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UID:fcff57de413469ed91fc3ae8e8f5e4dchttp://www.ucmr.umu.se
DTSTAMP:20260621T154428Z
CATEGORIES:General
DESCRIPTION:<strong>Medical Biochemistry and Biophysics Seminar Series\, au
 tumn 2012</strong><br /><br /><strong>Örjan Carlborg</strong>\, Dept. of C
 linical Sciences\, Division of Computational Genetics\, Swedish University
  of Agricultural Sciences\, Uppsala\, Sweden<br /><br /><strong><span styl
 e='font-size: 10pt\;'><span style='font-family: Calibri\,Verdana\,Helvetic
 a\,Arial\;'>'Understanding the genetic architecture of complex traits</spa
 n>'</span></strong><br /><br /><strong>Place:</strong> lecture hall KB3A9\
 , Lilla hörsalen\, KBC<br /><br /><strong>Host:</strong> Andrei Chabes<spa
 n style='font-family: Calibri\,Verdana\,Helvetica\,Arial\;'></span><br /><
 br /><strong>Abstract</strong><br /><span style='font-family: Calibri\,Ver
 dana\,Helvetica\,Arial\; font-size: 10pt\;'>Understanding how genes contri
 bute to the phenotypic variability  observed in populations is a major cha
 llenge in biology. A common  approach to dissect the genetics of complex t
 raits is to measure the  genotype of individuals in a population at a larg
 e number  of loci across the genome and then evaluate whether the phenotyp
 ic mean  differs between the individuals that carry particular combination
 s of  genetic variants\, alleles\, at either individual loci (i.e. detecti
 on of  additive\, dominance and epigenetic effects  of loci) or at multipl
 e loci (i.e. to detect genetic interactions or  epistasis). I will here gi
 ve a brief introduction to this topic and  illustrate the insights that ca
 n be gained into the genetics of complex  traits using these approaches by
  using examples  from our research in domestic animals. An alternative\, a
 nd promising\,  strategy to identify genes involved in gene-by-gene or  ge
 ne-by-environment interactions is to search for loci that causes a  differ
 ence in variance (a variance heterogeneity) between genotypes.  This talk 
 will be concluded by presenting some recent work to develop  theory and to
 ols for genome-wide mapping of individual  variance-controlling loci. Empi
 rical findings from studies of data in <em>Arabidopsis thaliana</em> and <
 em>Saccharomyces cerevisiae</em> will be  used to illustrate the contribut
 ion of such loci to the genetic  architecture of complex traits and the im
 plications of the findings on  our understanding of the genetic regulation
  of complex  trait variation.</span>
DTSTART;TZID=Europe/Stockholm:20120904T151500
DTEND;TZID=Europe/Stockholm:20120904T151500
SUMMARY:Seminar - Örjan Carlborg: Understanding the genetic architecture of
  complex traits
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/165-general/
 228-seminar-oerjan-carlborg-understanding-the-genetic-architecture-of-comp
 lex-traits.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:<strong>Medical Biochemistry and Biophysics Se
 minar Series\, autumn 2012</strong><br /><br /><strong>Örjan Carlborg</str
 ong>\, Dept. of Clinical Sciences\, Division of Computational Genetics\, S
 wedish University of Agricultural Sciences\, Uppsala\, Sweden<br /><br /><
 strong><span style='font-size: 10pt\;'><span style='font-family: Calibri\,
 Verdana\,Helvetica\,Arial\;'>'Understanding the genetic architecture of co
 mplex traits</span>'</span></strong><br /><br /><strong>Place:</strong> le
 cture hall KB3A9\, Lilla hörsalen\, KBC<br /><br /><strong>Host:</strong> 
 Andrei Chabes<span style='font-family: Calibri\,Verdana\,Helvetica\,Arial\
 ;'></span><br /><br /><strong>Abstract</strong><br /><span style='font-fam
 ily: Calibri\,Verdana\,Helvetica\,Arial\; font-size: 10pt\;'>Understanding
  how genes contribute to the phenotypic variability  observed in populatio
 ns is a major challenge in biology. A common  approach to dissect the gene
 tics of complex traits is to measure the  genotype of individuals in a pop
 ulation at a large number  of loci across the genome and then evaluate whe
 ther the phenotypic mean  differs between the individuals that carry parti
 cular combinations of  genetic variants\, alleles\, at either individual l
 oci (i.e. detection of  additive\, dominance and epigenetic effects  of lo
 ci) or at multiple loci (i.e. to detect genetic interactions or  epistasis
 ). I will here give a brief introduction to this topic and  illustrate the
  insights that can be gained into the genetics of complex  traits using th
 ese approaches by using examples  from our research in domestic animals. A
 n alternative\, and promising\,  strategy to identify genes involved in ge
 ne-by-gene or  gene-by-environment interactions is to search for loci that
  causes a  difference in variance (a variance heterogeneity) between genot
 ypes.  This talk will be concluded by presenting some recent work to devel
 op  theory and tools for genome-wide mapping of individual  variance-contr
 olling loci. Empirical findings from studies of data in <em>Arabidopsis th
 aliana</em> and <em>Saccharomyces cerevisiae</em> will be  used to illustr
 ate the contribution of such loci to the genetic  architecture of complex 
 traits and the implications of the findings on  our understanding of the g
 enetic regulation of complex  trait variation.</span>
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