Publications 2010

Andersson CD, Chen BY, Linusson A (2010) Mapping of ligand-binding cavities in proteins. Proteins 78: 1408-1422

Andersson CD, Chen BY, Linusson A (2010) Multivariate assessment of virtual screening experiments. J Chemometr 24: 757-767

Andersson EK, Mei YF, Wadell G (2010) Adenovirus interactions with CD46 on transgenic mouse erythrocytes. Virology 402: 20-25

Andersson EK, Strand M, Edlund K, Lindman K, Enquist PA, Spjut S, Allard A, Elofsson M, Mei YF, Wadell G (2010) Small-Molecule Screening Using a Whole-Cell Viral Replication Reporter Gene Assay Identifies 2-{ 2-(Benzoylamino)Benzoyl Amino}-Benzoic Acid as a Novel Antiadenoviral Compound. Antimicrobial Agents and Chemotherapy 54: 3871-3877

Andersson H, Banchelin TS, Das S, Olsson R, Almqvist F (2010) Efficient, mild and completely regioselective synthesis of substituted pyridines. Chemical Communications 46: 3384-3386

Andersson H, Banchelin TSL, Das S, Gustafsson M, Olsson R, Almqvist F (2010) Complete Regioselective Addition of Grignard Reagents to Pyrazine N-Oxides, Toward an Efficient Enantioselective Synthesis of Substituted Piperazines. Organic Letters 12: 284-286

Andersson H, Das S, Gustafsson M, Olsson R, Almqvist F (2010) Synthesis of substituted 4-pyridones and 4-aminopyridinium salts via a one-pot pyridine synthesis. Tetrahedron Letters 51: 4218-4220

Andersson IE, Batsalova T, Dzhambazov B, Edvinsson L, Holmdahl R, Kihlberg J, Linusson A (2010) Oxazole-modified glycopeptides that target arthritis-associated class II MHC A(q) and DR4 proteins. Organic & Biomolecular Chemistry 8: 2931-2940

Axner O, Bjornham O, Castelain M, Koutris E, Schedin S, Fallman E, Andersson M (2010) Unraveling the Secrets of Bacterial Adhesion Organelles Using Single-Molecule Force Spectroscopy. In Single Molecule Spectroscopy in Chemistry, Physics and Biology, Graslund A, Rigler R, Widengren J (eds) pp 337-362.

Barcena-Uribarri I, Thein M, Sacher A, Bunikis I, Bonde M, Bergström S, Benz R (2010) P66 porins are present in both Lyme disease and relapsing fever spirochetes: a comparison of the biophysical properties of P66 porins from six Borrelia species. Biochim Biophys Acta 1798: 1197-1203

Bengtsson C, Almqvist F (2010) Regioselective Halogenations and Subsequent Suzuki-Miyaura Coupling onto Bicyclic 2-Pyridones. Journal of Organic Chemistry 75: 972-975

Bergström S, Zückert  WR (2010) Structure, function and biogenesis of the Borrelia cell envelope. In Borrelia, Molecular Biology, Host Interactions and Pathogenesis Eds DS Samuels and JD Radolf, pp 139-166. Norfolk, UK: Caister Academic Press

Bjornham O, Axner O (2010) Catch-Bond Behavior of Bacteria Binding by Slip Bonds. Biophysical Journal 99: 1331-1341

Brady LJ, Maddocks SE, Larson MR, Forsgren N, Persson K, Deivanayagam CC, Jenkinson HF (2010) The changing faces of Streptococcus antigen I/II polypeptide family adhesins. Molecular Microbiology 77: 276-286

Bröms JE, Sjöstedt A, Lavander M (2010) The role of the Francisella tularensis pathogenicity island in type VI secretion, intracellular survival, and modulation of host cell signaling. Front Microbiol 1: 136

Chen T, Lundin E, Grankvist K, Zeleniuch-Jacquotte A, Wulff M, Afanasyeva Y, Schock H, Johansson R, Lenner P, Hallmans G, Wadell G, Toniolo P, Lukanova A (2010) Maternal hormones during early pregnancy: a cross-sectional study. Cancer Causes & Control 21: 719-727

Chen TH, Lukanova A, Grankvist K, Zeleniuch-Jacquotte A, Wulff M, Johansson R, Schock H, Lenner P, Hallmans G, Wadell G, Toniolo P, Lundin E (2010) IGF-I during primiparous pregnancy and maternal risk of breast cancer. Breast Cancer Research and Treatment 121: 169-175

