Affiliated research groups at Umeå Centre for Microbial Research.
The Read More link lead to the researchers personal homepage.
Medical Biochemistry and Biophysics
Regulation of deoxyribonucleotide synthesis during DNA replication and repair in eukaryotes
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Created: Tuesday, 12 June 2007 12:33
Ribonucleotide reductase (RNR) plays a central role in the formation and control of the optimal levels of deoxyribonucleoside triphosphates, which are required for DNA replication and repair. In eukaryotic cells, both enzyme activity and the mRNAs encoding the two non-identical subunits, proteins R1 and R2, are cell cycle regulated with maximal levels during S phase.
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(Lars Thelander's group at Medical Biochemistry and Biophysics)
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PI: Lars Thelander
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Helicobacter pylori
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Created: Tuesday, 12 June 2007 12:33
Helicobacter pylori infection causes chronic active gastritis and peptic ulcer disease. In the western world, 10% of people (22.000.000 individuals) develop peptic ulcers. Furthermore, H. pylori infection is tightly correlated with development of gastric cancer with >500.000 mortalities/Y and, H. pylori has been defined a carcinogen by the WHO. The project studies protein-carbohydrate interactions that mediate adherence of H. pylori to stomach tissue. We focus on the Blood Group Antigen Binding Adhesin, BabA, which is the key player attachment protein that targets H. pylori binding to the stomach lining.
Read More (Thomas Borén's group at Medical Biochemistry and Biophysics)
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PI: Thomas Borén
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Helicobacter pylori. Molecular mechanisms and dynamics in adhesin expression during persistent infec
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Created: Tuesday, 12 June 2007 12:33
THE GASTRIC PATHOGEN Helicobacter pylori infects the human stomach of more than half of the world’s population and represents one of the most frequent causes of inflammatory processes in the stomach. The association of H. pylori infection and development of peptic ulcer disease and gastric cancer is well established.
ADHERENCE to the gastric epithelium is important for colonization and to establish a chronic infection. The gastric milieu changes during pathogenesis and H. pylori use different adherence proteins (adhesins) for interaction to healthy and inflamed gastric epithelium. The focus of our research is the mechanisms that are involved in the ability to adjust adhesin expression levels and the properties to cycle between an adherent and a non-adherent phenotype. We use the adhesin-receptor interactions, BabA and its interaction to ABO blood group antigens and the SabA adhesin and its interaction to the inflammation-associated receptor structures sialyl-Lewis x/a antigens.
Read More (Anna Arnqvist's group at Medical Biochemistry and Biophysics)
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PI: Anna Arnqvist
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dNTPs as cellular regulators
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Created: Tuesday, 12 June 2007 12:33
Andrei Chabes
Genetic information in most organisms is stored as DNA. DNA is synthesized from four building blocks, dNTPs. The DNA is constantly damaged either spontaneously or by environmental agents. If the damaged DNA is not repaired, it acquires mutations. Some mutations may cause genetic instability and cancer.
In eukaryotes, DNA damage leads to arrest of cell cycle, transcriptional activation of DNA repair genes, and apoptosis. These responses allow cells to survive the damage and repair the DNA.
Read More (Andrei Chabes' group at MIMS)
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PI: Andrei Chabes
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