Department of Chemistry Seminar
\nSpeaker:
Professor\, Department Chemistry\, Group of
Proteinchemistry\, TU Mü\;nchen\, Germany
Title:
Abstract:
\nIntracellular signaling processes of eukaryotic cells are strictly coordinated spatially and temporally. Here\, G-proteins of the class of small GTPases play a ke y regulatory role since they function as molecular switches that stimulate or inhibit intracellular signal progression. Due to the central role of s mall GTPases in the maintenance of cell homeostasis and in the response to changing environmental conditions\, these proteins are frequently targete d by bacterial pathogens. Bacteria manipulate the activities of small GTPa ses in order to manifest an infection. In this talk\, I will discuss molec ular mechanisms of the manipulation of small GTPases and other essential i ntracellular proteins in the context of bacterial infection strategies. In particular\, I will focus on the consequences of eukaryotic protein modif ications (e.g. adenylylation\, phosphocholination\, proteolysis) caused by bacterial enzymes and will discuss their application potential.
\n& nbsp\;
\nHost: Christian Hedberg\, Dept of Chemistry
\n\;
\nPlace: KBC\, Lilla hö\;rsalen\, KB3A9
DTSTART;TZID=Europe/Stockholm:20160525T120000 DTEND;TZID=Europe/Stockholm:20160525T130000 SUMMARY:Seminar - Aymelt Itzen: Molecular mechanisms of the manipulation of small GTPases in the context of bacterial infections URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 421-seminar-aymelt-itzen-molecular-mechanisms-of-the-manipulation-of-small -gtpases-in-the-context-of-bacterial-infections.html X-ALT-DESC;FMTTYPE=TEXT/HTML:Department of Chemistry Seminar
\nSpe
aker:
Aymelt Itzen
Professor\, Department Che
mistry\, Group of Proteinchemistry\, TU Mü\;nchen\, Germany
Ti
tle:
Molecular mechanisms of the manipulation of small GTPas
es in the context of bacterial infections
Abstract:
\nIntracellular signaling processes of eukaryotic cells are strictly coor dinated spatially and temporally. Here\, G-proteins of the class of small GTPases play a key regulatory role since they function as molecular switch es that stimulate or inhibit intracellular signal progression. Due to the central role of small GTPases in the maintenance of cell homeostasis and i n the response to changing environmental conditions\, these proteins are f requently targeted by bacterial pathogens. Bacteria manipulate the activit ies of small GTPases in order to manifest an infection. In this talk\, I w ill discuss molecular mechanisms of the manipulation of small GTPases and other essential intracellular proteins in the context of bacterial infecti on strategies. In particular\, I will focus on the consequences of eukaryo tic protein modifications (e.g. adenylylation\, phosphocholination\, prote olysis) caused by bacterial enzymes and will discuss their application pot ential.
\n\;
\nHost: Christian Hedberg\, Dept of Chemistry
\n\;
\nPlace: KBC\, Lilla hö\;rsalen\, KB3A9
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