Affiliated research groups at Umeå Centre for Microbial Research.
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Chemistry

Design, Synthesis & Evaluation of novel antibacterial agents and protein aggregation inhibitors

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Created: Wednesday, 13 June 2007 03:00

Design, Synthesis & Evaluation of Ring fused 2-Pyridones Directed at Different Medicinal Targets and Diverse Oriented Synthesis (DOS) Towards New Heterocyclic Scaffolds.

A chemical platform with broad applications and flexibility has been rationally designed to interrupt complicated molecular machines important in microbial pathogenesis. The research programme contains a blend of computer-aided design, synthetic organic chemistry, molecular biology and genetics to investigate and disrupt complex biological systems important in disease processes.


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PI: Fredrik Almqvist

Solid-phase glycoconjugate synthesis and Type III secretion inhibitors

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Created: Tuesday, 12 June 2007 12:33

The research projects cover many aspects of organic chemistry with the aim to utilize small molecules to answer large questions in biology. The group is currently engaged in two major areas: solid-phase glycoconjugate synthesis and type III secretion inhibitors. The glycoconjugates are used in array applications with the aim to study microbial attachment. Type III secretion inhibitors can be used a stools to study bacterial virulence and as starting points for development of anti-infective drugs.


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PI: Mikael Elofsson

Structural studies on bio-molecules

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Created: Tuesday, 12 June 2007 12:33

The human tetrameric thyroid hormone-binding protein transthyretin belongs to a group of over 20 proteins that to cause disease by the formation of insoluble fibrils called amyloids. TTR is associated with two medical disorders: familial amyloidotic polyneuropathy (FAP) caused by mutations within the protein, and senile systemic polyneuropathy (SSA) that involves the native protein. FAP is prevalent in the northern parts of Sweden, where it is also referred to as "Skelleftesjukan". Amyloidosis involves structural changes within the amyloidogenic protein.


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PI: Elizabeth Sauer-Eriksson

BioCrystallography of Proteins involved in DNA and RNA interactions and muscle assembly

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Created: Tuesday, 12 June 2007 12:33

The aim of the work in my group is to understand the underlying physical principles of biomolecular organization and recognition. At the moment we focus on the following major areas: Proteins involved in nucleotide recognition (DNA, RNA and free nucleotides) and proteins involved in muscle assembly.


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PI: Uwe Sauer



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