National and International Seminar Series 2015
\nSpeak
er:
Jérome Dejardin
Institute of Human Genetics
\, Montpellier\, France
Title: Heterchromatin replication
timing is controlled by SMCHD1
Host: Yuri Schwartz\,
Molbiol
Room: Betula\, bldg 6M
National and International Seminar Series 2 015
\nSpeaker:
Jérome Dejardin
Institute
of Human Genetics\, Montpellier\, France
Title: Heterchrom
atin replication timing is controlled by SMCHD1
Host:
Yuri Schwartz\, Molbiol
Room: Betula\, bldg 6M
National and International Seminar Series 2015
\nSpeak er:
\nRolf OhlssonKarolinska Institute\, Stockholm
\nTitle
Transcriptional coordination and the loss of it in cancer: New insights
in the role of higher order chromatin structures
Room: Betula\, bl dg 6M\, NUS Campus
\nHost: Jan Larsson\, Molbiol
DTSTART;TZID=Europe/Stockholm:20150320T150000 DTEND;TZID=Europe/Stockholm:20150320T160000 SUMMARY:Nat. and Internat Seminar Series - Rolf Ohlsson:Transcriptional coo rdination and the loss of it in cancer: New insights in the role of higher order chromatin structures URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 388-nat-and-internat-seminar-series-rolf-ohlsson-transcriptional-coordinat ion-and-the-loss-of-it-in-cancer-new-insights-in-the-role-of-higher-order- chromatin-structures.html X-ALT-DESC;FMTTYPE=TEXT/HTML:National and International Seminar Series 2 015
\nSpeaker:
\nRolf OhlssonKarolinska Institute\, Stockholm< /p>\n
Title
Transcriptional coordination and the loss of it in canc
er: New insights in the role of higher order chromatin structures
Room: Betula\, bldg 6M\, NUS Campus
\nHost: Jan Larsson\, Molbiol
END:VEVENT BEGIN:VEVENT UID:20150323T090000UTC-bc4c6f@http://www.ucmr.umu.se/ DTSTAMP:20260604T234055Z CATEGORIES:Seminar DESCRIPTION:Medical Biochemistry and Biophysics seminar:
Tu
esday 24 March 15.15 KB3A9 Lilla hörsalen\, KBC
Department of Medica
l Biochemistry and Biophysics Seminar Series
Speaker:
<
strong>Hans Spelbrink
Radboud University Medical Centre\, N
ijmegen\, The Netherlands.
Title: Nucleoids and nucle
oid associated proteins
Host: Sjoerd Wanrooij\, Medi
cal Biochemistry and Biophysics
Room: Lilla hörsalen\, KB3A9<
/p>
DTSTART;TZID=Europe/Stockholm:20150323T100000
DTEND;TZID=Europe/Stockholm:20150323T110000
SUMMARY:Seminar - Hans Spelbrink: Nucleoids And Nucleoid Associated Protein
s
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/
393-seminar-hans-spelbrink-nucleoids-and-nucleoid-associated-proteins.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:
Medical Biochemistry and Biophysics seminar
:
Tuesday 24 March 15.15 KB3A9 Lilla hörsalen\, KBC
Dep
artment of Medical Biochemistry and Biophysics Seminar Series
Speaker:
Hans Spelbrink
Radboud University M
edical Centre\, Nijmegen\, The Netherlands.
Title: Nu
cleoids and nucleoid associated proteins
Host: Sjoer
d Wanrooij\, Medical Biochemistry and Biophysics
Room: Lilla
hörsalen\, KB3A9
Department of Medical Biochemistry and Biophysics
\nEx tra Seminar
\nSpeaker:
\nKerstin Lindblad-Toh
Broad Institute of MIT and Harvard\, Cambridge\, Massachusetts\, Uni
ted States of America
Science for Life Laboratory\, Dept. of Medical
Biochemistry and Microbiology\, Uppsala University\, Uppsala\, Sweden
Title:
Studying human disease and vertebrate evolution using co
mparative genetics and genomics.
Room Lilla hörsalen\, KB3A9\,
KBC
Host: Erik Johansson\, Medchem
Department of Medical Biochemistry and Biop hysics
\nExtra Seminar
\nSpeaker:
\nKerstin Lind
blad-Toh
Broad Institute of MIT and Harvard\, Cambridge\, Ma
ssachusetts\, United States of America
Science for Life Laboratory\,
Dept. of Medical Biochemistry and Microbiology\, Uppsala University\, Upps
ala\, Sweden
Title:
Studying human disease and vertebrate ev
olution using comparative genetics and genomics.
