Publications 2013

Bengtsson, C.; Nelander, H; Almqvist, F.#, Asymmetric Synthesis of 2,4,5-Trisubstituted 2-Thiazolines. Chemistry-A European Journal, 2013, doi.org/10.1002/chem.201301120.

Gupta, A., Sharma, S., Reichenbach, P., Marjavaara, L., Nilsson, A.K., Lingner, J., Chabes, A., Rothstein, R., & Chang, M. (Epub 2013 Jan 18) Telomere length homeostasis responds to changes in intracellular dNTP pools. Genetics (in press).

Hussain, M.; Sainte-Luce Banchelin, T.; Andersson, H.; Olsson, R.*; Almqvist, F.*, Enantioselective synthesis of substituted piperidines by addition of Grignard reagents to pyridine-N-oxides. Org. Lett., 2013, 15 (1), 54-57. (Highlighted in Synfacts, 2013, 9 (4), 0429.) (*)

Horvath, M.; Sellstedt, M.; Weise, C.; Nordvall, L-M.; Prasad, G. K.; Olofsson, A.; Larsson, G.; Almqvist, F.*; Wittung-Stafshede, P.*, Modulation of -synuclein fibrillization by ring-fused 2-pyridones: Templation and inhibition involve oligomers with different structure. Arch. Biochem. Biophys. 2013, 532, 84-90.

Williams, J.S., Smith, D.J., Marjavaara, L., Lujan, S.A., Chabes, A., & Kunkel, T.A. (Epub 2013 Jan 29) Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA. Mol Cell (in press).

Hoch, N.C., Chen, E.S., Buckland, R., Wang, S.C., Fazio, A., Hammet, A., Pellicioli, A., Chabes, A., Tsai, M.D., & Heierhorst, J. (Epub 2013 Jun 10). Molecular basis of the essential s phase function of the rad53 checkpoint kinase. Mol Cell Biol. 33, 3202-3213.

Tsaponina, O., & Chabes, A. Pre-activation of the genome integrity checkpoint increases DNA damage tolerance. Accepted to Nucleic Acids Res. on the 20-Aug-2013.

H. Antti, A. Fahlgren, E. Nasstrom, K. Kouremenos, J. Sunden-Cullberg, Y. Guo, T.Moritz, H. Wolf-Watz, A. Johansson and M. Fallman, Metabolic profiling for detection of staphylococcus aureus infection and antibiotic resistance, PLoS One 8 (2013), no. 2, e56971.

Bystrom, J., Thomson S.J., Johansson, J., Edin, M.L., Zeldin, D.C., Gilroy, D.W., Smith, A.M. and Bishop-Bailey, D. 2013. Inducible CYP2J2 and its product 11,12-EET promotes bacterial phagocytosis: a role for CYP2J2 deficiency in the pathogenesis of Crohn's Disease? PLoS One, Accepted for publication.

Mellin, J. R., Tiensuu, T., Bécavina, C., Gouin, E., Johansson, J.,# and Cossart, P. # A riboswitch-regulated antisense RNA in Listeria monocytogenes. Proc. Natl. Acad. Sci. USA, 110: 13132-13137. 2013.

Tiensuu. T., Andersson, C., Rydén, P. and Johansson J#. 2013. Cycles of light and dark co-ordinate reversible colony differentiation in Listeria monocytogenes. Mol Microbiol. 87:909-924. 2013.

Chylinski K, Le Rhun A and Charpentier E. 2013. The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems. RNA Biol. 10(5) (Ahead of print).

Edwin, A., Rompikuntal, P., Björn, E., Stier, G., Wai, S.N. & Sauer-Eriksson A.E. Calcium binding by the PKD1 domain regulates interdomain flexibility in Vibrio cholerae metalloprotease PrtV (2013) FEBS Open Bio, accepted

A. E. G. Lindgren, T. Karlberg, A, -G. Thorsell, M. Hesse, S. Spjut, T. Ekblad, C. D. Andersson, A. Pinto, J. Weigelt, M. O. Hottiger, A. Linusson, M. Elofsson, H. Schüler. A PARP inhibitor with selectivity toward ADP- ribosyltransferase ARTD3/PARP3. ACS Chemical Biology, accepted.

Bröms JE, Ishikawa T, Wai SN, Sjöstedt A (2013). A functional VipA-VipB interaction is required for the type VI secretion system activity of Vibrio cholerae O1 strain A1552. BMC Microbiol. 3;13(1):96.

