Seminar - Ceu Figueiredo: Clinical relevance of Helicobacter pylori genotyping

Tue. 27 Sep, 2011 13:15 - 14:15
This event does not repeat
Department of Medical Biochemistry and Biophysics Seminar Series fall 2011

Ceu Figueiredo, IPATIMUP and Medical Faculty of Porto, Portugal
"Clinical relevance of Helicobacter pylori genotyping"

Place: Lilla hörsalen, KB3A9, KBC


Seminar - Mary Cowman: Macromolecular crowding by Hyaluronan in the extracellular matrix

Thu. 29 Sep, 2011 13:15
This event does not repeat
Department of Biochemistry and Biophysics Seminar Series fall 2011

Mary Cowman
Polytechnic Institute of New York University, Brooklyn, U.S.A.

Title:
Macromolecular crowding by Hyaluronan in the extracellular matrix


Place: Lilla hörsalen, KB3A9, KBC

Hosts: Linus Malm/Göran Larsson

Seminar - Michael Williams: Rho-family GTPases in the Drosophila cellular immune reponse

Fri. 30 Sep, 2011 13:00 - 14:00
This event does not repeat
National and International Seminar Series Fall 2011:

Speaker:
Michael Williams
University of Aberdeen

Title:
Rho-family GTPases in the Drosophila cellular immune reponse


Place: Lecture Hall Betula, Bldg. 6 M, NUS

Seminar - Ola Blixt: Biomarker discovery platforms for glycomics

Tue. 4 Oct, 2011 13:15 - 14:15
This event does not repeat
Department of Medical Biochemistry and Biophysics
Speaker:
Ola Blixt

Faculty of Health Science
University of Copenhagen Denmark

Title:
Biomarker discovery platforms for glycomics

Place: Lilla hörsalen, KBC

Seminar - Ruth Palmer: Anaplastic Lymphoma Kinase: Signaling in flies and man

Fri. 7 Oct, 2011 13:00 - 14:00
This event does not repeat
The "National and International" Seminar Series, fall 2011

Speaker: Ruth Palmer, Department of Molecular Biology

Title: "Anaplastic Lymphoma Kinase: Signaling in flies and man"

Place: Lecture hall, Betula, Bldg. 6M


Seminar - Kerstin Lindblad-Toh: SciLifeLab Uppsala, prospect of future platform activities and possible collaborations

Thu. 10 Nov, 2011 10:00 - 11:00
This event does not repeat

Seminar för all interested people at KBC and UmU:

 

Speaker:

Kerstin Lindblad-Toh

Director, SciLifeLab Uppsala

Title:

SciLifeLab Uppsala, prospect of future platform activities and possible collaborations


Place: Stora hörsalen, KBC

Seminar - Stefan Marklund: Misfolded superoxide dismutase and amyotrophic lateral sclerosis

Fri. 11 Nov, 2011 14:00 - 15:00
This event does not repeat
National and International Seminar Series Fall 2011
UCMM, Molecular Biology, Medical Biosciences, Clinical Microbiology

Speaker:
Stefan Marklund
Medical Biosciences, Umeå University

Title:
Misfolded superoxide dismutase and amyotrophic lateral sclerosis

Place: Betula Salen Building 6M NUS

Seminar - Pål Falnes: Repair and modification of nucleic acids by oxygenases from the AlkB family

Fri. 18 Nov, 2011 14:00 - 15:00
This event does not repeat
The "National and International" Seminar Series, fall 2011

Speaker: Pål Falnes, University of Oslo

Title: "Repair and modification of nucleic acids by oxygenases from the AlkB family"

Place: Lecture hall, Betula, Bldg. 6M, University Hopsital Campus

Seminar - Victor Muñoz: Combining theory and experiment reveals surprinsingly simple universal rules in protein folding

Tue. 22 Nov, 2011 14:15 - 15:15
This event does not repeat
The Biochemistry and Biophysics Seminar Series fall 2011

Speaker:
Victor Muñoz
Centro de Investigaciones Biológicas (CSIC), Madrid, Spain

Title: "Combining theory and experiment reveals Ssurprinsingly simple universal rules in protein folding"

Place: Lecture hall "Lilla hörsalen", KB3A9, KBC-building


Seminar - Stefan Björklund: The function of Arabidopsis thaliana Mediator in development, stress response and light signaling

Fri. 25 Nov, 2011 14:00 - 15:00
This event does not repeat
The "National and International" Seminar Series, Fall 2011

Speaker: Stefan Björklund, Medical Chemistry and Biophysics, Umeå University

Title: "The function of Arabidopsis thaliana Mediator in development, stress response and light signaling"