Room Lilla hör
salen\, KB3A9\, KBC
Host: Erik Johansson\, Medchem
Speaker:
Dr. Cynthia M. Sharma
Re
search Centre for Infectious Diseases (ZINF)
University of Würzburg\n
Title:
'Regulatory RNAs in the pathogenic Epsilonprote
obacteria\, Helicobacter pylori and Campylobacter jejuni
'
Place: Old Library\, Dept of Molecular Biology (6
L building)
Host: Sun Nyunt Wai\, Dept. Molecular Biology
DTSTART;TZID=Europe/Stockholm:20150327T133000 DTEND;TZID=Europe/Stockholm:20150327T143000 SUMMARY:EXTRA Seminar - Cynthia M. Sharma: Regulatory RNAs in the pathogeni c Epsilonproteobacteria\, Helicobacter pylori and Campylobacter jejuni URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 392-extra-seminar-cynthia-m-sharma-regulatory-rnas-in-the-pathogenic-epsil onproteobacteria-helicobacter-pylori-and-campylobacter-jejuni.html X-ALT-DESC;FMTTYPE=TEXT/HTML:Speaker:
Dr. Cynthia M. Sharma
Research Centre for Infectious Diseases (ZINF)
Univers
ity of Würzburg
Title:
'Regulatory RNAs in the pathog
enic Epsilonproteobacteria\, Helicobacter pylori and Campylob
acter jejuni'
Place: Old Library\, Dept of Mol
ecular Biology (6L building)
Host: Sun Nyunt Wai\, Dept. Molecular Biology
END:VEVENT BEGIN:VEVENT UID:20150327T140000UTC-21e460@http://www.ucmr.umu.se/ DTSTAMP:20260604T234055Z CATEGORIES:Seminar DESCRIPTION:National and International Serminar Series
\n\n
Speaker:Gunnar Nilsson
Karolinska Institute\, Stock
holm
Title:
Mast cells – a hinge between innate and a
daptive immunity
\n
Place: Betula\, NUS bldg 6M
\nHost Jose Petdro Lopez\, Clinical Microbiology
DTSTART;TZID=Europe/Stockholm:20150327T150000 DTEND;TZID=Europe/Stockholm:20150327T160000 SUMMARY:Nat. and Internat Seminar Series - Gunnar Nilsson: Mast cells – a h inge between innate and adaptive immunity URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 389-nat-and-internat-seminar-series-gunnar-nilsson-mast-cells-a-hinge-betw een-innate-and-adaptive-immunity.html X-ALT-DESC;FMTTYPE=TEXT/HTML:National and International Serminar Series< /p>\n
\n
Speaker:Gunnar Nilsson
Karolinska
Institute\, Stockholm
Title:
Mast cells – a hinge bet
ween innate and adaptive immunity
\n
Place: Betula \, NUS bldg 6M
\nHost Jose Petdro Lopez\, Clinical Microbiology
END:VEVENT BEGIN:VEVENT UID:20150410T130000UTC-e5287a@http://www.ucmr.umu.se/ DTSTAMP:20260604T234055Z CATEGORIES:Seminar DESCRIPTION:Nat. an Internat Seminar Series
\nSpeaker:
Instituto de Biomedicina de Sevilla (IBI
S)
Title:
Understanding ribosome biogenesis in euk
aryotes
Place: Betula\, NUS\, bldg 6 M
Host: T racy Nissan\, molbiol
DTSTART;TZID=Europe/Stockholm:20150410T150000 DTEND;TZID=Europe/Stockholm:20150410T150000 SUMMARY:Nat.and Internat. Seminar Series - Jesus de la Cruz: “Understanding ribosome biogenesis in eukaryotes URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 390-nat-and-internat-seminar-series-jesus-de-la-cruz-understanding-ribosom e-biogenesis-in-eukaryotes.html X-ALT-DESC;FMTTYPE=TEXT/HTML:Nat. an Internat Seminar Series
\nSpe
aker:
Jesus de la Cruz
Instituto de Biomedicin
a de Sevilla (IBIS)
Title:
Understanding ribosome
biogenesis in eukaryotes
Place: Betula\, NUS\, bldg 6
M
Host: Tracy Nissan\, molbiol
END:VEVENT BEGIN:VEVENT UID:20150601T110000UTC-1ca290@http://www.ucmr.umu.se/ DTSTAMP:20260604T234055Z CATEGORIES:Seminar DESCRIPTION:MIMS_UCMR Extra seminar
\nSpeaker:
David
A. Cisneros
IMP - Research Institute of Molecular Pathology<
br />Vienna\, Austria
Title:
'Bacterial secretion and
eukaryotic chromosome segregation: Large molecular assemblies at work'
Place: Major Groove\, Department of Molecular Biology\, Bld
g L\, NUS Campus
Host: Bernt Eric Uhlin
Abstract:
\nWork is defined as the operation of a force in producing mov
ement or other physical change. My research has mainly focused in understa
nding how large protein complexes interact structurally and biochemically
to produce this kind of work.
I will first discuss the correlation of
molecular dynamic simulations with biochemical data\, which I used to stu
dy the intermediate steps of assembly of the type II secretion system. Thi
s system is a large multi-protein complex that secretes folded proteins fr
om the periplasm of Gram-negative bacteria to the extracellular space.
I will then discuss the cohesin complex. In eukaryotic cells\, this comp
lex forms a ring with a diameter of ~50 nm that is thought to topologicall
y entrap the two sister chromatids after DNA replication. During metaphase
\, the cohesin complex ensures sister chromatid bi-orientation\, which all
ows their equal segregation. I am using Cas9 genome engineering and super-
resolution microscopy to study its assembly before and after replication.<
/p>
DTSTART;TZID=Europe/Stockholm:20150601T130000
DTEND;TZID=Europe/Stockholm:20150601T140000
SUMMARY:David A. Cisneros: Bacterial secretion and eukaryotic chromosome se
gregation: Large molecular assemblies at work
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/
396-david-a-cisneros-bacterial-secretion-and-eukaryotic-chromosome-segrega
tion-large-molecular-assemblies-at-work.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:
MIMS_UCMR Extra seminar
\nSpeaker:
David A. Cisneros
IMP - Research Institute of Mol
ecular Pathology
Vienna\, Austria
Title:
'Bacter
ial secretion and eukaryotic chromosome segregation: Large molecular assem
blies at work'
Place: Major Groove\, Department of Molecu
lar Biology\, Bldg L\, NUS Campus
Host: Bernt Eric Uhlin
Work is defined as the operation of a force
in producing movement or other physical change. My research has mainly fo
cused in understanding how large protein complexes interact structurally a
nd biochemically to produce this kind of work.