Russell AB, LeRoux M, Hathazi K, Agnello DM, Ishikawa T, Wiggins PA, Wai SN, Mougous JD. (2013) Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors. Nature 496(7446):508-12

Thay B, Wai SN, and Oscarsson J. (2013) Staphylococcus aureus a-Toxin-Dependent Induction of Host Cell Death by Membrane-Derived Vesicles. PloS ONE, 2013;8(1):e54661

Thorslund SE, Ermert D, Fahlgren A, Erttmann SF, Nilsson K, Hosseinzadeh A, Urban CF, Fällman M. (2013) Role of YopK in Yersinia pseudotuberculosis Resistance Against Polymorphonuclear Leukocyte Defense Infect Immun 81:11-22.

Lindgren, M., Eneslätt, K., Bröms, J.E., and Sjöstedt, A. (2013). Importance of PdpC, IglC, IglI, and IglG for modulation of a host cell death pathway induced by Francisella tularensis. Infect Immun. 81:2076-84.

Lindgren, M., Meyer L, Golovliov, I., Bröms JE, Sjöstedt A. (2013) The Francisella tularensis LVS pdpC mutant exhibits a unique phenotype during intracellular infection. BMC Microbiol. 13:20.

Jeanette E. Bröms, Lena Meyer, Moa Lavander, Kun Sun, and Anders Sjöstedt. (2012). Unique substrates secreted by the type VI secretion system of Francisella tularensis during intramacrophage infection. PLoS One 7(11):e50473.

Ermert, D., Niemiec, M.J., Rohm, M., Glenthoj, A., Borregaard, N., Urban, C.F. (2013) Candida albicans escapes from mouse neutrophils. J Leukoc Biol 94, 223-36.

Seper, A., Hosseinzadeh, A., Gorkiewicz, G., Lichtenegger, S., Roier, S., Leitner, D.R., Röhm, M., Grutsch, A., Reidl, J., Urban, C.F., Schild, S. (2013) Vibrio cholerae evades neutrophil extracellular traps by the activity of two extracellular nucleases. PLoS Pathogens accepted.

Duperthuy M, Sjöström A, Sabharwal D, Damghani F, Uhlin BE, Wai SN. 2013. Role of the Vibrio cholerae matrix protein Bap1 in cross-resistance to antimicrobial peptides. PLoS pathogens (in press)
Hogg, M., Osterman, P., Bylund, G., Ganai, R.A., Lundström, E.- B. Lundström, Sauer-Eriksson, A. E. and Johansson E. Structural basis for processive DNA synthesis by yeast DNA polymerase epsilon. NSMB in press

Fuhrmann J, Mierzwa B, Trentini DB, Spiess S, Lehner A, Charpentier E and Clausen T. 2013. Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria. Cell Rep. 3(6):1832-1839.

Chylinski K, Le Rhun A and Charpentier E. 2013. The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems. RNA Biol. 10(5) (Ahead of print).

Fuhrmann J, Mierzwa B, Trentini DB, Spiess S, Lehner A, Charpentier E and Clausen T. 2013. Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria. Cell Rep. 3(6):1832-1839.

Chylinski K, Le Rhun A and Charpentier E. 2013. The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems. RNA Biol. 10(5) (Ahead of print).

Charpentier E, and Doudna JA. 2013. Biotechnology: Rewriting a genome. Nature (News and Views) 495(7439): 50-51.

Fineran P., Lundgren M. and Charpentier E. Planned 2013. Preface. "Methods in Molecular Biology", Volume "CRISPR", Springer (Guest Editor).

Fonfara I, Le Rhun A, Chylinski K, Makarova KS, Lécrivain AL, Bzdrenga J, Koonin EV and Charpentier E. 2013. Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems. Nucleic Acids Res. In press.

Amer AA, Costa TR, Farag SI, Avican U, Forsberg A, Francis MS. Genetically Engineered Frameshifted YopN-TyeA Chimeras Influence Type III Secretion System Function in Yersinia pseudotuberculosis. PLoS One. 2013 Oct 3;8(10):e77767. doi: 10.1371/journal.pone.0077767. PubMed PMID: 24098594; PubMed Central PMCID:PMC3789692.

Francis MS. The pathogenic Yersiniae--advances in the understanding of physiology and virulence. Front Cell Infect Microbiol. 2013 Sep 12;3:51. doi: 10.3389/fcimb.2013.00051. PubMed PMID: 24062993; PubMed Central PMCID: PMC3770916.

Obi IR, Francis MS. Demarcating SurA activities required for outer membrane targeting of Yersinia pseudotuberculosis adhesins. Infect Immun. 2013 Jul;81(7):2296-308. doi: 10.1128/IAI.01208-12. Epub 2013 Apr 15. PubMed PMID: 23589578; PubMed Central PMCID: PMC3697617.

Costa TR, Amer AA, Farag SI, Wolf-Watz H, Fällman M, Fahlgren A, Edgren T, Francis MS. Type III secretion translocon assemblies that attenuate Yersinia virulence. Cell Microbiol. 2013 Jul;15(7):1088-110. doi: 10.1111/cmi.12100. Epub 2013 Jan 21. PubMed PMID: 23279117.

