Research groups atÂ
the Laboratory for Molecular Infection Medicine Sweden (MIMS).
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RNA-mediated virulence regulation
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Created: Monday, 06 April 2009 15:14
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PI: Jörgen Johansson
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The intracellular pathogen Listeria monocytogenes has turned out to be a very important model for the study of host-pathogen interactions and bacterial adaptation to mammalian hosts.
We are studying different aspects of RNA-mediated virulence gene regulation in L. monocytogenes. By using different approaches, we identified several ncRNAs in the human bacterial pathogen Listeria monocytogenes. Several of them are involved in virulence by controlling different steps in the infection process, and their exact mechanism is currently being studied.
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Virulence mechanisms of the intracellular pathogen Francisella tularensis
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Created: Monday, 18 June 2007 03:00
he highly virulent Francisella tularensis proliferates in a wide range of phagocytic and non-phagocytic host cells and induces host cell death in macrophages. Although its genome recently was sequenced [Nature Genetics 37(2005)153], most of the factors allowing its intracellular replication still remain elusive. Another obstacle is the lack of genetic systems. There are three important recent discoveries regarding the features of cells infected with F. tularensis. i) Host cells are incapable of secreting proinflammatory cytopkines [Cell. Microbiol. 5(2003)41]. ii) F. tularensis rapidly escapes into the phagosome after uptake [Infect. Immun. 71(2003)5940]. iii) Monocytic cells eventually undergo apoptosis after infection [Infect. Immun. 71(2003)4642]. Moreover, we have established a model for F. tularensis in Drosophila melanogaster. Using this model, the iglC mutant is attenuated for virulence
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PI: Anders Sjöstedt
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Bacteria-host interactions
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Created: Tuesday, 12 June 2007 12:33
Our research is aimed at increasing the understanding of the mechanisms by which pathogenic /E. coli/ and other enterobacteria express virulence-associated properties. We study molecular mechanisms behind expression and function of genes and gene products that contribute to the bacterial interactions with host environments.
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PI: Bernt Eric Uhlin
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The Type III secretion system of pathogenic Yersinia
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Created: Tuesday, 12 June 2007 12:33
There are three human pathogenic strains of Yersinia; Y.pestis , Y.pseudotuberculosis and Y.enterocolitica . Y.pestis is the causative agent of plague; and was responsible for the Black death during the 14th century. This family of bacteria harbours a common virulence plasmid which encodes a number of secreted proteins collectively called Yops (Yersinia outer proteins). These proteins are expressed during infection and they are major antihost factors.
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PI: Hans Wolf-Watz
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Helicobacter pylori
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Created: Tuesday, 12 June 2007 12:33
Helicobacter pylori infection causes chronic active gastritis and peptic ulcer disease. In the western world, 10% of people (22.000.000 individuals) develop peptic ulcers. Furthermore, H. pylori infection is tightly correlated with development of gastric cancer with >500.000 mortalities/Y and, H. pylori has been defined a carcinogen by the WHO. The project studies protein-carbohydrate interactions that mediate adherence of H. pylori to stomach tissue. We focus on the Blood Group Antigen Binding Adhesin, BabA, which is the key player attachment protein that targets H. pylori binding to the stomach lining.
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PI: Thomas Borén
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