I will first discuss t
he correlation of molecular dynamic simulations with biochemical data\, wh
ich I used to study the intermediate steps of assembly of the type II secr
etion system. This system is a large multi-protein complex that secretes f
olded proteins from the periplasm of Gram-negative bacteria to the extrace
llular space.
I will then discuss the cohesin complex. In eukaryotic
cells\, this complex forms a ring with a diameter of ~50 nm that is though
t to topologically entrap the two sister chromatids after DNA replication.
During metaphase\, the cohesin complex ensures sister chromatid bi-orient
ation\, which allows their equal segregation. I am using Cas9 genome engin
eering and super-resolution microscopy to study its assembly before and af
ter replication.
Speaker:
\nChristophe d'Enfert
\n< p>Fungal Biology and Pathogenicity Unit - INRA USC2019\n
Host: Constantin Urban
\nRoom: Betula\, bldg 6M\, NUS
DTSTART;TZID=Europe/Stockholm:20150924T150000 DTEND;TZID=Europe/Stockholm:20150924T160000 SUMMARY:UCMR/MIMS Mini-Symposium on Fungal Infections URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 397-ucmr-mims-mini-symposium-on-fungal-infections.html X-ALT-DESC;FMTTYPE=TEXT/HTML:Speaker:
\nChristophe d'Enfer t
\nFungal Biology and Pathogenicity Unit - INRA USC2019 Department of Mycology\,
Institut Pasteur 25\, Paris\,
Fra
nce
\n
Host: Constantin Urban
\nRoom: Betula\, bldg 6 M\, NUS
END:VEVENT BEGIN:VEVENT UID:20151214T140000UTC-b3a88c@http://www.ucmr.umu.se/ DTSTAMP:20260604T234055Z CATEGORIES:Seminar DESCRIPTION:MIMS Extra Seminar
\nSpeaker:
\nFranz Na
rberhaus
Department of Microbial Biology
Ruhr-Universit
ä\;t Bochum
Germany
Title:
Unusual phospholi
pid biosynthesis pathways and RNA thermometers in bacteria
Host: Emmanuelle Charpentier
DTSTART;TZID=Europe/Stockholm:20151214T150000 DTEND;TZID=Europe/Stockholm:20151214T160000 SUMMARY:MIMS Extra Seminar - Franz Narberhaus: Unusual phospholipid biosynt hesis pathways and RNA thermometers in bacteria URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 404-mims-extra-seminar-franz-narberhaus-unusual-phospholipid-biosynthesis- pathways-and-rna-thermometers-in-bacteria.html X-ALT-DESC;FMTTYPE=TEXT/HTML:MIMS Extra Seminar
\nSpeaker:
\nFranz Narberhaus
Department of Microbial Biology
Ruhr-Universitä\;t Bochum
Germany
Title:
Unusual phospholipid biosynthesis pathways and RNA thermometers in bacteri
a
Room: Seminar Room Thymine\, Department of Molecu
lar Biology
Host: Emmanuelle Charpentier
END:VEVENT BEGIN:VEVENT UID:20160216T141500UTC-613d79@http://www.ucmr.umu.se/ DTSTAMP:20260604T234055Z CATEGORIES:Seminar DESCRIPTION:MIMS- UCMR Seminar Medical Biochemistry and Biophysics Semin ar
\nSpeaker:
Oliver Billker
Wellcome T
rust Sanger Institute\, Cambridge\, United Kingdom.
Title:
<
strong>'Regulating a complex life cycle &mdash\; New molecular tools revea
l mechanisms of malaria parasite transmission by mosquitoes'.
Host: Bernt Eric Uhlin
\n\;
\nPlace: Lilla hö\;r salen KB3A9\, KBC
DTSTART;TZID=Europe/Stockholm:20160216T151500 DTEND;TZID=Europe/Stockholm:20160216T161500 SUMMARY:Seminar - Oliver Billker: Regulating a complex life cycle — New mol ecular tools reveal mechanisms of malaria parasite transmission by mosquit oes URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 407-seminar-oliver-billker-regulating-a-complex-life-cycle-new-molecular-t ools-reveal-mechanisms-of-malaria-parasite-transmission-by-mosquitoes.html X-ALT-DESC;FMTTYPE=TEXT/HTML:MIMS- UCMR Seminar Medical Biochemistry and Biophysics Seminar
\nSpeaker:
Oliver Billker
Wellcome Trust Sanger Institute\, Cambridge\, United Kingdom.
Title:
'Regulating a complex life cycle &mdash\; New mole
cular tools reveal mechanisms of malaria parasite transmission by mosquito
es'.
Host: Bernt Eric Uhlin
\n\;
\nPlace : Lilla hö\;rsalen KB3A9\, KBC
END:VEVENT BEGIN:VEVENT UID:20160218T140000UTC-3ac68c@http://www.ucmr.umu.se/ DTSTAMP:20260604T234055Z CATEGORIES:Seminar DESCRIPTION:Department of Chemistry
Seminar
Speaker:
<
span>Professor Dr. Christian P. R. Hackenberger
Hum
boldt Universitä\;t zu Berlin
and
Leibniz-Institut fü\
;r Molekulare Pharmakologie (FMP)
Title:
Place: Lilla hö\;rsalen\, KB3A9
Host: Chr
istian Hedberg\, Department of Chemistry
Abstr
act:
Our lab constantly aims to identify new bioorthogonal
reactions for the synthesis and modification of functional peptides and p
roteins. We apply these highly selective organic reactions to study functi
onal consequences of naturally occurring posttranslational protein modific
ations (PTMs) as well as to generate novel peptide- and protein-conjugates
for pharmaceutical and medicinal applications.(1)
In the first pa rt of this lecture\, our recent efforts in the synthesis and analysis of n aturally occurring labile PTMs including the synthesis of site-specificall y phosphorylated Lys-peptides (pLys) using the Staudinger-phosphite reacti on (2a) as well as phosphorylated Cys-peptides (pCys)\, (2b) will be prese nted.
