BEGIN:VCALENDAR VERSION:2.0 PRODID:-//http://www.ucmr.umu.se//NONSGML kigkonsult.se iCalcreator 2.29.29 // CALSCALE:GREGORIAN METHOD:PUBLISH UID:3440b5f4-9531-42d9-b099-506317a3805e X-WR-CALNAME:JCal Pro Calendar X-WR-CALDESC:Your online events calendar X-WR-TIMEZONE:Europe/Stockholm BEGIN:VTIMEZONE TZID:Europe/Stockholm BEGIN:STANDARD TZNAME:CET DTSTART:20231029T030000 TZOFFSETFROM:+0200 TZOFFSETTO:+0100 RDATE:20241027T030000 END:STANDARD BEGIN:DAYLIGHT TZNAME:CEST DTSTART:20240331T020000 TZOFFSETFROM:+0100 TZOFFSETTO:+0200 RDATE:20250330T020000 END:DAYLIGHT END:VTIMEZONE BEGIN:VEVENT UID:20190510T120000UTC-7ff3ce@http://www.ucmr.umu.se/ DTSTAMP:20240329T151355Z CATEGORIES:Seminar DESCRIPTION:
Note Room Change!
\nNational and International Seminar Series Spr ing 2019
\nSpeaker:
Lukas Kenner
Ludwig Boltzmann Inst for Cancer Research\, Vienna\, Austria
Titl
e:
Genetics\, transcriptional factors and models in preclinic
al studies of prostate cancer
Host: Jenny Persson
\nRoom: Major Groove\, Bldg 6L\, NUS
\nCoffee/te a/cookies served 30 min before start
\nPlease contact respe
ctive host for enquiries to meet with speaker
General questions regar
ding the seminar series\; please contact This email address is being protected from spambots. You n
eed JavaScript enabled to view it. or This emai
l address is being protected from spambots. You need JavaScript enabled to
view it. \;  \; \
;
Note Room Change!
\nNational and International S eminar Series Spring 2019
\nSpeaker:
Lukas Ken
ner
Ludwig Boltzmann Inst for Cancer Research\, Vienna\, Aus
tria
Title:
Genetics\, transcriptional factors and mo
dels in preclinical studies of prostate cancer
Host: Jenn y Persson
\nRoom: Major Groove\, Bldg 6L\, NUS
\nCoffee/tea/cookies served 30 min before start
\nPl
ease contact respective host for enquiries to meet with speaker
Gener
al questions regarding the seminar series\; please contact This email address is being protected fr
om spambots. You need JavaScript enabled to view it. or This email address is being protected from spambots. You need Jav
aScript enabled to view it.&nb
sp\;  \; \;
NOTE ROOM CHANGE!
\nNational and International Seminar Series Spring 2019
\nSpeaker:
Derek Doherty
Trinity College
\, Dublin\, Ireland
Title:
Targeting CD1d for cancer
immunotherapy
Host: Johan Normark
\nPlace: Major Groove\, Dept of Molecular Biology\, bldg 6L NUS
\nCoffee/tea/cookies served 30 min b efore start
\nPlease contact respective host for enquiries
to meet with speaker
General questions regarding the seminar series\;
please contact This emai
l address is being protected from spambots. You need JavaScript enabled to
view it. or This email address is being protec
ted from spambots. You need JavaScript enabled to view it. \;  \; \;
NOTE ROOM CHANGE!
\nNational and International Seminar S eries Spring 2019
\nSpeaker:
Derek Doherty
Trinity College\, Dublin\, Ireland
Title:
Targeting
CD1d for cancer immunotherapy
Host: Johan Normark
\n< p>Place: Major Groove\, Dept of Mol ecular Biology\, bldg 6L NUS\nCoffee/tea/cookie s served 30 min before start
\nPlease contact respective ho
st for enquiries to meet with speaker
General questions regarding the
seminar series\; please contact This email address is being protected from spambots. You need Java
Script enabled to view it. \;  \; \;
p>
END:VEVENT
BEGIN:VEVENT
UID:20190524T120000UTC-6be1b2@http://www.ucmr.umu.se/
DTSTAMP:20240329T151355Z
CATEGORIES:Seminar
DESCRIPTION:
NOTE ROOM CHANGE!
\nNational and International Seminar Series Spring 2019
\nSpeaker:
Oriol Gallego
Pompeu Fabra\,
Barcelona\, Spain
Title:
Towards the elusive mechani
sm of exocytosis: doing structural biology in living cells
Host: Franscesca Aguiló
\nRoom: Major Groove\, Dept of Molecular Biology\, Bldg 6L\, NUS
\nCoffee/tea/cookies served 30 min before start
\n< p>Please contact respective host for enquiries to meet with speakerNOTE ROOM CHANGE!
