Note Room Change!
National and International Seminar Series Spring 2019
Speaker:
Lukas Kenner
Ludwig Boltzmann Inst for Cancer Research, Vienna, Austria
Title:
Genetics, transcriptional factors and models in preclinical studies of prostate cancer
Host: Jenny Persson
Room: Major Groove, Bldg 6L, NUS
Coffee/tea/cookies served 30 min before start
Please contact respective host for enquiries to meet with speaker
General questions regarding the seminar series; please contact This email address is being protected from spambots. You need JavaScript enabled to view it. or This email address is being protected from spambots. You need JavaScript enabled to view it.
NOTE ROOM CHANGE!
National and International Seminar Series Spring 2019
Speaker:
Derek Doherty
Trinity College, Dublin, Ireland
Title:
Targeting CD1d for cancer immunotherapy
Host: Johan Normark
Place: Major Groove, Dept of Molecular Biology, bldg 6L NUS
Coffee/tea/cookies served 30 min before start
Please contact respective host for enquiries to meet with speaker
General questions regarding the seminar series; please contact This email address is being protected from spambots. You need JavaScript enabled to view it. or This email address is being protected from spambots. You need JavaScript enabled to view it.
NOTE ROOM CHANGE!
National and International Seminar Series Spring 2019
Speaker:
Oriol Gallego
Pompeu Fabra, Barcelona, Spain
Title:
Towards the elusive mechanism of exocytosis: doing structural biology in living cells
Host: Franscesca Aguiló
Room: Major Groove, Dept of Molecular Biology, Bldg 6L, NUS
Coffee/tea/cookies served 30 min before start
Please contact respective host for enquiries to meet with speaker
General questions regarding the seminar series; please contact This email address is being protected from spambots. You need JavaScript enabled to view it. or This email address is being protected from spambots. You need JavaScript enabled to view it.
Department of Molecular Biology/MIMS
Extra Seminar
Speaker:
Himanshu Sharma
Indian Institute of Technology Guwahati, Assam, India
Title:
Ribosome assembly defects abrogate initiation factor mediated inspection of start codon
Host:
Jonas Barandun, MIMS group leader and SciLifeLab National Fellow, Department of Molecular Biology
Room: Thymine, Dept Molecular Biology, NUS, bldg 6K/L 2 stairs up
Abstract:
Faithful protein synthesis is ensured by extensive quality control checkpoints using components of the translational machinery. However, the implications of defective ribosome assembly on protein synthesis and the associated translation quality control mechanisms in bacteria remain grossly unaddressed. In this study, using E. coli as a model organism we show that premature ribosomes evade scrutiny of cognate start Codon by initiation factors during translation initiation. Resultantly the defective ribosomes make way into the translation cycle with severely compromised decoding and protein synthesis capabilities. The enfeebled binding of premature ribosomes to initiation factors also licenses the rapid conversion of the 30S (pre) initiation complex to 70S initiation complex. Overall, our work highlights that a mass balance deficit between premature ribosomes and initiation factors steers the entry of premature ribosomes into the translation cycle.
(Co-Author: B. Anand)
Department of Molecular Biology/MIMS
Extra Seminar
Magnus Ölander
Department of Pharmacy, Uppsala University
Title:
Proteomic and functional analysis of
in vitro systems for studies of drug disposition in the human small intestine and liver
Place: Thymine, Molecular Biology bldg. 6K/L (2 stairs up)
Host: Barbara Sixt, MIMS group leader, Dept of Molecular Biology