Chorell E, Edvinsson S, Almqvist F (2010) Improved procedure for the enantioselective synthesis of dihydrooxazolo and dihydrothiazolo ring-fused 2-pyridones. Tetrahedron Letters 51: 2461-2463

Chorell E, Pinkner JS, Phan G, Edvinsson S, Buelens F, Remaut H, Waksman G, Hultgren SJ, Almqvist F (2010) Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity. J Med Chem 53: 5690-5695

Chu H, Slepenkin A, Elofsson M, Keyser P, de la Maza LM, Peterson EM (2010) Candidate vaginal microbicides with activity against Chlamydia trachomatis and Neisseria gonorrhoeae. International journal of antimicrobial agents 36: 145-150

Conlan JW, Shen H, Golovliov I, Zingmark C, Oyston PC, Chen W, House RV, Sjöstedt A (2010) Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization. Vaccine 28: 1824-1831

Costa TR, Edqvist PJ, Bröms JE, Ahlund MK, Forsberg Å, Francis MS (2010) YopD self-assembly and binding to LcrV facilitate type III secretion activity by Yersinia pseudotuberculosis. J Biol Chem 285: 25269-25284

Cupelli K, Muller S, Persson BD, Jost M, Arnberg N, Stehle T (2010) Structure of Adenovirus Type 21 Knob in Complex with CD46 Reveals Key Differences in Receptor Contacts among Species B Adenoviruses. Journal of Virology 84: 3189-3200

Dahlgren MK, Öberg CT, Wallin EA, Janson PG, Elofsson M (2010) Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides. Molecules 15: 4423-4438

Dahlgren MK, Zetterstrom CE, Gylfe A, Linusson A, Elofsson M (2010) Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia. Bioorganic & Medicinal Chemistry 18: 2686-2703

Debruyne L, Broman T, Bergström S, Olsen B, On SLW, Vandamme P (2010) Campylobacter volucris sp nov., isolated from black-headed gulls (Larus ridibundus). International Journal of Systematic and Evolutionary Microbiology 60: 1870-1875

Elfving K, Olsen B, Bergström S, Waldenström J, Lundkvist A, Sjöstedt A, Mejlon H, Nilsson K (2010) Dissemination of spotted fever rickettsia agents in Europe by migrating birds. PLoS One 5: e8572

Engström P, Bailey L, Onskog T, Bergström S, Johansson J (2010) A comparative study of RNA and DNA as internal gene expression controls early in the developmental cycle of Chlamydia pneumoniae. FEMS Immunol Med Microbiol 58: 244-253

Fasullo M, Tsaponina O, Sun MZ, Chabes A (2010) Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants. Nucleic Acids Research 38: 1195-1203

Foltynowicz A, Wang JY, Ehlers P, Axner O (2010) Distributed-feedback-laser-based NICE-OHMS in the pressure-broadened regime. Optics Express 18: 18580-18591

Forsgren N, Lamont RJ, Persson K (2010) Two Intramolecular Isopeptide Bonds are Identified in the Crystal Structure of the Streptococcus gordonii SspB C-terminal Domain. Journal of Molecular Biology 397: 740-751

Forslund AL, Salomonsson EN, Golovliov I, Kuoppa K, Michell S, Titball R, Oyston P, Noppa L, Sjöstedt A, Forsberg Å (2010) The type IV pilin, PilA, is required for full virulence of Francisella tularensis subspecies tularensis. BMC Microbiol 10: 227

Gabrielsen M, Zetterstrom CE, Wang D, Beckham KSH, Elofsson M, Isaacs NW, Roe AJ (2010) Expression, purification, crystallization and initial X-ray diffraction analysis of thiol peroxidase from Yersinia pseudotuberculosis. Acta Crystallographica Section F-Structural Biology and Crystallization Communications 66: 1606-1609

Gautrot J, Huck W, Welch M, Ramstedt M (2010) Protein-Resistant NTA-Functionalized Polymer Brushes for Selective and Stable Immobilization of Histidine-Tagged Proteins. Acs Applied Materials & Interfaces 2: 193-202

Gekara NO, Zietara N, Geffers R, Weiss S (2010) Listeria monocytogenes Induces T Cell Receptor Unresponsiveness through Pore-Forming Toxin Listeriolysin O. Journal of Infectious Diseases 202: 1698-1707

Gomez-Consarnau L, Akram N, Lindell K, Pedersen A, Neutze R, Milton DL, Gonzalez JM, Pinhassi J (2010) Proteorhodopsin Phototrophy Promotes Survival of Marine Bacteria during Starvation. Plos Biology 8: 10