\nIn the second part of this presentation\, I will focus on th
e cellular delivery of modified functional proteins. Thereby\, we employ c
yclic cell penetrating peptides (cCPPs) to transport a functional full len
gth protein to the cytosol of living cells as recently demonstrated by the
direct delivery of GFP-conjugates.(3) For protein modification we use a c
ombined approach of intein expression\, bioorthogonal reactions and recent
ly developed enzymatic ligations\, called Tub-tag labeling.4 This concept
is finally applied to generate site-specifically labelled cell permeable n
anobodies\, i.e. small antigen binding proteins that remain active within
the reductive milieu inside living cells\, to interfere with intracellular
targets.
References
(1.) D. Schumache
r\, C.P.R. Hackenberger\, Curr. Opin. Chem. Biol. 2014\, 22\, 62-69.
(2.) a)J. Bertran-Vicente\, R.A. Serwa\, M. Schü\;mann\, P. Sc
hmieder\, E. Krause\, C.P.R. Hackenberger\, J. Am Chem. Soc. 2014\, 136\,
13622-13628\;
(b) J. Bertran-Vicente\, M. Penkert\, O. Nieto\, M. Schü\;mann\, P. Schmieder\, E. Krause\, C.P.R. Hackenberger\, submitte d.
\n(3.) N. Nischan\, H.D. Herce\, F. Natale\, N. Bohlke\, N. Budis a\, M.C. Cardoso\, C.P.R. Hackenberger\, Angew. Chem. Int. Ed. 2015\, 54\, 1950-1953.
\n(4.) D. Schumacher\, J. Helma\, F.A. Mann\, G. Pichler \, F. Natale\, E. Krause\, M.C. Cardoso\, C.P.R. Hackenberger\, H. Leonhar dt\, Angew. Chem. Int. Ed. 2015\, 54\, 13787-13791.
DTSTART;TZID=Europe/Stockholm:20160218T150000 DTEND;TZID=Europe/Stockholm:20160218T160000 SUMMARY:Seminar - Christian P.R. Hackenberger: New chemoselective reactions for the site-specific posttranslational modification and cellular deliver y of functional proteins URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 408-seminar-christian-p-r-hackenberger-new-chemoselective-reactions-for-th e-site-specific-posttranslational-modification-and-cellular-delivery-of-fu nctional-proteins.html X-ALT-DESC;FMTTYPE=TEXT/HTML:Department of Chemistry
Seminar
Speaker:
Professor Dr. Christian P. R. Hackenberger
Humboldt Universitä\;t zu Berlin
and
Leibniz
-Institut fü\;r Molekulare Pharmakologie (FMP)
Ti
tle:
New chemoselective reactions for the site-specifi
c posttranslational modification and cellular delivery of functional prote
ins
Place: Lilla hö\;rsalen\, KB3A9
Host: Christian Hedberg\, Department of Chemistry
Abstract:
Our lab constantly aims to identify
new bioorthogonal reactions for the synthesis and modification of function
al peptides and proteins. We apply these highly selective organic reaction
s to study functional consequences of naturally occurring posttranslationa
l protein modifications (PTMs) as well as to generate novel peptide- and p
rotein-conjugates for pharmaceutical and medicinal applications.(1)
In the second part of this presentation\, I
will focus on the cellular delivery of modified functional proteins. Ther
eby\, we employ cyclic cell penetrating peptides (cCPPs) to transport a fu
nctional full length protein to the cytosol of living cells as recently de
monstrated by the direct delivery of GFP-conjugates.(3) For protein modifi
cation we use a combined approach of intein expression\, bioorthogonal rea
ctions and recently developed enzymatic ligations\, called Tub-tag labelin
g.4 This concept is finally applied to generate site-specifically labelled
cell permeable nanobodies\, i.e. small antigen binding proteins that rema
in active within the reductive milieu inside living cells\, to interfere w
ith intracellular targets.
References
(1.) D. Schumacher\, C.P.R. Hackenberger\, Curr. Opin. Chem. Biol. 2014\,
22\, 62-69.
(2.) a)J. Bertran-Vicente\, R.A. Serwa\, M. Sch&u
uml\;mann\, P. Schmieder\, E. Krause\, C.P.R. Hackenberger\, J. Am Chem. S
oc. 2014\, 136\, 13622-13628\;
(b) J. Bertran-Vicente\, M. Penkert \, O. Nieto\, M. Schü\;mann\, P. Schmieder\, E. Krause\, C.P.R. Hacken berger\, submitted.
\n(3.) N. Nischan\, H.D. Herce\, F. Natale\, N. Bohlke\, N. Budisa\, M.C. Cardoso\, C.P.R. Hackenberger\, Angew. Chem. Int . Ed. 2015\, 54\, 1950-1953.
\n(4.) D. Schumacher\, J. Helma\, F.A. Mann\, G. Pichler\, F. Natale\, E. Krause\, M.C. Cardoso\, C.P.R. Hackenbe rger\, H. Leonhardt\, Angew. Chem. Int. Ed. 2015\, 54\, 13787-13791.
