Medical Biochemistry and Biophysics Seminar Series, autumn 2012

Örjan Carlborg, Dept. of Clinical Sciences, Division of Computational Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden

"Understanding the genetic architecture of complex traits"

Place: lecture hall KB3A9, Lilla hörsalen, KBC

Host: Andrei Chabes

Abstract
Understanding how genes contribute to the phenotypic variability observed in populations is a major challenge in biology. A common approach to dissect the genetics of complex traits is to measure the genotype of individuals in a population at a large number of loci across the genome and then evaluate whether the phenotypic mean differs between the individuals that carry particular combinations of genetic variants, alleles, at either individual loci (i.e. detection of additive, dominance and epigenetic effects of loci) or at multiple loci (i.e. to detect genetic interactions or epistasis). I will here give a brief introduction to this topic and illustrate the insights that can be gained into the genetics of complex traits using these approaches by using examples from our research in domestic animals. An alternative, and promising, strategy to identify genes involved in gene-by-gene or gene-by-environment interactions is to search for loci that causes a difference in variance (a variance heterogeneity) between genotypes. This talk will be concluded by presenting some recent work to develop theory and tools for genome-wide mapping of individual variance-controlling loci. Empirical findings from studies of data in Arabidopsis thaliana and Saccharomyces cerevisiae will be used to illustrate the contribution of such loci to the genetic architecture of complex traits and the implications of the findings on our understanding of the genetic regulation of complex trait variation.

Thesis Defence

Pramod Kumar Rompikuntal, Department of Molecular Biology

"Outer membrane vesicle-mediated export of virulence factors from Gram-negative bacteria"

Place: Astrid Fagraeus-salen (A103), bldgs. 6A-L, NUS 

Opponent: Professor Ann-Beth Jonsson, University of Stockholm

Supervisor: Sun Nyunt Wai, Department of Molecular Biology

The "National and International" Seminar Series, autumn 2012

Dr. Denise Monack, Dept. of Microbiology and Immunology, Stanford University, California, USA

"Chronic Salmonella carriage is controlled by a host regulator of fatty acid metabolism PPARdelta"

Place: lecture hall Betula, bldg. 6M, NUS-area

Host: Anders Sjösted, Clinical Microbiology

Extra Seminar - MIMS/UCMR

Henrik Strahl, The Centre for Bacterial Cell Biology, Newcastle University, UK

"From a passive envelope to a highly organized scaffold: The active role of the cell membrane in bacterial growth and division."

Place: Major Groove, bldg. 6L, NUS-area

Host: Bernt Eric Uhlin, Department of Molecular Biology

The "National and International" Seminar Series, autumn 2012

Dr. Ting Xie, Stowers Institute for Medical Research, Kansas City, USA
"Stern Cells: Niche, Competition, Aging and Potential Application"

Host: Leif Carlsson, Umeå Center for Molecular Medicine

AND

Dr. Francois Guillemot, MRC National Institute for Medical Research, Mill Hill, London, UK
"Transcriptional controll of stern cell activity in the mouse brain"

Hosts: Tanushree Pandit/Lena Gunhaga, Umeå Center for Molecular Medicine

Place (both seminars): lecture hall Betula, bldg. 6M, NUS-area
NOTE TIME! The first seminar will start at 14.00!

Medical Biochemistry and Biophysics Seminar Series, autumn 2012

Oleg Antzutkin, Dept. of Civil, Environmental and Natural Resources Engineering, Sustainable Process Engineering, Luleå University of Technology, Luleå, Sweden

"Exploring hydrogen bonding in amyloid fibrils using 15N{17O} REAPDOR NMR"

Place: lecture hall KB3A9, Lilla hörsalen, KBC

Host: Anders Olofsson

BILS - Bioinformatics Infrastructure for Life Sciences
CLiC - Computational Life Science Cluster

Welcome to a presentation of BILS and Biosupport.se!
BILS (Bioinformatics Infrastructure for Life Sciences) is a distributed national research infrastructure providing bioinformatics support to life science researchers in Sweden. Present BILS staff has expertise in protein bioinformatics, mass spectrometry (MS), next generation sequencing (NGS), large-scale data handling, metagenomics, systems biology, and RNAseq. In this meeting BILS and how BILS staff can help out in research projects will be presented. We will also present a new web forum, biosupport.se

Place: room N460 (Naturvetarhuset)

EXTRA MIMS/UCMR Seminar

Speaker:
Felipe Cava Valenciano, PhD
Centro de Biologia Molecular "Severo Ochoa"
Universidad Autonoma de Madrid
Madrid. Spain

Title:
"Peptidoglycan plasticity in bacteria:
stress-induced peptidoglycan editing by non canonical D-amino acids"

Place: Major Groove (bldg. 6L, NUS), Department of Molecular Biology

Medical Biochemistry and Biophysics Seminar Series, autumn 2012
ATTENTION! NOTE DIFFERENT DAY, ROOM AND TIME!

Katarzyna Bebenek, NIEHS - NIH, USA

"A structural study of rNTP incorporation by a DNA polymerase"

Place: NOTE ROOM! lecture hall, KB3B1, Stora hörsalen, KBC

Host: Andrei Chabes

The "National and International" Seminar Series, autumn 2012

Dr. Birgitta Olofsson, Laboratory for Molecular Biology/Dept. of Zoology, Cambridge, UK

"Dining with C.elegans - how nutritional state affects foraging behaviour"

Place: lecture hall Betula, bldg. 6M, NUS-area

Host: Simon Tuck, Umeå Center for Molecular Biology

The "National and International" Seminar Series, autumn 2012

Dr. Junho Lee, Institute of Molecular Biology & Genetics, Seoul National University, South Korea

"Behaviour meets genetics in the nematode C.elegans: Cellular basis of a dispersal behaviour"

Place: lecture hall Betula, bldg. 6M, NUS-area

Host: Gautam Kao, Umeå Clinical Biomedical Research