Nat. and Internat Seminar Series - Jerome Defardin: Heterchromatin replication timing is controlled by SMCHD1

Fri. 6 Mar, 2015 14:00 - 15:00
This event does not repeat

National and International Seminar Series 2015

Speaker:
Jérome Dejardin
Institute of Human Genetics, Montpellier, France

Title: Heterchromatin replication timing is controlled by SMCHD1

Host: Yuri Schwartz, Molbiol

Room: Betula, bldg 6M

Nat. and Internat Seminar Series - Rolf Ohlsson:Transcriptional coordination and the loss of it in cancer: New insights in the role of higher order chromatin structures

Fri. 20 Mar, 2015 14:00 - 15:00
This event does not repeat

National and International Seminar Series 2015

Speaker:

Rolf OhlssonKarolinska Institute, Stockholm

Title
Transcriptional coordination and the loss of it in cancer: New insights in the role of higher order chromatin structures

Room: Betula, bldg 6M, NUS Campus

Host: Jan Larsson, Molbiol

Seminar - Hans Spelbrink: Nucleoids And Nucleoid Associated Proteins

Mon. 23 Mar, 2015 9:00 - 10:00
This event does not repeat

Medical Biochemistry and Biophysics seminar:

Tuesday 24 March 15.15 KB3A9 Lilla hörsalen, KBC
Department of Medical Biochemistry and Biophysics Seminar Series

Speaker:
Hans Spelbrink
Radboud University Medical Centre, Nijmegen, The Netherlands.

Title: Nucleoids and nucleoid associated proteins

Host: Sjoerd Wanrooij, Medical Biochemistry and Biophysics

Room: Lilla hörsalen, KB3A9

CANCELLED!- Kerstin Lindblad-Toh: Studying human disease and vertebrate evolution using comparative genetics and genomics

Mon. 23 Mar, 2015 14:15 - 15:15
This event does not repeat

Department of Medical Biochemistry and Biophysics

Extra Seminar

Speaker:

Kerstin Lindblad-Toh
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Science for Life Laboratory, Dept. of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

Title:
Studying human disease and vertebrate evolution using comparative genetics and genomics.

Room Lilla hörsalen, KB3A9, KBC
Host: Erik Johansson, Medchem

EXTRA Seminar - Cynthia M. Sharma: Regulatory RNAs in the pathogenic Epsilonproteobacteria, Helicobacter pylori and Campylobacter jejuni

Fri. 27 Mar, 2015 12:30 - 13:30
This event does not repeat

Speaker:
Dr. Cynthia M. Sharma
Research Centre for Infectious Diseases (ZINF)
University of Würzburg

Title:
"Regulatory RNAs in the pathogenic Epsilonproteobacteria, Helicobacter pylori and Campylobacter jejuni"


Place: Old Library, Dept of Molecular Biology (6L building)

Host: Sun Nyunt Wai, Dept. Molecular Biology

Nat. and Internat Seminar Series - Gunnar Nilsson: Mast cells – a hinge between innate and adaptive immunity

Fri. 27 Mar, 2015 14:00 - 15:00
This event does not repeat

National and International Serminar Series

 

Speaker:Gunnar Nilsson
Karolinska Institute, Stockholm

Title:
Mast cells – a hinge between innate and adaptive immunity

 

Place: Betula, NUS bldg 6M

Host Jose Petdro Lopez, Clinical Microbiology

Nat.and Internat. Seminar Series - Jesus de la Cruz: “Understanding ribosome biogenesis in eukaryotes

Fri. 10 Apr, 2015 13:00
This event does not repeat

Nat. an Internat Seminar Series

Speaker:
Jesus de la Cruz
Instituto de Biomedicina de Sevilla (IBIS)

Title:
Understanding ribosome biogenesis in eukaryotes

Place: Betula, NUS, bldg 6 M

Host: Tracy Nissan, molbiol

David A. Cisneros: Bacterial secretion and eukaryotic chromosome segregation: Large molecular assemblies at work