END:VEVENT BEGIN:VEVENT UID:20160304T141500UTC-6ee144@http://www.ucmr.umu.se/ DTSTAMP:20260604T234055Z CATEGORIES:Seminar DESCRIPTION:National and International Seminar Series 2016
\nSemin ar organised by MIMS
\nSpeaker:
\nIvo Boneca< br />Institute Pasteur\, Paris\, France
\nTitle: The peptido glycan as a signalling molecule in the host
\nHost: Felipe Cava
\nPlace: Betula Bldg 6M
\n\;
\nProf. Boneca re search aims at studying the role of bacterial peptidoglycan in host-microb e interactions. Using several bacterial models such as Helicobacter pylori \, Neisseria meningitidis\, Yersinia sp.\, and Listeria monocytogenes amon g others\, his lab explores the dynamics of peptidoglycan sensing in the h ost cell during infection and the way pathogens are able to subvert/modula te the host response by modifying their peptidoglycan.
\nMore inform
ation:
https://research.pasteur.fr/en/member/ivo-gomperts-boneca/
\;
\n\;
DTSTART;TZID=Europe/Stockholm:20160304T151500 DTEND;TZID=Europe/Stockholm:20160304T161500 SUMMARY:Nat. and Internat. Seminar Series - Ivo Boneca: The peptidoglycan a s a signalling molecule in the host URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 410-nat-and-internat-seminar-series-ivo-boneca-the-peptidoglycan-as-a-sign alling-molecule-in-the-host.html X-ALT-DESC;FMTTYPE=TEXT/HTML:National and International Seminar Series 2 016
\nSeminar organised by MIMS
\nSpeaker:
\nIvo
Boneca
Institute Pasteur\, Paris\, France
Title:
Host: Felipe Cava
\nPlace: Betula Bldg 6M
\n\;
\nProf. Boneca research aims at studying the role of bacterial peptidogly can in host-microbe interactions. Using several bacterial models such as H elicobacter pylori\, Neisseria meningitidis\, Yersinia sp.\, and Listeria monocytogenes among others\, his lab explores the dynamics of peptidoglyca n sensing in the host cell during infection and the way pathogens are able to subvert/modulate the host response by modifying their peptidoglycan.\n
More information:
https://research.pasteur.fr/en/member/ivo-gompert
s-boneca/
\;
\n\;
END:VEVENT BEGIN:VEVENT UID:20160311T140000UTC-0da7ec@http://www.ucmr.umu.se/ DTSTAMP:20260604T234055Z CATEGORIES:Seminar DESCRIPTION:National and International Seminar Series 2016
\nSpeak er:
\nMathias Hornef
\nInstitute for Medical Microbiology\, University Hospital\, RWTH Aachen\, Germany
\nTitle: Ontogeny of the intestinal host-microbial interaction
\nContact/host: Andrea Puhar\, MolBiol and MIMS
\nRoom: Betula\, bldg 6M\, NUS
\n\;
\nMore information:
\nhttp://www .ukaachen.de/en/clinics-institutes/institute-of-medical-microbiology/resea rch/hornef-group.html
\nhttps://scholar.google.se/scholar?q=mathias+ hornef&\;btnG=&\;hl=en&\;as_sdt=0%2C5
\nhttp://www.ncbi.nlm .nih.gov/pubmed/?term=mathias+hornef
DTSTART;TZID=Europe/Stockholm:20160311T150000 DTEND;TZID=Europe/Stockholm:20160311T160000 SUMMARY:Nat and Internat Seminar - Mathias Hornef: Ontogeny of the intestin al host-microbial interaction URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 411-nat-and-internat-seminar-mathias-hornef-ontogeny-of-the-intestinal-hos t-microbial-interaction.html X-ALT-DESC;FMTTYPE=TEXT/HTML:National and International Seminar Series 2 016
\nSpeaker:
\nMathias Hornef
\nInsti tute for Medical Microbiology\, University Hospital\, RWTH Aachen\, German y
\nTitle: Ontogeny of the intestinal host-microbial interac tion
\nContact/host: Andrea Puhar\, MolBiol and MIMS
\n< p>Room: Betula\, bldg 6M\, NUS\n\;
\nMore information:\n
http://www.ukaachen.de/en/clinics-institutes/institute-of-medical-m icrobiology/research/hornef-group.html
\nhttps://scholar.google.se/s cholar?q=mathias+hornef&\;btnG=&\;hl=en&\;as_sdt=0%2C5
\nht tp://www.ncbi.nlm.nih.gov/pubmed/?term=mathias+hornef
END:VEVENT BEGIN:VEVENT UID:20160315T141500UTC-95b0bc@http://www.ucmr.umu.se/ DTSTAMP:20260604T234055Z CATEGORIES:Seminar DESCRIPTION:Department of Medical Biochemistry and Biophysics Seminar Se ries
\nSpeaker:
Andrea Puhar
Group leader
MIMS
Title:
Regulation of extracellular ATP-depen
dent inflammation in the gut
Host: Anna Arnqvist
Place: Lilla hö\;rsalen\, KBC
Department of Medical Biochemistry and Biop hysics Seminar Series
\nSpeaker:
Andrea Puhar<
br />Group leader MIMS
Title:
Regulation of extrac
ellular ATP-dependent inflammation in the gut
Host: An
na Arnqvist
Place: Lilla hö\;rsalen\, KBC
MIMS Seminar - Department of Molecular Biology
\nSpeak
er:
Tanel Tenson
Title:
\nTran sfer routes of antibiotic resistance
\nHost: Vasili Hauryli uk\, MIMS
\nPlace: Major Groove\, Bldg 6M\, NUS
\n
Antibi
otics are some of the most influential innovations of medicine. However\,
the spread of resistance is a considerable threat that might take us back
to the pre-antibiotic era. The problem is perceived as medical\, although
more than half of the amount of antibiotics produced is consumed in animal
husbandry where resistance can also easily emerge.
