Seminar - Stephen Albert Johnston: Technologies to transform healthcare
Friday, May 25, 2012 15:00
This event does not repeat
The "National and International" Seminar Series, spring 2012
Stephen Albert Johnston, Center for Innovations in Medicine Biodesign, Arizona State University
"Technologies to transform healthcare"
Place: Lecture hall Betula, Bldg. 6M, NUS
Host: Anders Sjöstedt, Clinical Microbiology
UCMR Mini-Symposium
Tuesday, May 29, 2012 8:30 - 11:45
This event does not repeat
UCMR Mini-Symposium
Research projects and networks at the Laboratories for Chemical Biology Umeå (LCBU) and X-ray crystallography research within UCMR research groups. The symposium is open to everyone and no registration is required.
Seminar - Leonor David: Regulation of mucin glycoproteome in gastric carcinogenesis
Tuesday, May 29, 2012 15:15
This event does not repeat
Medical Biochemistry and Biophysics Seminar Series, spring 2012
Leonor David, IPATIMUP, Medical Faculty of the University of Porto, Portugal
"Regulation of mucin glycoproteome in gastric carcinogenesis"
Place: Lecture hall KB3A9, Lilla hörsalen, KBC
Host: Thomas Borén
Seminar - Jürg Müller: Molecular mechanisms of the Polycom/trithorax system
Friday, June 01, 2012 15:00
This event does not repeat
The "National and International" Seminar Series, spring 2012
Jürg Müller, Max Planck Institute of Biochemistry, Martinsried, Germany
"Molecular mechanisms of the Polycom/trithorax system"
Place: Lecture hall Betula, bldg. 6M, NUS
Host: Yuri Schwartz, Molecular Biology
Seminar - Mark Petronczki: Closing the gap between the mitotic spindle and plasma membrane during cytokinesis
Tuesday, June 05, 2012 15:15
This event does not repeat
Medical Biochemistry and Biophysics Seminar Series, spring 2012
Mark Petronczki, Cancer Research UK - London Research Institute, United Kingdom
"Closing the gap between the mitotic spindle and plasma membrane during cytokinesis"
Place: KB3A9, Lilla hörsalen, KBC
Host: Andrei Chabes
Seminar - Martin Welch: Metabolic regulation of type III secretion in Pseudomonas aeruginosa biofilms and the role of type III secretion in cystic fibrosis pathology
Friday, June 08, 2012 15:00
This event does not repeat
The "National and International" Seminar Series, spring 2012
Martin Welch, University of Cambridge, UK
"Metabolic regulation of type III secretion in Pseudomonas aeruginosa biofilms and the role of type III secretion in cystic fibrosis pathology"
Place: Lecture hall "Betula", bldg. 6M, NUS area
Host: Madeleine Ramstedt, Department of Chemistry
Seminar - Jacques Le Pendu: Adaptation of Caliciviruses to histo-blood group antigens diversity and potential involvement in host-pathogen co-evolution
Tuesday, June 12, 2012 15:15
This event does not repeat
Medical Biochemistry and Biophysics Seminar Series, spring 2012
Jacques Le Pendu, INSERM, Universite de Nantes, Nantes, France
"Adaptation of Caliciviruses to histo-blood group antigens diversity and potential involvement in host-pathogens co-evolution"
Place: KB3A9, Lilla hörsalen, KBC
Host: Thomas Borén
Seminar - Thomas Geissman: Bacterial pathogenesis and innate immunity
Thursday, June 14, 2012 15:00
This event does not repeat
Extra Seminar - Department of Molecular Biology
Thomas Geissman, Bacterial pathogenesis and innate immunityFaculté de Médecine Laennec, Lyon, France "RNAIII of Staphylococcus aureus and its role in cell wall homeostasis"
Place: room Thymine, Department of Molecular Biology, NUS Area, bldg 6L
Host: Jörgen Johansson
Thesis Defence - Jonas Gripenland: Regulatory roles of two small RNAs in the human pathogen Listeria monocytogeneses and Evaluation of an alternative infection model
Friday, June 15, 2012 10:00 - 12:30
This event does not repeat
Thesis Defence
Jonas Gripenland, Department of Molecular Biology
"Regulatory roles of two small RNAs in the human pathogen Listeria monocytogenes and Evaluation of an alternative infection model"
Place: Major Groove, bldg. 6L, NUS
Opponent: Thomas Geissmann, Associate Professor, Université de Lyon, Frankrike.
