Publications 2009

Aldick, T., Bielaszewska, M., Uhlin, B., Humpf, H., Wai, S., and Karch, H. (2009). Vesicular stabilization and activity augmentation of enterohaemorrhagic Escherichia coli haemolysin. Mol Microbiol 71, 1496-1508.


Andersson, H., Gustafsson, M., Boström, D., Olsson, R., and Almqvist, F. (2009). The regio- and stereoselective synthesis of trans-2,3-dihydropyridine N-oxides and piperidines. Angew Chem Int Ed Engl 48, 3288-3291
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Arnberg, N. (2009). Adenovirus receptors: implications for tropism, treatment and targeting. Rev Med Virol 19, 165-178.

Bernardo, L., Johansson, L., Skärfstad, E., and Shingler, V. (2009). sigma54-promoter discrimination and regulation by ppGpp and DksA. J Biol Chem 284, 828-838.

Björnfot, A., Lavander, M., Forsberg, A., and Wolf-Watz, H. (2009). Autoproteolysis of YscU of Yersinia pseudotuberculosis is important for regulation of expression and secretion of Yop proteins. J Bacteriol 191, 4259-4267.

Björnham, O., and Axner, O. (2009). Multipili attachment of bacteria with helixlike pili exposed to stress. J Chem Phys 130, 235102.

Björnham, O., Bugaytsova, J., Borén, T., and Schedin, S. (2009). Dynamic force spectroscopy of the Helicobacter pylori BabA-Lewis b binding. Biophys Chem 143, 102-105.

Brännström, K., Sellin, M., Holmfeldt, P., Brattsand, M., and Gullberg, M. (2009). The Schistosoma mansoni protein Sm16/SmSLP/SmSPO-1 assembles into a nine-subunit oligomer with potential To inhibit Toll-like receptor signaling. Infect Immun 77, 1144-1154.

Bröms, J., Lavander, M., and Sjöstedt, A. (2009). A conserved alpha-helix essential for a type VI secretion-like system of Francisella tularensis. J Bacteriol 191, 2431-2446.

Castelain, M., Koutris, E., Andersson, M., Wiklund, K., Björnham, O., Schedin, S., and Axner, O. (2009). Characterization of the biomechanical properties of T4 pili expressed by Streptococcus pneumoniae--a comparison between helix-like and open coil-like pili. Chemphyschem 10, 1533-1540.

Castelain, M., Sjöström, A., Fällman, E., Uhlin, B., and Andersson, M. (2009). Unfolding and refolding properties of S pili on extraintestinal pathogenic Escherichia coli. Eur Biophys J.

Cegelski, L., Pinkner, J. S., Hammer, N. D., Hung, C. S., Chorell, E., Åberg, V., Garofalo, C. K., Walker, J. N., Seed, P. C., Almqvist, F., Chapman, M. R. Hultgren, S. J., (2009) Small molecule inhibitors target E. coli amyloid biogenesis and biofilm formation, Nature Chemical Biology, 5, No 12, 913- 919.

Comstedt, P., Asokliene, L., Eliasson, I., Olsen, B., Wallensten, A., Bunikis, J., and Bergström, S. (2009). Complex population structure of Lyme borreliosis group spirochete Borrelia garinii in subarctic Eurasia. PLoS One 4, e5841.

Engström, P., Bailey, L., Onskog, T., Bergström, S., and Johansson, J. (2009). A comparative study of RNA and DNA as internal gene expression controls early in the developmental cycle of Chlamydia pneumoniae. FEMS Immunol Med Microbiol.

Fahlgren, A., Westermark, L., Akopyan, K., and Fällman, M. (2009). Cell type-specific effects of Yersinia pseudotuberculosis virulence effectors. Cell Microbiol 11, 1750-1767.

Fuhrmann, J., Schmidt, A., Spiess, S., Lehner, A., Turgay, K., Mechtler, K., Charpentier, E., and Clausen, T. (2009). McsB is a protein arginine kinase that phosphorylates and inhibits the Heat-shock regulator CtsR. Science. 324, 1323-7.

Guo, B., Teneberg, S., Mınch, R., Terunuma, D., Hatano, K., Matsuoka, K., Angström, J., Borén, T., and Bergström, S. (2009). Relapsing fever Borrelia binds to neolacto glycans and mediates rosetting of human erythrocytes. Proc Natl Acad Sci U S A 106, 19280-19285.

Holmfeldt, P., Sellin, M., and Gullberg, M. (2009). Predominant regulators of tubulin monomer-polymer partitioning and their implication for cell polarization. Cell Mol Life Sci 66, 3263-3276.