\nNational and International Seminar S eries Spring 2019
\nSpeaker:
Oriol Gallego
Pompeu Fabra\, Barcelona\, Spain
Title:
Towards th
e elusive mechanism of exocytosis: doing structural biology in living cell
s
Host: Franscesca Aguiló
\nRoom: Major Groove\, Dept of Molecular Biology\, Bldg 6L\ , NUS
\nCoffee/tea/cookies served 30 min before start
\nPlease contact respective host for enquiries to mee
t with speaker
General questions regarding the seminar series\; pleas
e contact This email addr
ess is being protected from spambots. You need JavaScript enabled to view
it. or This email address is being prote
cted from spambots. You need JavaScript enabled to view it. \;  \; \;
Department of Molecular Biology/MIMS
Extra Seminar
Speaker:
Himanshu Sharma
Indian Institute
of Technology Guwahati\, Assam\, India
Title:
Ribosom
e assembly defects abrogate initiation factor mediated inspection of start
codon
Host:
Jonas Barandun\, MIMS group leader and
SciLifeLab National Fellow\, Department of Molecular Biology
Room: Thymine\, Dept Molecular Biology\, NUS\, bldg 6K/L 2 stairs up
\nAbstract:
Faithful protein synthesis is ensured by ext
ensive quality control checkpoints using components of the translational m
achinery. However\, the implications of defective ribosome assembly on pro
tein synthesis and the associated translation quality control mechanisms i
n bacteria remain grossly unaddressed. In this study\, using E. coli as a
model organism we show that premature ribosomes evade scrutiny of cognate
start Codon by initiation factors during translation initiation. Resultant
ly the defective ribosomes make way into the translation cycle with severe
ly compromised decoding and protein synthesis capabilities. The enfeebled
binding of premature ribosomes to initiation factors also licenses the rap
id conversion of the 30S (pre) initiation complex to 70S initiation comple
x. Overall\, our work highlights that a mass balance deficit between prema
ture ribosomes and initiation factors steers the entry of premature riboso
mes into the translation cycle.
(Co-Author: B. Anand)
Department of Molecular Biology/MIMS
E
xtra Seminar
Speaker:
Himanshu Sharma
I
ndian Institute of Technology Guwahati\, Assam\, India
Title:
Ribosome assembly defects abrogate initiation factor mediated ins
pection of start codon
Host:
Jonas Barandun\, MIMS g
roup leader and SciLifeLab National Fellow\, Department of Molecular Biolo
gy
Room: Thymine\, Dept Molecular Biology\, NUS\, bldg 6K/L 2 stai rs up
\nAbstract:
Faithful protein synthesis i
s ensured by extensive quality control checkpoints using components of the
translational machinery. However\, the implications of defective ribosome
assembly on protein synthesis and the associated translation quality cont
rol mechanisms in bacteria remain grossly unaddressed. In this study\, usi
ng E. coli as a model organism we show that premature ribosomes evade scru
tiny of cognate start Codon by initiation factors during translation initi
ation. Resultantly the defective ribosomes make way into the translation c
ycle with severely compromised decoding and protein synthesis capabilities
. The enfeebled binding of premature ribosomes to initiation factors also
licenses the rapid conversion of the 30S (pre) initiation complex to 70S i
nitiation complex. Overall\, our work highlights that a mass balance defic
it between premature ribosomes and initiation factors steers the entry of
premature ribosomes into the translation cycle.
(Co-Author: B. Anand)
Department of Molecular Biology/MIMS
E
xtra Seminar
Magnus Ölander
Department of Ph
armacy\, Uppsala University
Title:
Proteomic and functio
nal analysis of
in vitro systems for studi
es of drug disposition in the human small intestine and liver
Place: Thymine\, Molecular Biology bldg. 6K/L (2 stairs up)
Host: Barbara Sixt\, MIMS group leader\, \; Dept of Molecular Bio logy
\n \;
DTSTART;TZID=Europe/Stockholm:20190529T133000 DTEND;TZID=Europe/Stockholm:20190529T143000 SUMMARY:Proteomic and functional analysis of in vitro systems for studies o f drug disposition in the human small intestine and liver URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/ 579-proteomic-and-functional-analysis-of-in-vitro-systems-for-studies-of-d rug-disposition-in-the-human-small-intestine-and-liver.html X-ALT-DESC;FMTTYPE=TEXT/HTML:Department of Molecular Biology/MIM
S
Extra Seminar
Magnus Ölander
Department of Pharmacy\, Uppsala University
Title:
Prot
eomic and functional analysis of
in vitro
systems for studies of drug disposition in the human small intestine and l
iver
Place: Thymine\, Molecular Biology bldg. 6K/L
(2 stairs up)
Host: Barbara Sixt\, MIMS group leader\, \; Dept of Molecular Biology
\n \;
END:VEVENT END:VCALENDAR