Affiliated research groups at Umeå Centre for Microbial Research.
The Read More link lead to the researchers personal homepage.
Molecular Biology
Bacteria-host interactions
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Created: Tuesday, 12 June 2007 12:33
Bernt Eric Uhlin
Our research is aimed at increasing the understanding of the mechanisms by which pathogenic E. coli and other enterobacteria express virulence-associated properties. We study molecular mechanisms behind expression and function of genes and gene products that contribute to the bacterial interactions with host environments.
 Read More (Bernt Eric Uhlin's group at Molecular Biology)
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PI: Bernt Eric Uhlin
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Molecular dissection of a new class of regulators of the microtubule-system as exemplified by Oncopr
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Created: Tuesday, 12 June 2007 12:33
Our research has been focused on identification of intracellular proteins with potential functions during signal transduction and growth control, which resulted in the identification of Oncoprotein 18/stathmin (Op18). The complex pattern of phosphorylation together with the observed up-regulation of Op18 in several types of human malignancies, suggested to us that this protein may have a central role in cell signaling. We have identified the function of Op18 as a phosphorylation-responsive regulator of microtubule dynamics and linked Op18 phosphorylation to regulation of microtubule dynamics in response to both external and cell cycle signals. Identification of homologous proteins reveals that Op18 represent a prototype of a new family of microtubule regulators.
Read More (Martin Gullberg at Molecular Biology)
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PI: Martin Gullberg
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The immune response in Drosophila
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Created: Tuesday, 12 June 2007 12:33
Our research is focused on the mechanisms of innate immunity, using Drosophila as a model system. This organism lacks lymphocytes and an acquired immune response, but has a well developed innate immune system. Studies of Drosophila have already contributed significantly to our understanding of innate immunity in humans. In addition, insect immunity is of great theoretical and practical importance in its own right, not least because insects are vectors for serious human diseases, and because insect pathogens are increasingly used to control agricultural pests.
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PI: Dan Hultmark
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Molecular mechanisms behind virulence factor expression and host interactions
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Created: Tuesday, 12 June 2007 12:33
The regulated expression of different virulence factors and the physiological adaptation to changing environmental conditions are essential for the ability of bacterial pathogens to cause infection and disease. In my research group we are studying Vibrio cholera and Escherichia coli as model organisms to elucidate molecular mechanisms behind virulence factor expression and host interactions.
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| PI: Sun Nyunt Wai |
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Environmental Signal Sensing and Integration
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Created: Tuesday, 12 June 2007 12:33
Research interests are centered on the underlying molecular mechanism by which bacteria perceive their surroundings and how they integrate and transduce multiple and sometimes conflicting signals to effect appropriate changes in their gene expression and ultimately their behavior.
Read More (Victoria Shingler's group at Molecular Biology)
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PI: Victoria Shingler
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