A, Haugen E, Gillett W, Kaul R, Forsman M, Larsson P , Johansson A. (2012) Genome Sequence of Francisella tularensis subspecies holarctica Strain FSC200, Isolated from a Child with Tularemia. Journal of Bacteriology 194: 6965-6966

Thanikkal EJ, Mangu JCK, Francis MS (2012) Interactions of the CpxA sensor kinase and cognate CpxR response regulator from Yersinia pseudotuberculosis. BMC research notes 5: 536-536

Thein M, Bonde M, Bunikis I, Denker K, Sickmann A, Bergström S, Benz R (2012) DipA, a Pore-Forming Protein in the Outer Membrane of Lyme Disease Spirochetes Exhibits Specificity for the Permeation of Dicarboxylates. Plos One 7: 12

Twine S, Shen H, Harris G, Chen W, Sjöstedt A, Ryden P, Conlan W (2012) BALB/c mice, but not C57BL/6 mice immunized with a DeltaclpB mutant of Francisella tularensis subspecies tularensis are protected against respiratory challenge with wild-type bacteria: association of protection with post-vaccination and post-challenge immune responses. Vaccine 30: 3634-45

Twine SM, Vinogradov E, Lindgren H, Sjöstedt A, Conlan JW (2012) Roles for wbtC, wbtI, and kdtA Genes in Lipopolysaccharide Biosynthesis, Protein Glycosylation, Virulence, and Immunogenicity in Francisella tularensis2 Strain SCHU S4. Pathogens 1: 12-29

Ur-Rehman T, Nordfelth R, Blomgren A, Zetterström CE, Elofsson M, Gylfe A (2012) Preliminary Pharmacokinetics of the Bacterial Virulence Inhibitor N '-(3,5-Dibromo-2-HydroxyBenzylidenene)-Nicotinic Acid Hydrazide. In Advances in Yersinia Research, DeAlmeida AMP, Leal NC (eds) pp 349-356.

Ur-Rehman T, Slepenkin A, Chu H, Blomgren A, Dahlgren MK, Zetterström CE, Peterson EM, Elofsson M, Gylfe A (2012) Pre-clinical pharmacokinetics and anti-chlamydial activity of salicylidene acylhydrazide inhibitors of bacterial type III secretion. Journal of Antibiotics 65: 397-404

Urban CF, Reichenbach J, Bianchi M, Niemiec MJ (2012) Neutrophil extracellular traps in opportunistic mycoses. Mycoses 55: 24-24

Valeru SP, Wai SN, Saeed A, Sandstrom G, Abd H (2012) ToxR of Vibrio cholerae affects biofilm, rugosity and survival with Acanthamoeba castellanii. BMC research notes 5: 33-33

Wang J, Ehlers P, Silander I, Axner O (2012) Speed-dependent effects in dispersion mode of detection and in noise-immune cavity-enhanced optical heterodyne molecular spectrometry: experimental demonstration and validation of predicted line shape. Journal of the Optical Society of America B-Optical Physics 29: 2980-2989

Wang JY, Ehlers P, Silander I, Westberg J, Axner O (2012) Speed-dependent Voigt dispersion line-shape function: applicable to techniques measuring dispersion signals. Journal of the Optical Society of America B-Optical Physics 29: 2971-2979

Westberg J, Wang J, Axner O (2012) Fast and non-approximate methodology for calculation of wavelength-modulated Voigt lineshape functions suitable for real-time curve fitting. Journal of Quantitative Spectroscopy & Radiative Transfer 113: 2049-2057

Westermark L, Fahlgren A, Fällman M (2012) Immune response to diphtheria toxin-mediated depletion complicates the use of the CD11c-DTRtg model for studies of bacterial gastrointestinal infections. Microbial Pathogenesis 53: 154-161

Westermark L, Fahlgren A, Fällman M (2012) Immune response to diphtheria toxin-mediated depletion complicates the use of the CD11c-DTRtg model for studies of bacterial gastrointestinal infections. Immunology 137: 271-271

Widerstrom M, Wistrom J, Sjöstedt A, Monsen T (2012) Coagulase-negative staphylococci: update on the molecular epidemiology and clinical presentation, with a focus on Staphylococcus epidermidis and Staphylococcus saprophyticus. European Journal of Clinical Microbiology & Infectious Diseases 31: 7-20

Zakrisson J, Wiklund K, Axner O, Andersson M (2012) Helix-like biopolymers can act as dampers of force for bacteria in flows. European Biophysics Journal with Biophysics Letters 41: 551-560

Zhou Y, Smith D, Leong BJ, Brannstrom K, Almqvist F, Chapman MR (2012) Promiscuous Cross-seeding between Bacterial Amyloids Promotes Interspecies Biofilms. Journal of Biological Chemistry 287: 35092-35103

Akram N, Palovaara J, Forsberg J, Lindh MV, Milton DL, Luo H, Gonzalez JM, Pinhassi J (2013) Regulation of proteorhodopsin gene expression by nutrient limitation in the marine bacterium Vibrio sp AND4. Environmental Microbiology 15: 1400-1415