Gripenland J, Netterling S, Loh E, Tiensuu T, Toledo-Arana A, Johansson J (2010) RNAs: regulators of bacterial virulence. Nat Rev Microbiol 8: 857-866

Hillgren JM, Dahlgren MK, To TM, Elofsson M (2010) Synthesis of 4-(2-Hydroxyphenyl)thiazol-2-yl methanones as Potential Bioisosteres of Salicylidene Acylhydrazides. Molecules 15: 6019-6034

Howes MT, Kirkham M, Riches J, Cortese K, Walser PJ, Simpson F, Hill MM, Jones A, Lundmark R, Lindsay MR, Hernandez-Deviez DJ, Hadzic G, McCluskey A, Bashir R, Liu L, Pilch P, McMahon H, Robinson PJ, Hancock JF, Mayor S et al. (2010) Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. J Cell Biol 190: 675-91

Hultdin UW, Lindberg S, Grundström C, Allgardsson A, Huang SH, Stier G, Öhman A, Uhlin BE, Sauer-Eriksson AE (2010) Purification, crystallization and preliminary data analysis of FocB, a transcription factor regulating fimbrial adhesin expression in uropathogenic Escherichia coli. Acta Crystallographica Section F-Structural Biology and Crystallization Communications 66: 337-341

Hultdin UW, Lindberg S, Grundstrom C, Huang SH, Uhlin BE, Sauer-Eriksson AE (2010) Structure of FocB - a member of a family of transcription factors regulating fimbrial adhesin expression in uropathogenic Escherichia coli. Febs Journal 277: 3368-3381

Keszthelyi A, Chabes A (2010) Altered ribonucleotide reductase (RNR) activity in yeast superoxide dismutase 1 (SOD1) deletion mutant. Febs Journal 277: 183-183

Kumar D, Abdulovic AL, Viberg J, Nilsson AK, Kunkel TA, Chabes A (2010) dNTP pool imbalances: Mechanism of mutagenesis and effects on cell cycle. Febs Journal 277: 187-187

Kumar D, Viberg J, Nilsson AK, Chabes A (2010) Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint. Nucleic Acids Research 38: 3975-3983

Lathdavong L, Westberg J, Shao J, Dion CM, Kluczynski P, Lundqvist S, Axner O (2010) Faraday modulation spectrometry of nitric oxide addressing its electronic X-2 Pi - A(2)Sigma(+) band: I. theory. Applied Optics 49: 5597-5613

Lundmark R, Carlsson SR (2010) Driving membrane curvature in clathrin-dependent and clathrin-independent endocytosis. Semin Cell Dev Biol 21: 363-370

Lundqvist J, Larsson C, Nelson M, Andersson M, Bergström S, Persson C (2010) Concomitant infection decreases the malaria burden but escalates relapsing fever borreliosis. Infect Immun 78: 1924-1930

Magalhaes A, Gomes J, Ismail MN, Haslam SM, Mendes N, Osorio H, David L, Lependu J, Haas R, Dell A, Borén T, Reis CA (2010) Fut2-Null Mice Display An Altered Gastric Mucosa Glycosylation Profile and Modified Helicobacter pylori Adhesion. Glycobiology 20: 1460-1461

Martin S, Terry H, Bridgeman A, Harris C, Blair E, Arnberg N, Hanke T, Easton A, Burgert HG (2010) Potential of a New Subgroup D Adenovirus Vector for Vaccination. Human Gene Therapy 21: 497-498

McElhinny SAN, Kumar D, Clark AB, Watt DL, Watts BE, Lundström EB, Johansson E, Chabes A, Kunkel TA (2010) Genome instability due to ribonucleotide incorporation into DNA. Nat Chem Biol 6: 774-781

McElhinny SAN, Watts BE, Kumar D, Watt DL, Lundström EB, Burgers PMJ, Johansson E, Chabes A, Kunkel TA (2010) Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases. Proceedings of the National Academy of Sciences of the United States of America 107: 4949-4954

Müller CM, Schneider G, Dobrindt U, Emody L, Hacker J, Uhlin BE (2010) Differential effects and interactions of endogenous and horizontally acquired H-NS-like proteins in pathogenic Escherichia coli. Molecular Microbiology 75: 280-293

Olofsson A, Vallstrom A, Petzold K, Tegtmeyer N, Schleucher J, Carlsson S, Haas R, Backert S, Wai SN, Gröbner G, Arnqvist A (2010) Biochemical and functional characterization of Helicobacter pylori vesicles. Molecular Microbiology 77: 1539-1555