Mon. 1 Jun, 2015 11:00 - 12:00
This event does not repeat

MIMS_UCMR Extra seminar

Speaker:
David A. Cisneros
IMP - Research Institute of Molecular Pathology
Vienna, Austria

Title:
"Bacterial secretion and eukaryotic chromosome segregation: Large molecular assemblies at work"

Place: Major Groove, Department of Molecular Biology, Bldg L, NUS Campus
Host: Bernt Eric Uhlin

Abstract:

Work is defined as the operation of a force in producing movement or other physical change. My research has mainly focused in understanding how large protein complexes interact structurally and biochemically to produce this kind of work.
I will first discuss the correlation of molecular dynamic simulations with biochemical data, which I used to study the intermediate steps of assembly of the type II secretion system. This system is a large multi-protein complex that secretes folded proteins from the periplasm of Gram-negative bacteria to the extracellular space.
I will then discuss the cohesin complex. In eukaryotic cells, this complex forms a ring with a diameter of ~50 nm that is thought to topologically entrap the two sister chromatids after DNA replication. During metaphase, the cohesin complex ensures sister chromatid bi-orientation, which allows their equal segregation. I am using Cas9 genome engineering and super-resolution microscopy to study its assembly before and after replication.

UCMR/MIMS Mini-Symposium on Fungal Infections

Thu. 24 Sep, 2015 13:00 - 14:00
This event does not repeat

Speaker:

Christophe d'Enfert

Fungal Biology and Pathogenicity Unit - INRA USC2019
Department of Mycology,
Institut Pasteur 25, Paris,
France

 

Host: Constantin Urban

Room: Betula, bldg 6M, NUS

MIMS Extra Seminar - Franz Narberhaus: Unusual phospholipid biosynthesis pathways and RNA thermometers in bacteria

Mon. 14 Dec, 2015 14:00 - 15:00
This event does not repeat

MIMS Extra Seminar

Speaker:

Franz Narberhaus
Department of Microbial Biology
Ruhr-Universität Bochum
Germany

Title:
Unusual phospholipid biosynthesis pathways and RNA thermometers in bacteria


Room: Seminar Room Thymine, Department of Molecular Biology

Host: Emmanuelle Charpentier

Seminar - Oliver Billker: Regulating a complex life cycle — New molecular tools reveal mechanisms of malaria parasite transmission by mosquitoes

Tue. 16 Feb, 2016 14:15 - 15:15
This event does not repeat

MIMS- UCMR Seminar Medical Biochemistry and Biophysics Seminar

Speaker:
Oliver Billker
Wellcome Trust Sanger Institute, Cambridge, United Kingdom.

Title:
"Regulating a complex life cycle — New molecular tools reveal mechanisms of malaria parasite transmission by mosquitoes".

Host: Bernt Eric Uhlin

 

Place: Lilla hörsalen KB3A9, KBC

Seminar - Christian P.R. Hackenberger: New chemoselective reactions for the site-specific posttranslational modification and cellular delivery of functional proteins

Thu. 18 Feb, 2016 14:00 - 15:00
This event does not repeat

Department of Chemistry
Seminar
Speaker:
Professor Dr. Christian P. R. Hackenberger
Humboldt Universität zu Berlin
and
Leibniz-Institut für Molekulare Pharmakologie (FMP)


Title:
New chemoselective reactions for the site-specific posttranslational modification and cellular delivery of functional proteins

Place: Lilla hörsalen, KB3A9

Host: Christian Hedberg, Department of Chemistry


Abstract:
Our lab constantly aims to identify new bioorthogonal reactions for the synthesis and modification of functional peptides and proteins. We apply these highly selective organic reactions to study functional consequences of naturally occurring posttranslational protein modifications (PTMs) as well as to generate novel peptide- and protein-conjugates for pharmaceutical and medicinal applications.(1)

In the first part of this lecture, our recent efforts in the synthesis and analysis of naturally occurring labile PTMs including the synthesis of site-specifically phosphorylated Lys-peptides (pLys) using the Staudinger-phosphite reaction (2a) as well as phosphorylated Cys-peptides (pCys), (2b) will be presented.