Engström P, Nguyen BD, Normark J, Nilsson I, Bastidas RJ, Gylfe A, Elofsson M, Fields KA, Valdivia RH, Wolf-Watz H, Bergström S. Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity. J Bacteriol. 2013 Sep;195(18):4221-30. doi: 10.1128/JB.00506-13. Epub 2013 Jul 12.

Igor Golovliov, Susan Twine, Hua Shen, Anders Sjöstedt, Wayne Conlan. (2013) A ΔclpB mutant of Francisella tularensis subspecies holarctica strain, FSC200, is a more effective live vaccine than F. tularensis LVS in a mouse respiratory challenge model of tularemia. PLoS One. In the press.

Jeanette E. Bröms, Takahiko Ishikawa, Sun N. Wai, and Anders Sjöstedt. (2013). The role of the putative trimeric VipA/B, ClpV complex in Hcp secretion of Vibrio cholerae. BMC Microbiol. 13:96.

Lindgren, M., Eneslätt, K., Bröms, J.E., and Sjöstedt, A. (2013). Importance of PdpC, IglC, IglI, and IglG for modulation of a host cell death pathway induced by Francisella tularensis. Infect Immun. 81:2076-84.

Yang F, Korban SS, Pusey PL, Elofsson M, Sundin GW, Zhao Y. Small-molecule inhibitors suppress the expression of both type III secretion and amylovoran biosynthesis genes in Erwinia amylovora. Mol Plant Pathol. 2013 Jul 19. doi: 10.1111/mpp.12064. [Epub ahead of print] PMID: 23915008 [PubMed - as supplied by publisher] Related citations Select item 23852872

Engström P, Nguyen BD, Normark J, Nilsson I, Bastidas RJ, Gylfe A, Elofsson M, Fields KA, Valdivia RH, Wolf-Watz H, Bergström S. Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity. J Bacteriol. 2013 Sep;195(18):4221-30. doi: 10.1128/JB.00506-13. Epub 2013 Jul 12.PMID: 23852872 [PubMed - in process] Free PMC Article Related citations Select item 23742272

Lindgren AE, Karlberg T, Thorsell AG, Hesse M, Spjut S, Ekblad T, Andersson CD, Pinto AF, Weigelt J, Hottiger MO, Linusson A, Elofsson M, Schüler H. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem Biol. 2013 Aug 16;8(8):1698-703. doi: 10.1021/cb4002014. Epub 2013 Jun 25. PMID: 23742272 [PubMed - in process] Related citations

C. E. Zetterström, J. Hasselgren, O. Salin, R. A. Davis, R. J. Quinn, C. Sundin, M. Elofsson The resveratrol tetramer (-)-hopeaphenol inhibits type III secretion in the gram-negative pathogens Yersinia pseudotuberculosis and Pseudomonas aeruginosa. PLOS ONE, accepted.

Ermert, D., Niemiec, M.J., Rohm, M., Glenthoj, A., Borregaard, N., Urban, C.F. (2013) Candida albicans escapes from mouse neutrophils. J Leukoc Biol 94, 223-36.

Seper, A., Hosseinzadeh, A., Gorkiewicz, G., Lichtenegger, S., Roier, S., Leitner, D.R., Rohm, M., Grutsch, A., Reidl, J., Urban, C.F., Schild, S. (2013) Vibrio cholerae evades neutrophil extracellular traps by the activity of two extracellular nucleases. PLoS Pathog 9, e1003614.

Hosseinzadeh, A., Urban, C.F. (2013) Novel Insight into Neutrophil Immune Responses by Dry Mass Determination of Candida albicans Morphotypes. PLoS One 8, e77993.

Almyroudis, N.G., Grimm, M.J., Davidson, B.A., Rohm, M., Urban, C.F., Segal, B.H. (2013) NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury. Front Immunol 4, 45.

Bárcena-Uribarri I, Thein M, Maeier E, Bonde M, Bergström S and Benz R. Use of Nonelectrolytes Reveals the Channel Size and Oligomeric Constitution of the Borrelia burgdorferi P66 Porin 2013, PLoSOne (11): e78272 DOI: 10.1371/journal.pone.0078272

Mellin, J. R., Tiensuu, T., Bécavina, C., Gouin, E., Johansson, J.,# and Cossart, P. # A riboswitch-regulated antisense RNA in Listeria monocytogenes. Proc. Natl. Acad. Sci. USA, 110: 13132-13137. 2013. #Corresponding Authors *

Tiensuu. T., Andersson, C., Rydén, P. and Johansson J#. 2013. Cycles of light and dark co-ordinate reversible colony differentiation in Listeria monocytogenes. Mol Microbiol. 87:909-924. 2013. #Corresponding Author