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BEGIN:VEVENT
UID:20190510T120000UTC-7ff3ce@http://www.ucmr.umu.se/
DTSTAMP:20260914T123329Z
CATEGORIES:Seminar
DESCRIPTION:<p><span style='color: #ff0000\;'><strong>Note Room Change!</st
 rong></span></p>\n<p><strong>National and International Seminar Series Spr
 ing 2019</strong></p>\n<p>Speaker:<br /><strong>Lukas Kenner</strong><br /
 >Ludwig Boltzmann Inst for Cancer Research\, Vienna\, Austria</p>\n<p>Titl
 e:<br /><strong>Genetics\, transcriptional factors and models in preclinic
 al studies of prostate cancer</strong></p>\n<p>Host: Jenny Persson</p>\n<p
 ><strong>Room: Major Groove\, Bldg 6L\, NUS</strong></p>\n<p><em>Coffee/te
 a/cookies served 30 min before start</em></p>\n<p><em>Please contact respe
 ctive host for enquiries to meet with speaker<br />General questions regar
 ding the seminar series\; please contact <span id='cloak6c8ea06cdb00fb6899
 5a5f9fa332c1be'>This email address is being protected from spambots. You n
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DTSTART;TZID=Europe/Stockholm:20190510T140000
DTEND;TZID=Europe/Stockholm:20190510T140000
SUMMARY:Nat and Internat Seminar Series - Genetics\, transcriptional factor
 s and models in preclinical studies of prostate cancer
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/
 577-nat-and-internat-seminar-series-genetics-transcriptional-factors-and-m
 odels-in-preclinical-studies-of-prostate-cancer.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:<p><span style='color: #ff0000\;'><strong>Note
  Room Change!</strong></span></p>\n<p><strong>National and International S
 eminar Series Spring 2019</strong></p>\n<p>Speaker:<br /><strong>Lukas Ken
 ner</strong><br />Ludwig Boltzmann Inst for Cancer Research\, Vienna\, Aus
 tria</p>\n<p>Title:<br /><strong>Genetics\, transcriptional factors and mo
 dels in preclinical studies of prostate cancer</strong></p>\n<p>Host: Jenn
 y Persson</p>\n<p><strong>Room: Major Groove\, Bldg 6L\, NUS</strong></p>
 \n<p><em>Coffee/tea/cookies served 30 min before start</em></p>\n<p><em>Pl
 ease contact respective host for enquiries to meet with speaker<br />Gener
 al questions regarding the seminar series\; please contact <span id='cloak
 6c8ea06cdb00fb68995a5f9fa332c1be'>This email address is being protected fr
 om spambots. You need JavaScript enabled to view it.</span><script type='t
 ext/javascript'>
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END:VEVENT
BEGIN:VEVENT
UID:20190517T120000UTC-17e850@http://www.ucmr.umu.se/
DTSTAMP:20260914T123329Z
CATEGORIES:Seminar
DESCRIPTION:<p><span style='color: #ff0000\;'><strong>NOTE ROOM CHANGE!</st
 rong></span></p>\n<p>National and International Seminar Series Spring 2019
 </p>\n<p>Speaker:<br /><strong>Derek Doherty<br /></strong>Trinity College
 \, Dublin\, Ireland</p>\n<p>Title:<br /><strong>Targeting CD1d for cancer 
 immunotherapy</strong></p>\n<p>Host: Johan Normark</p>\n<p><strong><span s
 tyle='color: #ff0000\;'>Place: Major Groove\, Dept of Molecular Biology\, 
 bldg 6L NUS</span></strong></p>\n<p><em>Coffee/tea/cookies served 30 min b
 efore start</em></p>\n<p><em>Please contact respective host for enquiries 
 to meet with speaker<br />General questions regarding the seminar series\;
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DTSTART;TZID=Europe/Stockholm:20190517T140000
DTEND;TZID=Europe/Stockholm:20190517T150000
SUMMARY:Nat and Internat Seminar Series - Targeting CD1d for cancer immunot
 herapy
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/
 569-nat-and-internat-seminar-series-targeting-cd1d-for-cancer-immunotherap
 y.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:<p><span style='color: #ff0000\;'><strong>NOTE
  ROOM CHANGE!</strong></span></p>\n<p>National and International Seminar S
 eries Spring 2019</p>\n<p>Speaker:<br /><strong>Derek Doherty<br /></stron
 g>Trinity College\, Dublin\, Ireland</p>\n<p>Title:<br /><strong>Targeting
  CD1d for cancer immunotherapy</strong></p>\n<p>Host: Johan Normark</p>\n<