Supervisor: Jörgen Johansson, Department of Molecular Biology
Seminar - Kazuya Kikuchi: Design, synthesis and biological application of in vivo imaging probes with tunablechemical switches
Friday, June 15, 2012 13:30
This event does not repeat
KBC-Seminar
Kazuya Kikuchi, Osaka University, Graduate School of Engineering, WPI-Immunology Frontier Research Center, Osaka, Japan "Design, synthesis and biological application of in vivo imaging probes with tunable chemical switches"
Place: KB3B1, Stora hörsalen, KBC
Host: Gunnar Öquist, Department of Plant Physiology
Abstract: One of the great challenges in the post-genome era is to clarify the biological significance of intracellular molecules directly in living cells. If we can image a molecule in action, it is possible to acquire biological information, which is unavailable if we deal with cell homogenates. One possible approach is to design and synthesize chemical probes that can convert biological information to chemical output. Protein fluorescent labeling provides an attractive approach to study the localization and function of proteins in living cells. Recently, a specific pair of a protein tag and its ligand has been utilized to visualize a protein of interest (POI). In this method, a POI is fused with a protein tag and the tag is labeled with the ligand connected to a fluorescent molecule. The advantage of this protein labeling system is that a variety of fluorescent molecules are potentially available as labeling reagents, and that the protein tag is conditionally labeled with its fluorescent ligand. I have designed a protein labeling system that allows fluorophores to be linked to POI. The protein tag (BL-tag) is a mutant class A ?-lactamase (TEM-1) modified to be covalently bound to the designed specific labeling probes and the labeling probes is consisted with a ?-lactam ring (ampicillin, cephalosporin) attached to various fluorophores. A fluorogenetic labeling system can be designed using the unique property of cephalosporin, which release leaving group by subsequent reaction after opening the lactam ring. For further sophisticated application, multicolor imaging was done by adopting the colorful fluorophores.
Seminar - Graham Mann: Melanoma risk, outcome and targeted therapy - genomics changes the game
Thursday, June 21, 2012 10:00
This event does not repeat
Medical Biochemistry and Biophysics Seminar Series, spring 2012
Graham Mann, University of Sydney Cancer Research, Westmead Institute for Cancer Research, Westmead Millennium Institute and Melanoma Institute Australia "Melanoma risk, outcome and targeted therapy - genomics changes the game"
Place: KB3A9, Lilla hörsalen, KBC
Host: Andrei Chabes
Thesis Defence - Christina Schönherr: Anaplastic Lymphoma Kinase mutations and downstream signalling
Friday, August 24, 2012 9:00 - 11:30
This event does not repeat
Thesis Defence
Christina Schönherr, Department of Molecular Biology
"Anaplastic Lymphoma Kinase mutation and downstream signalling"
Place: Betula, NUS-area
Opponent: Dr. Aristidis Moustakas, Docent, Ludwig Institute for Cancer Research, Uppsala Universitet Supervisor: Ruth Palmer
Seminar - Hans Bos: Rap and Integrin mediated cell adhesion
Friday, August 24, 2012 15:00
This event does not repeat
The "National and International" Seminar Series, autumn 2012
Dr. Hans Bos, Dept. Molecular Cancer Research, University Medical Centre Utrecht, Netherlands
IceLab Seminar Series - Sandeep Krishna and Andreas Grönlund
Thursday, August 30, 2012 15:00 - 16:00
This event does not repeat
IceLab welcomes you to our interdisciplinary seminar series with two short presentations, coffee, and cake!
Presentations: Benefits of cooperation and communication in bacteria by Sandeep Krishna and Modeling intracellular regulation: Transcription factor kinetics by Andreas Grönlund (details below).
Place: IceLab (www.org.umu.se/icelab/english/) - located in the NA-building (Naturvetarhuset), floor 3 near the skywalk from Universum
Abstracts: "Benefits of cooperation and communication in bacteria" Sandeep Krishna, National Centre for Biological Sciences, Bangalore, India
Individual bacteria excrete many common goods, such as exoenzymes, siderophores, biofilm products and virulence factors, which can benefit the functioning and growth of not only themselves but also other individuals in their surroundings. I'll discuss how the functional form of this benefit affects the decision of whether to turn on or turn off production of the common good, and how communication between bacteria may then become crucial for making such decisions correctly.
"Modeling intracellular regulation: Transcription factor kinetics" Andreas Grönlund, UPSC, Umeå University
Basic physical constraints in how macromolecules are made and how fast they can find each other in the intracellular environment constrain the fidelity of cellular regulation. These two properties are recently studied experimentally as well as analytically. I will give a brief overview of how such processes can be characterized and modeled.
