MIMS_UCMR Extra seminar

Speaker:
David A. Cisneros
IMP - Research Institute of Molecular Pathology
Vienna, Austria

Title:
"Bacterial secretion and eukaryotic chromosome segregation: Large molecular assemblies at work"

Place: Major Groove, Department of Molecular Biology, Bldg L, NUS Campus
Host: Bernt Eric Uhlin

Abstract:

Work is defined as the operation of a force in producing movement or other physical change. My research has mainly focused in understanding how large protein complexes interact structurally and biochemically to produce this kind of work.
I will first discuss the correlation of molecular dynamic simulations with biochemical data, which I used to study the intermediate steps of assembly of the type II secretion system. This system is a large multi-protein complex that secretes folded proteins from the periplasm of Gram-negative bacteria to the extracellular space.
I will then discuss the cohesin complex. In eukaryotic cells, this complex forms a ring with a diameter of ~50 nm that is thought to topologically entrap the two sister chromatids after DNA replication. During metaphase, the cohesin complex ensures sister chromatid bi-orientation, which allows their equal segregation. I am using Cas9 genome engineering and super-resolution microscopy to study its assembly before and after replication.

The lifespan of humans is steadily increasing in most countries, which will have fundamental implications for our society in the future. World-leading scientists discuss this development, in a meeting commemorating the 275 year anniversary of the Royal Swedish Academy of Sciences.

Place: Aula Nordica
Organiser: The Royal Swedish Academy of Sciences 
Kontaktperson:This email address is being protected from spambots. You need JavaScript enabled to view it.

On 2-3 June, the Royal Swedish Academy of Sciences will hold a symposium on the subject of aging together with Umeå University. Some important issues on future population levels as well as what happens in your brain and body with age will be raised. The event takes place in Aula Nordica at Umeå University and is open to the public and free of charge – please register before 26 May.

The Royal Swedish Academy of Sciences celebrates its 275 year anniversary this year and it is no coincidence that Umeå has been chosen to host the event as several of its members of the presiding committee can be found in Umeå. Already a year ago the question of a celebration in Umeå was posed to the Academy.

Lars Nyberg, head of the Umeå Center for Functional Brain Imaging (UFBI), says that he suggested aging as the theme since research at several faculties at Umeå University has a strong connection with aging.

"Aging is something that affects everyone. Many countries have a largely aging population and many elderly are stricken with metabolic disease and diabetes. What are the consequences and wherein are the challenges when it comes to aging in the future?" Lars Nyberg asks himself.

The symposium will be held in English and is entitled "Aging of societies, bodies, and minds: trends, evolution of functions, and health". Chairs for the two days are researchers at Umeå University and members of the Academy: Gunnar Malmberg, Professor of Applied Geography, Helena Edlund, Professor of Molecular and Developmental Biology, Professor Emeritur Hans-Wolf Watz, Bernt Eric Uhlin, Professor of Medical Microbiology, and Lars Nyberg, Professor of Psychology and Neuroscience. Professor Emerita, Marianne Rasmuson, will also contribute.

Speakers from Harvard University, Vienna Institute of Demography, University College of London and University of California have also been invited.

Would you like to know more?

Read more about the symposium and register before 26 May.

More information and programme here: http://www.kva.se/sv/Kalendariumlista/20151/aging-of-societies-bodies-and-minds-trends-evolution-of-functions-and-health

The event is free of charge and open to the public but registration is required for all participants. (Registration form is found further down at this website). Please note that registration is binding. 

The lifespan of humans is steadily increasing in most countries, which will have fundamental implications for our society in the future. World-leading scientists discuss this development, in a meeting commemorating the 275 year anniversary of the Royal Swedish Academy of Sciences.

Place: Aula Nordica
Organiser: The Royal Swedish Academy of Sciences 
Kontaktperson:This email address is being protected from spambots. You need JavaScript enabled to view it.

On 2-3 June, the Royal Swedish Academy of Sciences will hold a symposium on the subject of aging together with Umeå University. Some important issues on future population levels as well as what happens in your brain and body with age will be raised. The event takes place in Aula Nordica at Umeå University and is open to the public and free of charge – please register before 26 May.