 p><strong><span style='color: #ff0000\;'>Place: Major Groove\, Dept of Mol
 ecular Biology\, bldg 6L NUS</span></strong></p>\n<p><em>Coffee/tea/cookie
 s served 30 min before start</em></p>\n<p><em>Please contact respective ho
 st for enquiries to meet with speaker<br />General questions regarding the
  seminar series\; please contact <span id='cloak42c5ad75f3509935406c9fc2a1
 428d00'>This email address is being protected from spambots. You need Java
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END:VEVENT
BEGIN:VEVENT
UID:20190524T120000UTC-6be1b2@http://www.ucmr.umu.se/
DTSTAMP:20260914T123329Z
CATEGORIES:Seminar
DESCRIPTION:<p><span style='color: #ff0000\;'><strong>NOTE ROOM CHANGE!</st
 rong></span></p>\n<p>National and International Seminar Series Spring 2019
 </p>\n<p>Speaker:<br /><strong>Oriol Gallego</strong><br />Pompeu Fabra\, 
 Barcelona\, Spain</p>\n<p>Title:<br /><strong> Towards the elusive mechani
 sm of exocytosis: doing structural biology in living cells </strong></p>\n
 <p>Host: Franscesca Aguiló</p>\n<p><span style='color: #ff0000\;'><strong>
 Room: Major Groove\, Dept of Molecular Biology\, Bldg 6L\, NUS</strong></s
 pan></p>\n<p><em>Coffee/tea/cookies served 30 min before start</em></p>\n<
 p><em>Please contact respective host for enquiries to meet with speaker<br
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DTSTART;TZID=Europe/Stockholm:20190524T140000
DTEND;TZID=Europe/Stockholm:20190524T150000
SUMMARY:Nat and Internat Seminar Series -Towards the elusive mechanism of e
 xocytosis: doing structural biology in living cells
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/
 570-nat-and-internat-seminar-series-towards-the-elusive-mechanism-of-exocy
 tosis-doing-structural-biology-in-living-cells.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:<p><span style='color: #ff0000\;'><strong>NOTE
  ROOM CHANGE!</strong></span></p>\n<p>National and International Seminar S
 eries Spring 2019</p>\n<p>Speaker:<br /><strong>Oriol Gallego</strong><br 
 />Pompeu Fabra\, Barcelona\, Spain</p>\n<p>Title:<br /><strong> Towards th
 e elusive mechanism of exocytosis: doing structural biology in living cell
 s </strong></p>\n<p>Host: Franscesca Aguiló</p>\n<p><span style='color: #f
 f0000\;'><strong>Room: Major Groove\, Dept of Molecular Biology\, Bldg 6L\
 , NUS</strong></span></p>\n<p><em>Coffee/tea/cookies served 30 min before 
 start</em></p>\n<p><em>Please contact respective host for enquiries to mee
 t with speaker<br />General questions regarding the seminar series\; pleas
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END:VEVENT
BEGIN:VEVENT
UID:20190528T091500UTC-fabaaa@http://www.ucmr.umu.se/
DTSTAMP:20260914T123329Z
CATEGORIES:Seminar
DESCRIPTION:<p>Department of Molecular Biology/MIMS<br />Extra Seminar</p>
 \n<p>Speaker:<br /><strong>Himanshu Sharma<br /></strong>Indian Institute 
 of Technology Guwahati\, Assam\, India</p>\n<p>Title:<br /><strong>Ribosom
 e assembly defects abrogate initiation factor mediated inspection of start
  codon</strong></p>\n<p>Host:<br />Jonas Barandun\, MIMS group leader and 
 SciLifeLab National Fellow\, Department of Molecular Biology</p>\n<p>Room:
  Thymine\, Dept Molecular Biology\, NUS\, bldg 6K/L 2 stairs up</p>\n<p><s
 trong>Abstract:</strong><br />Faithful protein synthesis is ensured by ext
 ensive quality control checkpoints using components of the translational m
 achinery. However\, the implications of defective ribosome assembly on pro
 tein synthesis and the associated translation quality control mechanisms i
 n bacteria remain grossly unaddressed. In this study\, using E. coli as a 
 model organism we show that premature ribosomes evade scrutiny of cognate 
 start Codon by initiation factors during translation initiation. Resultant
 ly the defective ribosomes make way into the translation cycle with severe
 ly compromised decoding and protein synthesis capabilities. The enfeebled 
 binding of premature ribosomes to initiation factors also licenses the rap
