Seminar - Jürg Müller: Molecular mechanisms of the Polycom/trithorax system
Fri. 1 Jun, 2012 15:00
The "National and International" Seminar Series, spring 2012
Jürg Müller, Max Planck Institute of Biochemistry, Martinsried, Germany
"Molecular mechanisms of the Polycom/trithorax system"
Place: Lecture hall Betula, bldg. 6M, NUS
Host: Yuri Schwartz, Molecular Biology
Tue. 5 Jun, 2012
Seminar - Mark Petronczki: Closing the gap between the mitotic spindle and plasma membrane during cytokinesis
Tue. 5 Jun, 2012 15:15
Medical Biochemistry and Biophysics Seminar Series, spring 2012
Mark Petronczki, Cancer Research UK - London Research Institute, United Kingdom
"Closing the gap between the mitotic spindle and plasma membrane during cytokinesis"
Place: KB3A9, Lilla hörsalen, KBC
Host: Andrei Chabes
Fri. 8 Jun, 2012
Seminar - Martin Welch: Metabolic regulation of type III secretion in Pseudomonas aeruginosa biofilms and the role of type III secretion in cystic fibrosis pathology
Fri. 8 Jun, 2012 15:00
The "National and International" Seminar Series, spring 2012
Martin Welch, University of Cambridge, UK
"Metabolic regulation of type III secretion in Pseudomonas aeruginosa biofilms and the role of type III secretion in cystic fibrosis pathology"
Place: Lecture hall "Betula", bldg. 6M, NUS area
Host: Madeleine Ramstedt, Department of Chemistry
Tue. 12 Jun, 2012
Seminar - Jacques Le Pendu: Adaptation of Caliciviruses to histo-blood group antigens diversity and potential involvement in host-pathogen co-evolution
Tue. 12 Jun, 2012 15:15
Medical Biochemistry and Biophysics Seminar Series, spring 2012
Jacques Le Pendu, INSERM, Universite de Nantes, Nantes, France
"Adaptation of Caliciviruses to histo-blood group antigens diversity and potential involvement in host-pathogens co-evolution"
Place: KB3A9, Lilla hörsalen, KBC
Host: Thomas Borén
Thu. 14 Jun, 2012
Seminar - Thomas Geissman: Bacterial pathogenesis and innate immunity
Thu. 14 Jun, 2012 15:00
Extra Seminar - Department of Molecular Biology
Thomas Geissman, Bacterial pathogenesis and innate immunityFaculté de Médecine Laennec, Lyon, France "RNAIII of Staphylococcus aureus and its role in cell wall homeostasis"
Place: room Thymine, Department of Molecular Biology, NUS Area, bldg 6L
Host: Jörgen Johansson
Fri. 15 Jun, 2012
Thesis Defence - Jonas Gripenland: Regulatory roles of two small RNAs in the human pathogen Listeria monocytogeneses and Evaluation of an alternative infection model
Fri. 15 Jun, 2012 10:00 - 12:30
Thesis Defence
Jonas Gripenland, Department of Molecular Biology
"Regulatory roles of two small RNAs in the human pathogen Listeria monocytogenes and Evaluation of an alternative infection model"
Place: Major Groove, bldg. 6L, NUS
Opponent: Thomas Geissmann, Associate Professor, Université de Lyon, Frankrike.
Supervisor: Jörgen Johansson, Department of Molecular Biology
Seminar - Kazuya Kikuchi: Design, synthesis and biological application of in vivo imaging probes with tunablechemical switches
Fri. 15 Jun, 2012 13:30
KBC-Seminar
Kazuya Kikuchi, Osaka University, Graduate School of Engineering, WPI-Immunology Frontier Research Center, Osaka, Japan "Design, synthesis and biological application of in vivo imaging probes with tunable chemical switches"
Place: KB3B1, Stora hörsalen, KBC
Host: Gunnar Öquist, Department of Plant Physiology
Abstract: One of the great challenges in the post-genome era is to clarify the biological significance of intracellular molecules directly in living cells. If we can image a molecule in action, it is possible to acquire biological information, which is unavailable if we deal with cell homogenates. One possible approach is to design and synthesize chemical probes that can convert biological information to chemical output. Protein fluorescent labeling provides an attractive approach to study the localization and function of proteins in living cells. Recently, a specific pair of a protein tag and its ligand has been utilized to visualize a protein of interest (POI). In this method, a POI is fused with a protein tag and the tag is labeled with the ligand connected to a fluorescent molecule. The advantage of this protein labeling system is that a variety of fluorescent molecules are potentially available as labeling reagents, and that the protein tag is conditionally labeled with its fluorescent ligand. I have designed a protein labeling system that allows fluorophores to be linked to POI. The protein tag (BL-tag) is a mutant class A ?-lactamase (TEM-1) modified to be covalently bound to the designed specific labeling probes and the labeling probes is consisted with a ?-lactam ring (ampicillin, cephalosporin) attached to various fluorophores. A fluorogenetic labeling system can be designed using the unique property of cephalosporin, which release leaving group by subsequent reaction after opening the lactam ring. For further sophisticated application, multicolor imaging was done by adopting the colorful fluorophores.
Seminar - Janne Lehtiö: Defining human proteome using high resolution peptide isoelectric focusing coupled to mass spectrometry (HiRIEF-LC-MS) and the application of this method to improve cancer treatment
Fri. 15 Jun, 2012 15:00 - 16:00
Umeå Plant Science Centre Seminar
Janne Lehtiö, Karolinska Institute, Stockholm
"Defining human proteome using high resolution peptide isoelectric focusing coupled to mass spectrometry (HiRIEF-LC-MS) and the application of this method to improve cancer treatment "
Place: Lilla hörsalen, KB3A9
Host: Anders Nordström, Department of Molecular Biology
Wed. 20 Jun, 2012
Seminar - Anders Grönlund: Modeling intracellular regulation: Transcription factor kinetics
Wed. 20 Jun, 2012 15:00 - 16:00
UPSC, Department of Plant Physiology
Speaker: Anders Grönlund new assoc. lector in biological modelling at the department
Abstract: Basic physical constraints in how macromolecules are made and how fast they can find each other in the intracellular environment constrain the fidelity of cellular regulation. These two properties are recently studied experimentally as well as analytically. I will give a brief overview of how such processes can be characterized and modeled.
Place: KB3A9 Lilla hörsalen, KBC
Thu. 21 Jun, 2012
Seminar - Graham Mann: Melanoma risk, outcome and targeted therapy - genomics changes the game
Thu. 21 Jun, 2012 10:00
Medical Biochemistry and Biophysics Seminar Series, spring 2012
Graham Mann, University of Sydney Cancer Research, Westmead Institute for Cancer Research, Westmead Millennium Institute and Melanoma Institute Australia "Melanoma risk, outcome and targeted therapy - genomics changes the game"