Place: Lecture hall, Betula, Bldg. 6M

KBC Lecture - Paul Helquist: From Simple Diene Chemistry to Therapies for Rare and Neglected Diseases

Wed. 14 Dec, 2011 12:00 - 13:00
This event does not repeat

KBC Lecture

Tage-Erlander Professor 2011

 

Paul Helquist

Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, Indiana

 

Title:

From Simple Diene Chemistry to Therapies for Rare and Neglected Diseases

 

Abstract

In a joint set of ventures, the Wiest and Helquist laboratories at Notre Dame, specializing in computational chemistry and drug synthesis, respectively, are supported by various funding mechanisms to reach out to investigators in other fields and at many institutions to form multi-disciplinary collaborative teams for the purpose of drug development. Most often, the external collaborators are at medical schools or other biomedical institutions and have major strengths in biological or clinical studies but do not have the chemistry expertise required for drug development. These collaborators have often identified a potential therapeutic protein target from cellular studies, or they have conducted compound screenings to identify initial hits. The next logical steps in these investigations are the design of protein binders or hit optimization, requiring the computational and synthetic chemistry input of our laboratories. The resulting compounds are provided back to the external collaborators and other appropriate parties for more extensive biological studies. Over the past few years, these collaborative ties have been established with many investigators at Cornell University Weill College of Medicine, Tufts University Medical School, Columbia University College of Physicians and Surgeons, Washington University School of Medicine, University of Texas Southwestern Medical Center, Broad Institute, Dana-Farber Cancer Institute, Purdue University, State University of New York at Albany, and Biological Sciences at Notre Dame.

This presentation will place emphasis on the history of our development of synthetic methods for dienes, especially with colleagues in Sweden, and the synthesis of target compounds as potential drugs for treating cancer and a rare, inherited disease.

 

Abstract with references for download here

More information about the Tage Erlander professor 2011

Seminar - Ingela Vikström: Resolving the stage-specific contribution of the anti-apoptotic proteins to humoral immunity

Wed. 21 Dec, 2011 13:00 - 14:00
This event does not repeat
Department of Clinical Microbiology

Extra Seminar
Title:
Resolving the stage-specific contribution of the anti-apoptotic proteins to humoral immunity

Ingela Vikström

Walter and Eliza Hall Institute
Melbourne, Australia

Place: Betula, University Hospital, building 6 M

-----------

Dr Ingela Vikström completed her PhD at the Dept. Med Biosciences, Umeå University in 2006. She then relocated to Melbourne Australia were she is currently a post doctoral fellow at the Walter and Eliza Hall Institute. Some of her recent publications include:

Vikstrom I, Tarlinton DM. B cell memory and the role of apoptosis in its formation. Mol Immunol. 2011 48:1301-6.
Vikstrom I, Carotta S, Lüthje K, Peperzak V, Jost PJ, Glaser S, Busslinger M, Bouillet P, Strasser A, Nutt SL, Tarlinton DM. Mcl-1 is essential for germinal center formation and B cell memory. Science. 2010 330:1095-9
Carrington EM, Vikstrom IB, Light A, Sutherland RM, Londrigan SL, Mason KD, Huang DC, Lew AM, Tarlinton DM. BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs. Proc Natl Acad Sci U S A. 2010 107:10967-71.



Seminar- Kurt Lackovic: High-Throughput Screening in an Academic Setting, a Bona Fide Path to Novel Therapeutics and Tool Molecules?

Thu. 22 Dec, 2011 13:00 - 14:00
This event does not repeat

Department of Clinical Microbiology
Extra Seminar
Title:
High-Throughput Screening in an Academic Setting, a Bona Fide Path to Novel Therapeutics and Tool Molecules?

Speaker:
Kurt Lackovic

Walter and Eliza Hall Institute Melbourne, Australia
Place: Betula, University Hospital, building 6 M


The Walter and Eliza Hall Institute of Medical Research was one of the first academic institutions in the world to establish a high-throughput screening facility. How this Facility operates, along with the format of projects, outcomes to date, examples of projects, and recent expansion to include high-content screening will be discussed.

 

Biography Paragraph:

Dr Kurt Lackovic completed his PhD in analytical chemistry in 2003. He then relocated to Sweden for his initial post doctoral placement, at the Department of Medical Biosciences, Umeå University, Sweden. Dr Lackovic returned to Melbourne in October 2006, immediately taking a position in the WEHI High-Throughput Chemical Screening (HTCS) Facility. In his current role, Dr Lackovic is responsible for managing collaborative research projects seeking lead-like molecules across a broad range of target classes and disease types, developing novel techniques, and reporting findings. In addition, he is responsible for the HTCS Facility's high-content imaging capabilities.