 id conversion of the 30S (pre) initiation complex to 70S initiation comple
 x. Overall\, our work highlights that a mass balance deficit between prema
 ture ribosomes and initiation factors steers the entry of premature riboso
 mes into the translation cycle.<br />(Co-Author: B. Anand)</p>
DTSTART;TZID=Europe/Stockholm:20190528T111500
DTEND;TZID=Europe/Stockholm:20190528T121500
SUMMARY:Ribosome assembly defects abrogate initiation factor mediated inspe
 ction of start codon
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/
 578-ribosome-assembly-defects-abrogate-initiation-factor-mediated-inspecti
 on-of-start-codon.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:<p>Department of Molecular Biology/MIMS<br />E
 xtra Seminar</p>\n<p>Speaker:<br /><strong>Himanshu Sharma<br /></strong>I
 ndian Institute of Technology Guwahati\, Assam\, India</p>\n<p>Title:<br /
 ><strong>Ribosome assembly defects abrogate initiation factor mediated ins
 pection of start codon</strong></p>\n<p>Host:<br />Jonas Barandun\, MIMS g
 roup leader and SciLifeLab National Fellow\, Department of Molecular Biolo
 gy</p>\n<p>Room: Thymine\, Dept Molecular Biology\, NUS\, bldg 6K/L 2 stai
 rs up</p>\n<p><strong>Abstract:</strong><br />Faithful protein synthesis i
 s ensured by extensive quality control checkpoints using components of the
  translational machinery. However\, the implications of defective ribosome
  assembly on protein synthesis and the associated translation quality cont
 rol mechanisms in bacteria remain grossly unaddressed. In this study\, usi
 ng E. coli as a model organism we show that premature ribosomes evade scru
 tiny of cognate start Codon by initiation factors during translation initi
 ation. Resultantly the defective ribosomes make way into the translation c
 ycle with severely compromised decoding and protein synthesis capabilities
 . The enfeebled binding of premature ribosomes to initiation factors also 
 licenses the rapid conversion of the 30S (pre) initiation complex to 70S i
 nitiation complex. Overall\, our work highlights that a mass balance defic
 it between premature ribosomes and initiation factors steers the entry of 
 premature ribosomes into the translation cycle.<br />(Co-Author: B. Anand)
 </p>
END:VEVENT
BEGIN:VEVENT
UID:20190529T113000UTC-5e80d8@http://www.ucmr.umu.se/
DTSTAMP:20260914T123329Z
CATEGORIES:Seminar
DESCRIPTION:<p><strong>Department of Molecular Biology/MIMS</strong><br />E
 xtra Seminar</p>\n<p><strong>Magnus Ölander</strong><br />Department of Ph
 armacy\, Uppsala University<br />Title:<br /><strong>Proteomic and functio
 nal analysis of </strong><br /><strong><em>in vitro</em> systems for studi
 es of drug disposition in the human small intestine and liver</strong></p>
 \n<p><br />Place: Thymine\, Molecular Biology bldg. 6K/L (2 stairs up)</p>
 \n<p>Host: Barbara Sixt\, MIMS group leader\,&nbsp\; Dept of Molecular Bio
 logy</p>\n<p>&nbsp\;</p>
DTSTART;TZID=Europe/Stockholm:20190529T133000
DTEND;TZID=Europe/Stockholm:20190529T143000
SUMMARY:Proteomic and functional analysis of in vitro systems for studies o
 f drug disposition in the human small intestine and liver
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/
 579-proteomic-and-functional-analysis-of-in-vitro-systems-for-studies-of-d
 rug-disposition-in-the-human-small-intestine-and-liver.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:<p><strong>Department of Molecular Biology/MIM
 S</strong><br />Extra Seminar</p>\n<p><strong>Magnus Ölander</strong><br /
 >Department of Pharmacy\, Uppsala University<br />Title:<br /><strong>Prot
 eomic and functional analysis of </strong><br /><strong><em>in vitro</em> 
 systems for studies of drug disposition in the human small intestine and l
 iver</strong></p>\n<p><br />Place: Thymine\, Molecular Biology bldg. 6K/L 
 (2 stairs up)</p>\n<p>Host: Barbara Sixt\, MIMS group leader\,&nbsp\; Dept
  of Molecular Biology</p>\n<p>&nbsp\;</p>
END:VEVENT
END:VCALENDAR