The Royal Swedish Academy of Sciences celebrates its 275 year anniversary this year and it is no coincidence that Umeå has been chosen to host the event as several of its members of the presiding committee can be found in Umeå. Already a year ago the question of a celebration in Umeå was posed to the Academy.

Lars Nyberg, head of the Umeå Center for Functional Brain Imaging (UFBI), says that he suggested aging as the theme since research at several faculties at Umeå University has a strong connection with aging.

"Aging is something that affects everyone. Many countries have a largely aging population and many elderly are stricken with metabolic disease and diabetes. What are the consequences and wherein are the challenges when it comes to aging in the future?" Lars Nyberg asks himself.

The symposium will be held in English and is entitled "Aging of societies, bodies, and minds: trends, evolution of functions, and health". Chairs for the two days are researchers at Umeå University and members of the Academy: Gunnar Malmberg, Professor of Applied Geography, Helena Edlund, Professor of Molecular and Developmental Biology, Professor Emeritur Hans-Wolf Watz, Bernt Eric Uhlin, Professor of Medical Microbiology, and Lars Nyberg, Professor of Psychology and Neuroscience. Professor Emerita, Marianne Rasmuson, will also contribute.

Speakers from Harvard University, Vienna Institute of Demography, University College of London and University of California have also been invited.

Would you like to know more?

Read more about the symposium and register before 26 May.

More information and programme here: http://www.kva.se/sv/Kalendariumlista/20151/aging-of-societies-bodies-and-minds-trends-evolution-of-functions-and-health

The event is free of charge and open to the public but registration is required for all participants. (Registration form is found further down at this website). Please note that registration is binding. 

The lifespan of humans is steadily increasing in most countries, which will have fundamental implications for our society in the future. World-leading scientists discuss this development, in a meeting commemorating the 275 year anniversary of the Royal Swedish Academy of Sciences.

Place: Aula Nordica
Organiser: The Royal Swedish Academy of Sciences 
Kontaktperson:This email address is being protected from spambots. You need JavaScript enabled to view it.

On 2-3 June, the Royal Swedish Academy of Sciences will hold a symposium on the subject of aging together with Umeå University. Some important issues on future population levels as well as what happens in your brain and body with age will be raised. The event takes place in Aula Nordica at Umeå University and is open to the public and free of charge – please register before 26 May.

The Royal Swedish Academy of Sciences celebrates its 275 year anniversary this year and it is no coincidence that Umeå has been chosen to host the event as several of its members of the presiding committee can be found in Umeå. Already a year ago the question of a celebration in Umeå was posed to the Academy.

Lars Nyberg, head of the Umeå Center for Functional Brain Imaging (UFBI), says that he suggested aging as the theme since research at several faculties at Umeå University has a strong connection with aging.

"Aging is something that affects everyone. Many countries have a largely aging population and many elderly are stricken with metabolic disease and diabetes. What are the consequences and wherein are the challenges when it comes to aging in the future?" Lars Nyberg asks himself.

The symposium will be held in English and is entitled "Aging of societies, bodies, and minds: trends, evolution of functions, and health". Chairs for the two days are researchers at Umeå University and members of the Academy: Gunnar Malmberg, Professor of Applied Geography, Helena Edlund, Professor of Molecular and Developmental Biology, Professor Emeritur Hans-Wolf Watz, Bernt Eric Uhlin, Professor of Medical Microbiology, and Lars Nyberg, Professor of Psychology and Neuroscience. Professor Emerita, Marianne Rasmuson, will also contribute.

Speakers from Harvard University, Vienna Institute of Demography, University College of London and University of California have also been invited.

Would you like to know more?

Read more about the symposium and register before 26 May.

More information and programme here: http://www.kva.se/sv/Kalendariumlista/20151/aging-of-societies-bodies-and-minds-trends-evolution-of-functions-and-health

The event is free of charge and open to the public but registration is required for all participants. (Registration form is found further down at this website). Please note that registration is binding.