Recent publications include:
Croker et al. Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1. Proc Natl AcadSci U S A. 2011 108:13135-40.
Lackovic K, Parisot JP, Sleebs N, Baell JB, Debien L, Watson KG, Curtis JM,Handman E, Street IP, Kedzierski L. Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library. Antimicrob Agents Chemother. 2010 54:1712-9.

Seminar - Hindrik Mulder: Mitochondrial dysfunction in Type 2 Diabetes - a role for TFB1M

Thu. 26 Jan, 2012 14:30 - 15:30
This event does not repeat

Department of Chemistry announces:

Speaker:

Hindrik Mulder, Professor, MD
Unit of Molecular Metabolism Lund University
Diabetes Centre Department of Clinical Sciences

Title:
Mitochondrial dysfunction in Type 2 Diabetes - a role for TFB1M Host: Henrik Antti, Department of Chemistry

Place:
Biologihuset BiA 201 (Biology building)

Seminar - Urs Greber: Through the eyes of an adenovirus -- insights into host trafficking & beyond

Thu. 2 Feb, 2012 9:00 - 10:00
This event does not repeat
Clinical Microbiology / Virology
Extra Seminar
Speaker:
Urs Greber
Institute of Molecular Life Sciences, University of Zurich, Switzerland

Title:
Through the eyes of an adenovirus  -- insights into host trafficking & beyond

Place:
Lecture hall: Department of Infectious Diseases. Building 24, University Hospital
"Undervisningsnod K0"

Host: Ya-fang Mei, Department of Clinical Microbiology/Virology
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Seminar . Olli Salin: Approaches to discover antichlamydial compounds

Wed. 8 Feb, 2012 9:30 - 10:30
This event does not repeat

Department of Clinical Microbiology

Extra - Seminar

Speaker:

Olli Salin
Department of Biological Sciences Åbo Akademi University, Åbo, Finland

Title:
Approaches to discover antichlamydial compounds

 

Place: KB3A9 Lilla hörsalen KBC

Seminar - Anders Nordström: Quantitative and Kinetic Metabolomics to study mechanisms of drug resistance

Tue. 14 Feb, 2012 14:15
This event does not repeat
Medical Biochemistry and Biophysics Seminar Series, spring 2012

Anders Nordström, Department of Molecular Biology, Umeå University

Title: Quantitative and Kinetic Metabolomics to study mechanisms of drug resistance

Place: KB3A9, Lilla hörsalen, KBC

Host: Richard Lundmark

Seminar - Urs Greber: Through the eyes of an adenovirus -- insights into host trafficking & beyond

Fri. 2 Mar, 2012 9:00 - 10:00
This event does not repeat
Clinical Microbiology / Virology
Extra Seminar
Speaker:
Urs Greber
Institute of Molecular Life Sciences, University of Zurich, Switzerland

Title:
Through the eyes of an adenovirus  -- insights into host trafficking & beyond

Place:
Lecture hall: Department of Infectious Diseases. Building 24, University Hospital
"Undervisningsnod K0"

Host: Ya-fang Mei, Department of Clinical Microbiology/Virology
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Seminar - Myles Axton: Publishing your work in Nature journals

Wed. 2 May, 2012 12:00 - 13:00
This event does not repeat

Joint seminar UCMM - UCMR- MIMS - KBC

Speaker:

Myles Axton
Editor, Nature Genetics


Title:

Publishing your work in Nature journals

 

Host:

Helena Edlund

 

Place: Stora Hörsalen KB3B1, KBC

Video-Transfer-Seminar - John Overington: A data mining synthesis approach to the discovery of impersonalised, robust and safe therapies

Thu. 31 May, 2012 8:30 - 9:30
This event does not repeat

EMBL Partnership for Molecular Medicine (FIMM - MIMS - NCMM) joint Special Seminar at the Biomedicum in Helsinki.
Video transfer of the talk to Umeå and Oslo simultanously.

John Overington, EMBL Outstation - Hinxton, European Bioinformatics Institute, Cambridge, UK

"A data mining synthesis approach to the discovery of impersonalised, robust and safe therapies"

Abstract:
Adverse Drug Reactions, ADRs, are a major burden on healthcare systems, and arguably, if patients can be stratified, more novel therapies, tolerable in particular genotyped groups could be developed and launched. We have taken a data synthesis approach to explore ADRs and some of the underlying molecular recognition and pharmacokinetic concepts. We then derived a novel drug combination strategy which theoretically can greatly improve the safety of current therapies and also lead to more predictable and consistent patient population response.

pdf Summary for download

Place: Major Groove, Department of Molecular Biology, bldg 6L, University Hospital Area

Organizer in Sweden: Åke Forsberg
Host at FIMM in Finland: Heidi Virtanen
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