Isaksson, E., Aili, M., Fahlgren, A., Carlsson, S., Rosqvist, R., and Wolf-Watz, H. (2009). The membrane localization domain is required for intracellular localization and autoregulation of YopE in Yersinia pseudotuberculosis. Infect Immun 77, 4740-4749.

Ishikawa, T., Rompikuntal, P., Lindmark, B., Milton, D., and Wai, S. (2009). Quorum sensing regulation of the two hcp alleles in Vibrio cholerae O1 strains. PLoS One 4, e6734.

Johansson, J. (2009). RNA thermosensors in bacterial pathogens. Contrib Microbiol 16, 150-160.

Johansson, S., Nilsson, E., Qian, W., Guilligay, D., Crepin, T., Cusack, S., Arnberg, N., and Elofsson, M. (2009). Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis. J Med Chem 52, 3666-3678.

Jonsson, M., Lenman, A., Frängsmyr, L., Nyberg, C., Abdullahi, M., and Arnberg, N. (2009). Coagulation factors IX and X enhance binding and infection of adenovirus types 5 and 31 in human epithelial cells. J Virol 83, 3816-3825.

Kadzhaev, K., Zingmark, C., Golovliov, I., Bolanowski, M., Shen, H., Conlan, W., and Sjöstedt, A. (2009). Identification of genes contributing to the virulence of Francisella tularensis SCHU S4 in a mouse intradermal infection model. PLoS One 4, e5463.

Larsson, C., Andersson, M., and Bergström, S. (2009). Current issues in relapsing fever. Curr Opin Infect Dis 22, 443-449.

Larsson, C., Lundqvist, J., van Rooijen, N., and Bergström, S. (2009). A novel animal model of Borrelia recurrentis louse-borne relapsing fever borreliosis using immunodeficient mice. PLoS Negl Trop Dis 3, e522.

Lindgren, H., Honn, M., Golovlev, I., Kadzhaev, K., Conlan, W., and Sjöstedt, A. (2009). The 58-kilodalton major virulence factor of Francisella tularensis is required for efficient utilization of iron. Infect Immun 77, 4429-4436.

Lindmark, B., Rompikuntal, P., Vaitkevicius, K., Song, T., Mizunoe, Y., Uhlin, B., Guerry, P., and Wai, S. (2009). Outer membrane vesicle-mediated release of cytolethal distending toxin (CDT) from Campylobacter jejuni. BMC Microbiol 9, 220.

Liu J., Obi, I. and Francis M.S. 2009. Phosphorylated CpxR negatively regulates virulence gene expression in Yersinia pseudotuberculosis. J. Biol. Chem. (JBC/2009/081158)

Loh, E., Dussurget, O., Gripenland, J., Vaitkevicius, K., Tiensuu, T., Mandin, P., Repoila, F., Buchrieser, C., Cossart, P., and Johansson, J. (2009). A trans-acting riboswitch controls expression of the virulence regulator PrfA in Listeria monocytogenes. Cell 139, 770-779.

Lundberg, E., Olofsson, A., Westermark, G., and Sauer-Eriksson, A. (2009). Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein. FEBS J 276, 1999-2011.

Meibom, K., Forslund, A., Kuoppa, K., Alkhuder, K., Dubail, I., Dupuis, M., Forsberg, A., and Charbit, A. (2009). Hfq, a novel pleiotropic regulator of virulence-associated genes in Francisella tularensis. Infect Immun 77, 1866-1880.

Müller, C., Aberg, A., Straseviçiene, J., Emody, L., Uhlin, B., and Balsalobre, C. (2009). Type 1 fimbriae, a colonization factor of uropathogenic Escherichia coli, are controlled by the metabolic sensor CRP-cAMP. PLoS Pathog 5, e1000303.

Najdenski, H., Golkocheva-Markova, E., Kussovski, V., Vesselinova, A., Garbom, S., and Wolf-Watz, H. (2009). Attenuation and preserved immunogenic potential of Yersinia pseudotuberculosis mutant strains evidenced in oral pig model. Zoonoses Public Health 56, 157-168.

Olofsson, A., Lindhagen-Persson, M., Vestling, M., Sauer-Eriksson, A., and Ohman, A. (2009). Quenched hydrogen/deuterium exchange NMR characterization of amyloid-beta peptide aggregates formed in the presence of Cu2+ or Zn2+. FEBS J 276, 4051-4060.

Olofsson, A., Sauer-Eriksson, A., and Ohman, A. (2009). Amyloid fibril dynamics revealed by combined hydrogen/deuterium exchange and nuclear magnetic resonance. Anal Biochem 385, 374-376.

Ou, G., Hedberg, M., Hörstedt, P., Baranov, V., Forsberg, G., Drobni, M., Sandström, O., Wai, S., Johansson, I., Hammarstöm, M., et al. (2009). Proximal small intestinal microbiota and identification of rod-shaped bacteria associated with childhood celiac disease. Am J Gastroenterol 104, 3058-3067.