The resistance can spread through food products\, waste water systems\, agricultural pra ctices etc. Isolated transfer events have been characterised that outline these transfer routes\, but we lack a quantitative knowledge about the ext ent and importance of the different segments.
\nTherefore\, we have analyzed resistant bacteria critical for medicine in Southern Estonia\, wi th emphasis on the settings around Tartu. The strains were collected from human samples\, animal husbandry\, ground waters\, sewage and characterize d by measuring antibiotic sensitivity patterns and whole genome sequencing . The results suggest transfer routes between the different segments under study.
\n\;
\n\;
DTSTART;TZID=Europe/Stockholm:20160330T100000 DTEND;TZID=Europe/Stockholm:20160330T110000 SUMMARY:Seminar - Tanel Tenson: Transfer routes of antibiotic resistance URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 412-seminar-tanel-tenson-transfer-routes-of-antibiotic-resistance.html X-ALT-DESC;FMTTYPE=TEXT/HTML:MIMS Seminar - Department of Molecular Biol ogy
\nSpeaker:
Tanel Tenson
Title:
\nTransfer routes of antibiotic resistance
\nHos t: Vasili Hauryliuk\, MIMS
\nPlace: Major Groove\, Bldg 6M\, NUS
\n
Antibiotics are some of the most influential innovations of med
icine. However\, the spread of resistance is a considerable threat that mi
ght take us back to the pre-antibiotic era. The problem is perceived as me
dical\, although more than half of the amount of antibiotics produced is c
onsumed in animal husbandry where resistance can also easily emerge.
The resistance can spread through food products\, waste water systems\, agricultural practices etc. Isolated transfer events have been characteri sed that outline these transfer routes\, but we lack a quantitative knowle dge about the extent and importance of the different segments.
\nThe refore\, we have analyzed resistant bacteria critical for medicine in Sout hern Estonia\, with emphasis on the settings around Tartu. The strains wer e collected from human samples\, animal husbandry\, ground waters\, sewage and characterized by measuring antibiotic sensitivity patterns and whole genome sequencing. The results suggest transfer routes between the differe nt segments under study.
\n\;
\n\;
END:VEVENT BEGIN:VEVENT UID:20160415T110000UTC-99d8c8@http://www.ucmr.umu.se/ DTSTAMP:20260604T234055Z CATEGORIES:Seminar DESCRIPTION:Speaker:
Anna Bettencourt
University of Lisbon\, P
rotugal
Title:
'Antibiotic delivery platforms for tar
geting bone infections'
Room: Seminar room of the Departm
ent of Clinical Microbiology. BYGGNAD 6B\, room 23
Department of Bact
eriology /Department of Micobiology
The entrance is 50m left of blood
center\, two stairs up and take left. Ring the bell at Microbiology
\;
\nInformation from Madelei ne:
\nMadeleine Ramstedt has two guests here in Umeå\; next wee
k that are from Lisbon in Portugal and that do research on how to prevent
biofilm formation on medical devices using different approaches. I know th
em from a European network (www.ipromedai.net) working to find strategies
for preventing infection of medical devices (including dental ones). They
are here to see how we do our biofilm experiments in flow chambers. \
;
\;
Here are links to their web pages:
\;
h
ttp://imed.ulisboa.pt/cv/isabel-alexandra-caldeira-ribeiro/
\;http://imed.ulisboa.pt/cv/ana-francisca-de-campos-simao-bettencourt/ \;
They will give a ~20 min presentation each on Friday 15th
April starting at 13 in the afternoon and we will have some time also for
questions and discussions. I expect the whole thing will take about an ho
ur. We will be in the seminar room at Clinical microbiology. The titles fo
r the talks will be:
\;
'Antibiotic delivery platforms for
targeting bone infections' (Ana F. Bettencourt)
\;
'Sophoro
lipids: The Yeast Synthesised Glycolipids with Diverse Biological Activiti
es' (Isabel A.C. Ribeiro)
\;
I hope you would like to join
us and listen to these guests.
If you have a colleague that you think
may be interested please also forward this e-mail to them.
Everyone
is very welcome to join the talks.
Speaker:
Anna Bettencourt
Univers
ity of Lisbon\, Protugal
Title:
'Antibiotic delivery
platforms for targeting bone infections'
Room: Seminar ro
om of the Department of Clinical Microbiology. BYGGNAD 6B\, room 23
D
epartment of Bacteriology /Department of Micobiology
The entrance is
50m left of bloodcenter\, two stairs up and take left. Ring the bell at Mi
crobiology
Host Madeleine Ramstedt
\n\;
\nInforma tion from Madeleine:
\nMadeleine Ramstedt has two guests here in Ume
å\; next week that are from Lisbon in Portugal and that do research o
n how to prevent biofilm formation on medical devices using different appr
oaches. I know them from a European network (www.ipromedai.net) working to
find strategies for preventing infection of medical devices (including de
ntal ones). They are here to see how we do our biofilm experiments in flow
chambers. \;
\;
Here are links to their web pages:
\;
http://imed.ulisboa.pt/cv/isabel-alexandra-caldeira-ribeir
o/
\;
http://imed.ulisboa.pt/cv/ana-francisca-de-campos-sim
ao-bettencourt/
\;
They will give a ~20 min presentation ea
ch on Friday 15th April starting at 13 in the afternoon and we will have s
ome time also for questions and discussions. I expect the whole thing will
take about an hour. We will be in the seminar room at Clinical microbiolo
gy. The titles for the talks will be:
\;
'Antibiotic delive
ry platforms for targeting bone infections' (Ana F. Bettencourt)
&nbs
p\;
'Sophorolipids: The Yeast Synthesised Glycolipids with Diverse Bi
ological Activities' (Isabel A.C. Ribeiro)
\;
I hope you wo
uld like to join us and listen to these guests.