In the second part of this presentation, I will focus on the cellular delivery of modified functional proteins. Thereby, we employ cyclic cell penetrating peptides (cCPPs) to transport a functional full length protein to the cytosol of living cells as recently demonstrated by the direct delivery of GFP-conjugates.(3) For protein modification we use a combined approach of intein expression, bioorthogonal reactions and recently developed enzymatic ligations, called Tub-tag labeling.4 This concept is finally applied to generate site-specifically labelled cell permeable nanobodies, i.e. small antigen binding proteins that remain active within the reductive milieu inside living cells, to interfere with intracellular targets.

References
(1.) D. Schumacher, C.P.R. Hackenberger, Curr. Opin. Chem. Biol. 2014, 22, 62-69.

(2.) a)J. Bertran-Vicente, R.A. Serwa, M. Schümann, P. Schmieder, E. Krause, C.P.R. Hackenberger, J. Am Chem. Soc. 2014, 136, 13622-13628;

(b) J. Bertran-Vicente, M. Penkert, O. Nieto, M. Schümann, P. Schmieder, E. Krause, C.P.R. Hackenberger, submitted.

(3.) N. Nischan, H.D. Herce, F. Natale, N. Bohlke, N. Budisa, M.C. Cardoso, C.P.R. Hackenberger, Angew. Chem. Int. Ed. 2015, 54, 1950-1953.

(4.) D. Schumacher, J. Helma, F.A. Mann, G. Pichler, F. Natale, E. Krause, M.C. Cardoso, C.P.R. Hackenberger, H. Leonhardt, Angew. Chem. Int. Ed. 2015, 54, 13787-13791.

Nat. and Internat. Seminar Series - Ivo Boneca: The peptidoglycan as a signalling molecule in the host

Fri. 4 Mar, 2016 14:15 - 15:15
This event does not repeat

National and International Seminar Series 2016

Seminar organised by MIMS

Speaker:

Ivo Boneca
Institute Pasteur, Paris, France

Title: The peptidoglycan as a signalling molecule in the host

Host: Felipe Cava

Place: Betula Bldg 6M

 

Prof. Boneca research aims at studying the role of bacterial peptidoglycan in host-microbe interactions. Using several bacterial models such as Helicobacter pylori, Neisseria meningitidis, Yersinia sp., and Listeria monocytogenes among others, his lab explores the dynamics of peptidoglycan sensing in the host cell during infection and the way pathogens are able to subvert/modulate the host response by modifying their peptidoglycan.

More information:
https://research.pasteur.fr/en/member/ivo-gomperts-boneca/

 

 

Nat and Internat Seminar - Mathias Hornef: Ontogeny of the intestinal host-microbial interaction

Fri. 11 Mar, 2016 14:00 - 15:00
This event does not repeat

National and International Seminar Series 2016

Speaker:

Mathias Hornef

Institute for Medical Microbiology, University Hospital, RWTH Aachen, Germany

Title: Ontogeny of the intestinal host-microbial interaction

Contact/host: Andrea Puhar, MolBiol and MIMS

Room: Betula, bldg 6M, NUS

 

More information:

http://www.ukaachen.de/en/clinics-institutes/institute-of-medical-microbiology/research/hornef-group.html

https://scholar.google.se/scholar?q=mathias+hornef&btnG=&hl=en&as_sdt=0%2C5

http://www.ncbi.nlm.nih.gov/pubmed/?term=mathias+hornef

Seminar- Andrea Puhar: Regulation of extracellular ATP-dependent inflammation in the gut