Ou, G., Rompikuntal, P., Bitar, A., Lindmark, B., Vaitkevicius, K., Wai, S., and Hammarström, M. (2009). Vibrio cholerae cytolysin causes an inflammatory response in human intestinal epithelial cells that is modulated by the PrtV protease. PLoS One 4, e7806.

Petzold, K., Olofsson, A., Arnqvist, A., Gröbner, G., and Schleucher, J. (2009). Semiconstant-time P,H-COSY NMR: analysis of complex mixtures of phospholipids originating from Helicobacter pylori. J Am Chem Soc 131, 14150-14151.

Pudelko, M., Qian, W., and Elofsson, M. (2009). Synthesis and application of N-[1-(4-(4-fluorophenyl)-2,6-dioxocyclohexylidene)ethyl] (Fde)-protected amino acids for optimization of solid-phase peptide synthesis using gel-phase (19)F NMR spectroscopy. J Pept Sci 15, 264-271.

Rydén, P., Sjöstedt, A., and Johansson, A. (2009). Effects of climate change on tularaemia disease activity in Sweden. Glob Health Action 2.

Salomonsson, E., Forsberg, A., Roos, N., Holz, C., Maier, B., Koomey, M., and Winther-Larsen, H. (2009). Functional analyses of pilin-like proteins from Francisella tularensis: complementation of type IV pilus phenotypes in Neisseria gonorrhoeae. Microbiology 155, 2546-2559.

Salomonsson, E., Kuoppa, K., Forslund, A., Zingmark, C., Golovliov, I., Sjöstedt, A., Noppa, L., and Forsberg, A. (2009). Reintroduction of two deleted virulence loci restores full virulence to the live vaccine strain of Francisella tularensis. Infect Immun 77, 3424-3431.

Sellstedt, M., and Almqvist, F. (2009). A novel heterocyclic scaffold formed by ring expansion of a cyclic sulfone to sulfonamides. Org Lett 11, 5470-5472.

Sjöström, A., Balsalobre, C., Emödy, L., Westerlund-Wikström, B., Hacker, J., and Uhlin, B. (2009). The SfaXII protein from newborn meningitis E. coli is involved in regulation of motility and type 1 fimbriae expression. Microb Pathog 46, 243-252.

Sjöström, A., Sondén, B., Müller, C., Rydström, A., Dobrindt, U., Wai, S., and Uhlin, B. (2009). Analysis of the sfaX(II) locus in the Escherichia coli meningitis isolate IHE3034 reveals two novel regulatory genes within the promoter-distal region of the main S fimbrial operon. Microb Pathog 46, 150-158.

Song, T., and Wai, S. (2009). A novel sRNA that modulates virulence and environmental fitness of Vibrio cholerae. RNA Biol 6, 254-258.

Straskova, A., Pavkova, I., Link, M., Forslund, A.L., Kuoppa, K., Noppa, L., Kroca, M., Fucikova, A., Klimentova, J., Krocova, Z., et al. (2009). Proteome analysis of an attenuated Francisella tularensis dsbA mutant: identification of potential DsbA substrate proteins. J Proteome Res 8, 5336-5346.

Sundin, C., Elofsson, M., Wolf-Watz, H., and Rosell, S. (2009).[Virulence blocking antibiotics. Anti-bacterial agents with completely new action mechanisms. Lakartidningen 106, 2543-2545.

Talyzina, N., Ingvarsson, P., Zhu, J., Wai, S., and Andersson, A. (2009). Molecular diversification in the quorum-sensing system of Vibrio cholerae: Role of natural selection in the emergence of pandemic strains. Appl Environ Microbiol 75, 3808-3812.

Urban, C.F., Ermert, D., Abu Abed, U., Schmid, M., Nacken, W., Brinkmann, V., Jungblut, P.R., Zychlinsky, A. (2009). The Neutrophil extracellular trap proteome: Release of calprotectin is crucial in fungal infections. PLoS Pathog.Oct;5(10):e1000639. Epub 2009 Oct 30.

Valeru, S., Rompikuntal, P., Ishikawa, T., Vaitkevicius, K., Sjöling, A., Dolganov, N., Zhu, J., Schoolnik, G., and Wai, S. (2009). Role of melanin pigment in expression of Vibrio cholerae virulence factors. Infect Immun 77, 935-942.

Weber, B., Hasic, M., Chen, C., Wai, S., and Milton, D. (2009). Type VI secretion modulates quorum sensing and stress response in Vibrio anguillarum. Environ Microbiol 11, 3018-3028.