Park HS, Östberg Y, Johansson J, Wagner EGH, Uhlin BE (2010) Novel role for a bacterial nucleoid protein in translation of mRNAs with suboptimal ribosome-binding sites. Genes & Development 24: 1345-1350

Ramstedt M, Franklyn P (2010) Difficulties in determining valence for Ag-0 nanoparticles using XPS - characterization of nanoparticles inside poly (3-sulphopropyl methacrylate) brushes. Surf Interface Anal 42: 855-858

Romby P, Charpentier E (2010) An overview of RNAs with regulatory functions in Gram-positive bacteria. Cell Mol Life Sci 67: 217-237

Rosenbaum E, Sellstedt M, Almqvist F, Johansson LBA (2010) Unusual Light Spectroscopic Properties of a 2-Pyridone-Based Multi-Ring-Fused Fluorescent Scaffold. J Fluoresc 20: 1249-1253

Schmidt FM, Ma W, Foltynowicz A, Axner O (2010) Highly sensitive dispersion spectroscopy by probing the free spectral range of an optical cavity using dual-frequency modulation. Applied Physics B-Lasers and Optics 101: 497-509

Sellstedt M, Nyberg A, Rosenbaum E, Engström P, Wickström M, Gullbo J, Bergström S, Johansson LBA, Almqvist F (2010) Synthesis and Characterization of a Multi Ring-Fused 2-Pyridone-Based Fluorescent Scaffold. European Journal of Organic Chemistry: 6171-6178

Shao J, Lathdavong L, Westberg J, Kluczynski P, Lundqvist S, Axner O (2010) Faraday modulation spectrometry of nitric oxide addressing its electronic X-2 Pi - A(2)Sigma(+) band: II. experiment. Applied Optics 49: 5614-5625

Shen H, Harris G, Chen W, Sjöstedt A, Ryden P, Conlan W (2010) Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy. PLoS One 5: e13349

Song TY, Sabharwal D, Wai SN (2010) VrrA Mediates Hfq-Dependent Regulation of OmpT Synthesis in Vibrio cholerae. Journal of Molecular Biology 400: 682-688

Spjut S, Qian WX, Elofsson M (2010) Synthesis and Application of a 2- (4-Fluorophenyl)-sulfonyl ethoxy Carbonyl (Fsec) Protected Glycosyl Donor in Carbohydrate Chemistry. Molecules 15: 5708-5720

Styer CM, Hansen LM, Cooke CL, Gundersen AM, Choi SS, Berg DE, Benghezal M, Marshall BJ, Peek RM, Borén T, Solnick JV (2010) Expression of the BabA Adhesin during Experimental Infection with Helicobacter pylori. Infection and Immunity 78: 1593-1600

Syngkon A, Elluri S, Koley H, Rompikuntal PK, Saha DR, Chakrabarti MK, Bhadra RK, Wai SN, Pal A (2010) Studies on a novel serine protease of a DeltahapADeltaprtV Vibrio cholerae O1 strain and its role in hemorrhagic response in the rabbit ileal loop model. PLoS One 5(9): e13122.

Toledo A, Anda P, Escudero R, Larsson C, Bergström S, Benach JL (2010) Phylogenetic Analysis of a Virulent Borrelia Species Isolated from Patients with Relapsing Fever. Journal of Clinical Microbiology 48: 2484-2489

Tsaponina O, Chabes A (2010) HMG-box protein lxr1 is required for DNA-damage-induced expression of ribonucleotide reductase Rnr1. Febs Journal 277: 167-168

Weber B, Chen C, Milton DL (2010) Colonization of fish skin is vital for Vibrio anguillarum to cause disease. Environ Microbiol Rep 2: 133-139

Westberg J, Lathdavong L, Dion CM, Shao J, Kluczynski P, Lundqvist S, Axner O (2010) Quantitative description of Faraday modulation spectrometry in terms of the integrated linestrength and 1st Fourier coefficients of the modulated lineshape function. Journal of Quantitative Spectroscopy & Radiative Transfer 111: 2415-2433

Wilhelmsson P, Fryland L, Börjesson S, Nordgren J, Bergström S, Ernerudh J, Forsberg P, Lindgren PE (2010) Prevalence and diversity of Borrelia species in ticks that have bitten humans in Sweden. J Clin Microbiol 48: 4169-4176

Wolf-Watz H (2010) Yersinia blocks innate immunity via the TypeIII secretion system; a possible drug target for novel therapy? Febs Journal 277: 34-35

Yasmin L, Veesenmeyer JL, Diaz MH, Francis MS, Ottmann C, Palmer RH, Hauser AR, Hallberg B (2010) Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins. Biochemical Journal 427: 217-224