If you have a colleag
ue that you think may be interested please also forward this e-mail to the
m.
Everyone is very welcome to join the talks.
Speaker:
Isabel A.C. Ribeiro
Univ
ersity of Lisbon\, Protugal
Title:
'Sophorolipids: Th
e Yeast Synthesised Glycolipids with Diverse Biological Activities'
Room: Seminar room of the Department of Clinical Microbiology\n
Host Madeleine Ramstedt
\n\;
\nInformation from Ma deleine:
\nMadeleine Ramstedt has two guests here in Umeå\; nex
t week that are from Lisbon in Portugal and that do research on how to pre
vent biofilm formation on medical devices using different approaches. I kn
ow them from a European network (www.ipromedai.net) working to find strate
gies for preventing infection of medical devices (including dental ones).
They are here to see how we do our biofilm experiments in flow chambers. &
nbsp\;
\;
Here are links to their web pages:
\;http://imed.ulisboa.pt/cv/isabel-alexandra-caldeira-ribeiro/
&nbs
p\;
http://imed.ulisboa.pt/cv/ana-francisca-de-campos-simao-bettencou
rt/
\;
They will give a ~20 min presentation each on Friday
15th April starting at 13 in the afternoon and we will have some time als
o for questions and discussions. I expect the whole thing will take about
an hour. We will be in the seminar room at Clinical microbiology. The titl
es for the talks will be:
\;
'Antibiotic delivery platforms
for targeting bone infections' (Ana F. Bettencourt)
\;
'So
phorolipids: The Yeast Synthesised Glycolipids with Diverse Biological Act
ivities' (Isabel A.C. Ribeiro)
\;
I hope you would like to
join us and listen to these guests.
If you have a colleague that you
think may be interested please also forward this e-mail to them.
Ever
yone is very welcome to join the talks.
Speaker:
Isabel A.C. Ribeiro
University of Lisbon\, Protugal
Title:
'
Sophorolipids: The Yeast Synthesised Glycolipids with Diverse Biological A
ctivities'
Room: Seminar room of the Department of Clinic al Microbiology
\nHost Madeleine Ramstedt
\n\;
\nIn formation from Madeleine:
\nMadeleine Ramstedt has two guests here i
n Umeå\; next week that are from Lisbon in Portugal and that do resea
rch on how to prevent biofilm formation on medical devices using different
approaches. I know them from a European network (www.ipromedai.net) worki
ng to find strategies for preventing infection of medical devices (includi
ng dental ones). They are here to see how we do our biofilm experiments in
flow chambers. \;
\;
Here are links to their web page
s:
\;
http://imed.ulisboa.pt/cv/isabel-alexandra-caldeira-r
ibeiro/
\;
http://imed.ulisboa.pt/cv/ana-francisca-de-campo
s-simao-bettencourt/
\;
They will give a ~20 min presentati
on each on Friday 15th April starting at 13 in the afternoon and we will h
ave some time also for questions and discussions. I expect the whole thing
will take about an hour. We will be in the seminar room at Clinical micro
biology. The titles for the talks will be:
\;
'Antibiotic d
elivery platforms for targeting bone infections' (Ana F. Bettencourt)
\;
'Sophorolipids: The Yeast Synthesised Glycolipids with Diver
se Biological Activities' (Isabel A.C. Ribeiro)
\;
I hope y
ou would like to join us and listen to these guests.
If you have a co
lleague that you think may be interested please also forward this e-mail t
o them.
Everyone is very welcome to join the talks.
National and International Seminar Series 2016
\nSpeak er:
\nJ. Andrew Alspaugh
Duke University\, Dep
artment of Medicine\, USA
Title:
Hidden in plain sigh
t: Avoidance of immunerecognition by pathogenic fungi
Hos t Constantin Urban\, Clinical Microbiology
\nRoom: Betula Bldg 6M
DTSTART;TZID=Europe/Stockholm:20160422T150000 DTEND;TZID=Europe/Stockholm:20160422T160000 SUMMARY:Nat. and Internat. Seminar Series - J. Andrew Alspaugh: Hidden in plain sight: Avoidance of immunerecognition by pathogenic fungi URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 416-nat-and-internat-seminar-series-j-andrew-alspaugh-hidden-in-plain-sigh t-avoidance-of-immunerecognition-by-pathogenic-fungi.html X-ALT-DESC;FMTTYPE=TEXT/HTML:National and International Seminar Series 2 016
\nSpeaker:
\nJ. Andrew Alspaugh
Duke
University\, Department of Medicine\, USA
Title:
Hid
den in plain sight: Avoidance of immunerecognition by pathogenic fungi
Host Constantin Urban\, Clinical Microbiology
\nRoom: Betula Bldg 6M
END:VEVENT BEGIN:VEVENT UID:20160512T130000UTC-69fb21@http://www.ucmr.umu.se/ DTSTAMP:20260604T234055Z CATEGORIES:Seminar DESCRIPTION:UCMR-MIMS Seminar
\nSpeaker:
Jay C. D. Hi
nton
Institute of Integrative Biology\, University of Liverp
ool\, UK\,
Title:
Understanding the choreography of S
almonella transcription with RNA-seq
Place: Thymine\,
Department of Molecular Biology\, 2nd floor
http://www.umu.se/english/about-um
u/campus-maps?id=480
Host: Bernt Eric Uhlin &\; Mikael Rhen
\nAbstract:
\nBacterial transcriptional netw orks typically consist of hundreds of transcription factors and thousands of promoters. However\, the true complexity of transcription in a bacteria l pathogen remains to be established. We devised a suite of 22 different e nvironmental conditions that reflect the pathogenic lifestyle of Salmo nella enterica serovar Typhimurium strain 4/74 during infection of a host\, and used RNA-seq to generate a compendium of Salmonella gene expres sion. Individual in vitro conditions stimulated characteristic tr anscriptional signatures\, and the suite of 22 conditions induced expressi on of 86% of all S. typhimurium genes 1. Recently\, we compared t hese in vitro conditions with the intra-macrophage gene expressio n profiles of S. typhimurium 2. \;All the data can be access ed at http://tinyurl.com/SalComMac< /a>. We hope that this database of environmentally-controlled expression o f every transcriptional feature of S. typhimurium will be a usefu l resource for the bacterial research community\, and the results explain the environmental signals that stimulate S. typhimurium promoters during infection.
