The human tetrameric thyroid hormone-binding protein transthyretin belongs to a group of over 20 proteins that to cause disease by the formation of insoluble fibrils called amyloids. TTR is associated with two medical disorders: familial amyloidotic polyneuropathy (FAP) caused by mutations within the protein, and senile systemic polyneuropathy (SSA) that involves the native protein. FAP is prevalent in the northern parts of Sweden, where it is also referred to as "Skelleftesjukan". Amyloidosis involves structural changes within the amyloidogenic protein. Read More

PI: Elizabeth Sauer-Eriksson