Tue. 15 Mar, 2016 14:15 - 15:15
This event does not repeat

Department of Medical Biochemistry and Biophysics Seminar Series

Speaker:
Andrea Puhar
Group leader MIMS

Title:
Regulation of extracellular ATP-dependent inflammation in the gut

Host: Anna Arnqvist
Place: Lilla hörsalen, KBC

Seminar - Tanel Tenson: Transfer routes of antibiotic resistance

Wed. 30 Mar, 2016 8:00 - 9:00
This event does not repeat

MIMS Seminar - Department of Molecular Biology

Speaker:
Tanel Tenson

Title:

Transfer routes of antibiotic resistance

Host: Vasili Hauryliuk, MIMS

Place: Major Groove, Bldg 6M, NUS


Antibiotics are some of the most influential innovations of medicine. However, the spread of resistance is a considerable threat that might take us back to the pre-antibiotic era. The problem is perceived as medical, although more than half of the amount of antibiotics produced is consumed in animal husbandry where resistance can also easily emerge.

The resistance can spread through food products, waste water systems, agricultural practices etc. Isolated transfer events have been characterised that outline these transfer routes, but we lack a quantitative knowledge about the extent and importance of the different segments.

Therefore, we have analyzed resistant bacteria critical for medicine in Southern Estonia, with emphasis on the settings around Tartu. The strains were collected from human samples, animal husbandry, ground waters, sewage and characterized by measuring antibiotic sensitivity patterns and whole genome sequencing. The results suggest transfer routes between the different segments under study.

 

 

Seminar: Antibiotic deliveryplatforms for targeting bone infections

Fri. 15 Apr, 2016 11:00 - 12:00
This event does not repeat

Speaker:
Anna Bettencourt
University of Lisbon, Protugal

Title:
"Antibiotic delivery platforms for targeting bone infections"

Room: Seminar room of the Department of Clinical Microbiology. BYGGNAD 6B, room 23
Department of Bacteriology /Department of Micobiology
The entrance is 50m left of bloodcenter, two stairs up and take left. Ring the bell at Microbiology

Host Madeleine Ramstedt

 

Information from Madeleine:

Madeleine Ramstedt has two guests here in Umeå next week that are from Lisbon in Portugal and that do research on how to prevent biofilm formation on medical devices using different approaches. I know them from a European network (www.ipromedai.net) working to find strategies for preventing infection of medical devices (including dental ones). They are here to see how we do our biofilm experiments in flow chambers.  
 
Here are links to their web pages:
 
http://imed.ulisboa.pt/cv/isabel-alexandra-caldeira-ribeiro/
 
http://imed.ulisboa.pt/cv/ana-francisca-de-campos-simao-bettencourt/
 
They will give a ~20 min presentation each on Friday 15th April starting at 13 in the afternoon and we will have some time also for questions and discussions. I expect the whole thing will take about an hour. We will be in the seminar room at Clinical microbiology. The titles for the talks will be:
 
"Antibiotic delivery platforms for targeting bone infections" (Ana F. Bettencourt)
 
"Sophorolipids: The Yeast Synthesised Glycolipids with Diverse Biological Activities" (Isabel A.C. Ribeiro)
 
I hope you would like to join us and listen to these guests.
If you have a colleague that you think may be interested please also forward this e-mail to them.
Everyone is very welcome to join the talks.

Seminar - Sophorolipids: The Yeast Synthesised Glycolipids with Diverse Biological Activities

Fri. 15 Apr, 2016 11:00
This event does not repeat

Speaker:
Isabel A.C. Ribeiro
University of Lisbon, Protugal

Title:
"Sophorolipids: The Yeast Synthesised Glycolipids with Diverse Biological Activities"

Room: Seminar room of the Department of Clinical Microbiology

Host Madeleine Ramstedt

 

Information from Madeleine:

Madeleine Ramstedt has two guests here in Umeå next week that are from Lisbon in Portugal and that do research on how to prevent biofilm formation on medical devices using different approaches. I know them from a European network (www.ipromedai.net) working to find strategies for preventing infection of medical devices (including dental ones). They are here to see how we do our biofilm experiments in flow chambers.  
 