\nWe found that the transcription of the majority of the 3825 S. typhimurium promoters is environmentally-responsi ve. Our global approach has identified 280 small RNAs in S. typhimuriu m\; these sRNAs were analysed in the context of chromosome localisati on and Hfq-association.
\nI will discuss the environmental condition s that stimulate expression of the Salmonella pathogenicity islands\, will present a comprehensive expression landscape of sRNAs and discuss our app roach for defining the relative strength of S. typhimurium promot ers during macrophage infection.
\nE-mail: This email address is being protected from spambot s. You need JavaScript enabled to view it.
\n\;
\nReferences
\n1 Srikumar S\, Kr ö\;ger C\, Hé\;brard M\, Colgan A\, Owen SV\, Sivasankaran SK\, Cameron ADS\, Hokamp K\, Hinton JCD: RNA-seq Brings New Insights to the In tra-Macrophage Transcriptome of Salmonella Typhimurium. PLOS Pathogens 201 5\, 11:e1005262.
\n2 Krö\;ger C\, Colgan A\, Srikumar S\, Handle r K\, Sivasankaran SK\, Hammarlof DL\, Canals R\, Grissom JE\, Conway T\, Hokamp K\, Hinton JC: An infection-relevant transcriptomic compendium for Salmonella enterica Serovar Typhimurium. Cell Host Microbe 2013\, 14:683-6 95.
DTSTART;TZID=Europe/Stockholm:20160512T150000 DTEND;TZID=Europe/Stockholm:20160512T160000 SUMMARY:Seminar - Jay C.D. Hinton: Understanding the choreography of Salmon ella transcription with RNA-seq URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 417-seminar-jay-c-d-hinton-understanding-the-choreography-of-salmonella-tr anscription-with-rna-seq.html X-ALT-DESC;FMTTYPE=TEXT/HTML:UCMR-MIMS Seminar
\nSpeaker:
Institute of Integrative Biology\, Uni
versity of Liverpool\, UK\,
Title:
Understanding the
choreography of Salmonella transcription with RNA-seq
Place: Thymine\, Department of Molecular Biology\, 2nd floor
http://www.umu.se
/english/about-umu/campus-maps?id=480
Host: Bernt Eric Uhlin & amp\; Mikael Rhen
\nAbstract:
\nBacterial tra nscriptional networks typically consist of hundreds of transcription facto rs and thousands of promoters. However\, the true complexity of transcript ion in a bacterial pathogen remains to be established. We devised a suite of 22 different environmental conditions that reflect the pathogenic lifes tyle of Salmonella enterica serovar Typhimurium strain 4/74 durin g infection of a host\, and used RNA-seq to generate a compendium of Salmo nella gene expression. Individual in vitro conditions stimulated characteristic transcriptional signatures\, and the suite of 22 conditions induced expression of 86% of all S. typhimurium genes 1. Recentl y\, we compared these in vitro conditions with the intra-macropha ge gene expression profiles of S. typhimurium 2. \;All the d ata can be accessed at http://tinyu rl.com/SalComMac. We hope that this database of environmentally-contro lled expression of every transcriptional feature of S. typhimurium will be a useful resource for the bacterial research community\, and the results explain the environmental signals that stimulate S. typhimuri um promoters during infection.
\nWe found that the transcriptio n of the majority of the 3825 S. typhimurium promoters is environ mentally-responsive. Our global approach has identified 280 small RNAs in S. typhimurium\; these sRNAs were analysed in the context of chro mosome localisation and Hfq-association.
\nI will discuss the enviro nmental conditions that stimulate expression of the Salmonella pathogenici ty islands\, will present a comprehensive expression landscape of sRNAs an d discuss our approach for defining the relative strength of S. typhim urium promoters during macrophage infection.
\nE-mail: This email address is being prote cted from spambots. You need JavaScript enabled to view it.
\n\;
\nReferences
\n1 Srikumar S\, Krö\;ger C\, Hé\;brard M\, Colgan A\, Owen SV\, S ivasankaran SK\, Cameron ADS\, Hokamp K\, Hinton JCD: RNA-seq Brings New I nsights to the Intra-Macrophage Transcriptome of Salmonella Typhimurium. P LOS Pathogens 2015\, 11:e1005262.
\n2 Krö\;ger C\, Colgan A\, Sr ikumar S\, Handler K\, Sivasankaran SK\, Hammarlof DL\, Canals R\, Grissom JE\, Conway T\, Hokamp K\, Hinton JC: An infection-relevant transcriptomi c compendium for Salmonella enterica Serovar Typhimurium. Cell Host Microb e 2013\, 14:683-695.
END:VEVENT END:VCALENDAR