In Dynamic Force Spectroscopy (DFS) we measure the small forces, in order of picoNewton, required to rupture single molecular bonds under gradually increasing loading. Important properties of specific molecular interaction, like unbinding forces, off-rates and binding energies can thereby be evaluated. We use force measuring optical tweezers which provides high-resolution force measurements on single cell level. We currently focus the research on characterization of the specific adhesion of the bacterial pathogen Helicobacter pylori. Read More

PI: Staffan Shedin