Affiliated research groups at Umeå Centre for Microbial Research.
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Molecular Biology
Antifungal Immunity
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Created: Saturday, 12 June 2010 12:33
Constantin Urban
Our group "Antifungal Immunity" is interested in the fundamental processes during infections with pathogenic fungi. We combine studies on how the innate immune system restricts the spread of fungal pathogens and how these microbes in turn react to the host environment.
 Read More (Constantin Urban´s group at Molecular Biology)
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PI: Constantin Urban
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Environmental Signal Sensing and Integration
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Created: Tuesday, 12 June 2007 12:33
Research interests are centered on the underlying molecular mechanism by which bacteria perceive their surroundings and how they integrate and transduce multiple and sometimes conflicting signals to effect appropriate changes in their gene expression and ultimately their behavior.
Read More (Victoria Shingler's group at Molecular Biology)
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PI: Victoria Shingler
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Molecular mechanisms behind virulence factor expression and host interactions
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Created: Tuesday, 12 June 2007 12:33
The regulated expression of different virulence factors and the physiological adaptation to changing environmental conditions are essential for the ability of bacterial pathogens to cause infection and disease. In my research group we are studying Vibrio cholera and Escherichia coli as model organisms to elucidate molecular mechanisms behind virulence factor expression and host interactions.
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| PI: Sun Nyunt Wai |
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Control of virulence by small regulatory RNAs in the human pathogen Listeria monocytogenes
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Created: Tuesday, 12 June 2007 12:33
Listeria monocytogenes is a gram-positive human pathogen causing several different diseases, like meningitis, septicaemia and abortions. Listeria has an unique ability to cross the intestinal barrier, the placental barrier and the blood-brain barrier during infection. The bacteria is able to invade most tissues and shows a specific cell-infection cycle
Read More (Jörgen Johansson's group at Molecular Biology)
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| PI: Jörgen Johansson |
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Studies on the importance of proteolytic activities for survival and pathogenicity of S.pyogenes
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Created: Tuesday, 12 June 2007 12:33
The Gram-positive bacterium Streptococcus pyogenes is one of the most common and important human bacterial pathogens. Streptococcal infections include throat and skin infections, which, although generally self-limiting, cause substantial morbidity and economic loss for society. 600 million people are estimated to suffer from streptococcal pharyngitis world wide. Invasive streptococcal infections are rare; however, about 3000 cases of severe cases are reported every year in Europe. Streptococcal infections are commonly localized to the mucosal epithelium of the respiratory tract or to epidermal skin layers. The establishment of these infections is characterized by an intense inflammatory state, a typical feature of streptococcal infections. Host-pathogen interactions of S. pyogenes in an inflammatory environment have so far only poorly been investigated, but are of great importance as uncontrolled inflammatory responses lead to serious life-threatening conditions such as the streptococcal toxic-shock syndrome. Our research aims to elucidate the role of streptococcal proteases in controlling inflammatory processes. These mechanisms are involved in severe clinical conditions, as well as in autoimmune disorders like rheumatoid arthritis; and in dermatoses like psoriasis. Since S. pyogenes infections are clinically highly significant, studies on the molecular interaction between S. pyogenes and proteins controlling inflammatory processes are of significant importance and essential to our understanding on the impact of bacterial infections on human physiology. Importantly, these findings connect underlying molecular mechanisms of significant inflammatory diseases with microbial pathogenesis. .
Read More Ulrich von Pawel-Rammingen's group at Molecular Biology)
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PI: Ulrich von Pawel-Rammingen
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