Month
Date: Wednesday, May 25, 2016 12:00 - 13:00
Categories: Seminar *

Department of Chemistry Seminar

Speaker:
Aymelt Itzen
Professor, Department Chemistry, Group of Proteinchemistry, TU München, Germany

Title:
Molecular mechanisms of the manipulation of small GTPases in the context of bacterial infections

Abstract:

Intracellular signaling processes of eukaryotic cells are strictly coordinated spatially and temporally. Here, G-proteins of the class of small GTPases play a key regulatory role since they function as molecular switches that stimulate or inhibit intracellular signal progression. Due to the central role of small GTPases in the maintenance of cell homeostasis and in the response to changing environmental conditions, these proteins are frequently targeted by bacterial pathogens. Bacteria manipulate the activities of small GTPases in order to manifest an infection. In this talk, I will discuss molecular mechanisms of the manipulation of small GTPases and other essential intracellular proteins in the context of bacterial infection strategies. In particular, I will focus on the consequences of eukaryotic protein modifications (e.g. adenylylation, phosphocholination, proteolysis) caused by bacterial enzymes and will discuss their application potential.

 

Host: Christian Hedberg, Dept of Chemistry

 

Place: KBC, Lilla hörsalen, KB3A9