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UID:20150601T110000UTC-1ca290@http://www.ucmr.umu.se/
DTSTAMP:20260412T023155Z
CATEGORIES:Seminar
DESCRIPTION:<p>MIMS_UCMR Extra seminar</p>\n<p>Speaker:<br /><strong>David 
 A. Cisneros</strong><br />IMP - Research Institute of Molecular Pathology<
 br />Vienna\, Austria</p>\n<p>Title:<br />'<strong>Bacterial secretion and
  eukaryotic chromosome segregation: Large molecular assemblies at work</st
 rong>'</p>\n<p>Place: Major Groove\, Department of Molecular Biology\, Bld
 g L\, NUS Campus<br />Host: Bernt Eric Uhlin</p>\n<p><strong>Abstract:</st
 rong></p>\n<p>Work is defined as the operation of a force in producing mov
 ement or other physical change. My research has mainly focused in understa
 nding how large protein complexes interact structurally and biochemically 
 to produce this kind of work.<br />I will first discuss the correlation of
  molecular dynamic simulations with biochemical data\, which I used to stu
 dy the intermediate steps of assembly of the type II secretion system. Thi
 s system is a large multi-protein complex that secretes folded proteins fr
 om the periplasm of Gram-negative bacteria to the extracellular space.<br 
 />I will then discuss the cohesin complex. In eukaryotic cells\, this comp
 lex forms a ring with a diameter of ~50 nm that is thought to topologicall
 y entrap the two sister chromatids after DNA replication. During metaphase
 \, the cohesin complex ensures sister chromatid bi-orientation\, which all
 ows their equal segregation. I am using Cas9 genome engineering and super-
 resolution microscopy to study its assembly before and after replication.<
 /p>
DTSTART;TZID=Europe/Stockholm:20150601T130000
DTEND;TZID=Europe/Stockholm:20150601T140000
SUMMARY:David A. Cisneros: Bacterial secretion and eukaryotic chromosome se
 gregation: Large molecular assemblies at work
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/
 396-david-a-cisneros-bacterial-secretion-and-eukaryotic-chromosome-segrega
 tion-large-molecular-assemblies-at-work.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:<p>MIMS_UCMR Extra seminar</p>\n<p>Speaker:<br
  /><strong>David A. Cisneros</strong><br />IMP - Research Institute of Mol
 ecular Pathology<br />Vienna\, Austria</p>\n<p>Title:<br />'<strong>Bacter
 ial secretion and eukaryotic chromosome segregation: Large molecular assem
 blies at work</strong>'</p>\n<p>Place: Major Groove\, Department of Molecu
 lar Biology\, Bldg L\, NUS Campus<br />Host: Bernt Eric Uhlin</p>\n<p><str
 ong>Abstract:</strong></p>\n<p>Work is defined as the operation of a force
  in producing movement or other physical change. My research has mainly fo
 cused in understanding how large protein complexes interact structurally a
 nd biochemically to produce this kind of work.<br />I will first discuss t
 he correlation of molecular dynamic simulations with biochemical data\, wh
 ich I used to study the intermediate steps of assembly of the type II secr
 etion system. This system is a large multi-protein complex that secretes f
 olded proteins from the periplasm of Gram-negative bacteria to the extrace
 llular space.<br />I will then discuss the cohesin complex. In eukaryotic 
 cells\, this complex forms a ring with a diameter of ~50 nm that is though
 t to topologically entrap the two sister chromatids after DNA replication.
  During metaphase\, the cohesin complex ensures sister chromatid bi-orient
 ation\, which allows their equal segregation. I am using Cas9 genome engin
 eering and super-resolution microscopy to study its assembly before and af
 ter replication.</p>
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