Here are links to their web pages:
 
http://imed.ulisboa.pt/cv/isabel-alexandra-caldeira-ribeiro/
 
http://imed.ulisboa.pt/cv/ana-francisca-de-campos-simao-bettencourt/
 
They will give a ~20 min presentation each on Friday 15th April starting at 13 in the afternoon and we will have some time also for questions and discussions. I expect the whole thing will take about an hour. We will be in the seminar room at Clinical microbiology. The titles for the talks will be:
 
"Antibiotic delivery platforms for targeting bone infections" (Ana F. Bettencourt)
 
"Sophorolipids: The Yeast Synthesised Glycolipids with Diverse Biological Activities" (Isabel A.C. Ribeiro)
 
I hope you would like to join us and listen to these guests.
If you have a colleague that you think may be interested please also forward this e-mail to them.
Everyone is very welcome to join the talks.

Nat. and Internat. Seminar Series - J. Andrew Alspaugh: Hidden in plain sight: Avoidance of immunerecognition by pathogenic fungi

Fri. 22 Apr, 2016 13:00 - 14:00
This event does not repeat

National and International Seminar Series 2016

Speaker:

J. Andrew Alspaugh
Duke University, Department of Medicine, USA

Title:
Hidden in plain sight: Avoidance of immunerecognition by pathogenic fungi

Host Constantin Urban, Clinical Microbiology

Room: Betula Bldg 6M

Seminar - Jay C.D. Hinton: Understanding the choreography of Salmonella transcription with RNA-seq

Thu. 12 May, 2016 13:00 - 14:00
This event does not repeat

UCMR-MIMS Seminar

Speaker:
Jay C. D. Hinton
Institute of Integrative Biology, University of Liverpool, UK,

Title:
Understanding the choreography of Salmonella transcription with RNA-seq

Place: Thymine, Department of Molecular Biology, 2nd floor
http://www.umu.se/english/about-umu/campus-maps?id=480

Host: Bernt Eric Uhlin & Mikael Rhen

Abstract:

Bacterial transcriptional networks typically consist of hundreds of transcription factors and thousands of promoters. However, the true complexity of transcription in a bacterial pathogen remains to be established. We devised a suite of 22 different environmental conditions that reflect the pathogenic lifestyle of Salmonella enterica serovar Typhimurium strain 4/74 during infection of a host, and used RNA-seq to generate a compendium of Salmonella gene expression. Individual in vitro conditions stimulated characteristic transcriptional signatures, and the suite of 22 conditions induced expression of 86% of all S. typhimurium genes 1. Recently, we compared these in vitro conditions with the intra-macrophage gene expression profiles of S. typhimurium 2.  All the data can be accessed at http://tinyurl.com/SalComMac. We hope that this database of environmentally-controlled expression of every transcriptional feature of S. typhimurium will be a useful resource for the bacterial research community, and the results explain the environmental signals that stimulate S. typhimurium promoters during infection.

We found that the transcription of the majority of the 3825 S. typhimurium promoters is environmentally-responsive. Our global approach has identified 280 small RNAs in S. typhimurium; these sRNAs were analysed in the context of chromosome localisation and Hfq-association.

I will discuss the environmental conditions that stimulate expression of the Salmonella pathogenicity islands, will present a comprehensive expression landscape of sRNAs and discuss our approach for defining the relative strength of S. typhimurium promoters during macrophage infection.

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

References

1 Srikumar S, Kröger C, Hébrard M, Colgan A, Owen SV, Sivasankaran SK, Cameron ADS, Hokamp K, Hinton JCD: RNA-seq Brings New Insights to the Intra-Macrophage Transcriptome of Salmonella Typhimurium. PLOS Pathogens 2015, 11:e1005262.

2 Kröger C, Colgan A, Srikumar S, Handler K, Sivasankaran SK, Hammarlof DL, Canals R, Grissom JE, Conway T, Hokamp K, Hinton JC: An infection-relevant transcriptomic compendium for Salmonella enterica Serovar Typhimurium. Cell Host Microbe 2013, 14:683-695.

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