Seminar - Terje Larsen: Strategies for Improving cardiac metabolism and function in obesity/type 2 diabetes
Friday, August 31, 2012 15:00
This event does not repeat
The "National and International" Seminar Series, autumn 2012
Prof. Terje Larsen, Institute of Medical Biology, University of Tromso, Norway
"Strategies for Improving cardiac metabolism and function in obesity/type 2 diabetes"
Place: Lecture Hall Betula, bldg. 6M, NUS-area
Host: Stefan Nilsson, Medical Biosciences
Seminar - Örjan Carlborg: Understanding the genetic architecture of complex traits
Tuesday, September 04, 2012 15:15
This event does not repeat
Medical Biochemistry and Biophysics Seminar Series, autumn 2012
Örjan Carlborg, Dept. of Clinical Sciences, Division of Computational Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
"Understanding the genetic architecture of complex traits"
Place: lecture hall KB3A9, Lilla hörsalen, KBC
Host: Andrei Chabes
Abstract Understanding how genes contribute to the phenotypic variability observed in populations is a major challenge in biology. A common approach to dissect the genetics of complex traits is to measure the genotype of individuals in a population at a large number of loci across the genome and then evaluate whether the phenotypic mean differs between the individuals that carry particular combinations of genetic variants, alleles, at either individual loci (i.e. detection of additive, dominance and epigenetic effects of loci) or at multiple loci (i.e. to detect genetic interactions or epistasis). I will here give a brief introduction to this topic and illustrate the insights that can be gained into the genetics of complex traits using these approaches by using examples from our research in domestic animals. An alternative, and promising, strategy to identify genes involved in gene-by-gene or gene-by-environment interactions is to search for loci that causes a difference in variance (a variance heterogeneity) between genotypes. This talk will be concluded by presenting some recent work to develop theory and tools for genome-wide mapping of individual variance-controlling loci. Empirical findings from studies of data in Arabidopsis thaliana and Saccharomyces cerevisiae will be used to illustrate the contribution of such loci to the genetic architecture of complex traits and the implications of the findings on our understanding of the genetic regulation of complex trait variation.
Thesis Defence - Pramod Kumar Rompikuntal: Outer membrane vesicle-mediated export of virulence factors from Gram-negative bacteria
Friday, September 07, 2012 9:00 - 11:30
This event does not repeat
Thesis Defence
Pramod Kumar Rompikuntal, Department of Molecular Biology
"Outer membrane vesicle-mediated export of virulence factors from Gram-negative bacteria"
Place: Astrid Fagraeus-salen (A103), bldgs. 6A-L, NUS
Opponent: Professor Ann-Beth Jonsson, University of Stockholm
Supervisor: Sun Nyunt Wai, Department of Molecular Biology
Seminar - Denise Monack: Chronic Salmonella carriage is controlled by a host regulator of fatty acid metabolism PPARdelta
Friday, September 07, 2012 15:00
This event does not repeat
The "National and International" Seminar Series, autumn 2012
Dr. Denise Monack, Dept. of Microbiology and Immunology, Stanford University, California, USA
"Chronic Salmonella carriage is controlled by a host regulator of fatty acid metabolism PPARdelta"
Place: lecture hall Betula, bldg. 6M, NUS-area
Host: Anders Sjösted, Clinical Microbiology
Seminar - Henrik Strahl: From a passive envelope to a highly organized scaffold: The active role of the cell membrane in bacterial growth and division
Tuesday, September 11, 2012 15:15
This event does not repeat
Extra Seminar - MIMS/UCMR
Henrik Strahl, The Centre for Bacterial Cell Biology, Newcastle University, UK
"From a passive envelope to a highly organized scaffold: The active role of the cell membrane in bacterial growth and division."
Place: Major Groove, bldg. 6L, NUS-area
Host: Bernt Eric Uhlin, Department of Molecular Biology
Double Seminar: Ting Xie and Francois Guillemot
Friday, September 14, 2012 14:00
This event does not repeat
The "National and International" Seminar Series, autumn 2012
Dr. Ting Xie, Stowers Institute for Medical Research, Kansas City, USA "Stern Cells: Niche, Competition, Aging and Potential Application"
Host: Leif Carlsson, Umeå Center for Molecular Medicine
AND
Dr. Francois Guillemot, MRC National Institute for Medical Research, Mill Hill, London, UK "Transcriptional controll of stern cell activity in the mouse brain"
Hosts: Tanushree Pandit/Lena Gunhaga, Umeå Center for Molecular Medicine
Place (both seminars): lecture hall Betula, bldg. 6M, NUS-area NOTE TIME! The first seminar will start at 14.00!