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BEGIN:VEVENT
UID:20160204T080000UTC-619a37@http://www.ucmr.umu.se/
DTSTAMP:20260514T233935Z
CATEGORIES:Events
DESCRIPTION:<p>Department of Molecular Biology and MIMS</p>\n<p>Thesis Defe
 nce<br /><strong>Christopher Andersson</strong></p>\n<p><strong>Regulatory
  pathways and virulence inhibition in Listeria monocytogenes</strong><br /
 ><br />Supervisor: J&ouml\;rgen Johansson</p>\n<p>Faculty Examiner:<br />P
 rofessor Claude Parsot\, Unite de Pathogenie Microbienne Moleculaire\, Ins
 titute Pasteur\, Paris</p>\n<p>&nbsp\;</p>\n<p>Place: KB3B1\, Stora h&ouml
 \;rsalen\, KBC-Building</p>
DTSTART;TZID=Europe/Stockholm:20160204T090000
DTEND;TZID=Europe/Stockholm:20160204T120000
SUMMARY:Thesis Defence - Christopher Andersson
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/163-events/4
 05-thesis-defence-christopher-andersson.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:<p>Department of Molecular Biology and MIMS</p
 >\n<p>Thesis Defence<br /><strong>Christopher Andersson</strong></p>\n<p><
 strong>Regulatory pathways and virulence inhibition in Listeria monocytoge
 nes</strong><br /><br />Supervisor: J&ouml\;rgen Johansson</p>\n<p>Faculty
  Examiner:<br />Professor Claude Parsot\, Unite de Pathogenie Microbienne 
 Moleculaire\, Institute Pasteur\, Paris</p>\n<p>&nbsp\;</p>\n<p>Place: KB3
 B1\, Stora h&ouml\;rsalen\, KBC-Building</p>
END:VEVENT
BEGIN:VEVENT
UID:20160216T141500UTC-613d79@http://www.ucmr.umu.se/
DTSTAMP:20260514T233935Z
CATEGORIES:Seminar
DESCRIPTION:<p>MIMS- UCMR Seminar Medical Biochemistry and Biophysics Semin
 ar</p>\n<p>Speaker: <br /><strong>Oliver Billker</strong> <br />Wellcome T
 rust Sanger Institute\, Cambridge\, United Kingdom.</p>\n<p>Title: <br /><
 strong>'Regulating a complex life cycle &mdash\; New molecular tools revea
 l mechanisms of malaria parasite transmission by mosquitoes'.</strong></p>
 \n<p>Host: Bernt Eric Uhlin</p>\n<p>&nbsp\;</p>\n<p>Place: Lilla h&ouml\;r
 salen KB3A9\, KBC</p>
DTSTART;TZID=Europe/Stockholm:20160216T151500
DTEND;TZID=Europe/Stockholm:20160216T161500
SUMMARY:Seminar - Oliver Billker: Regulating a complex life cycle — New mol
 ecular tools reveal mechanisms of malaria parasite transmission by mosquit
 oes
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/
 407-seminar-oliver-billker-regulating-a-complex-life-cycle-new-molecular-t
 ools-reveal-mechanisms-of-malaria-parasite-transmission-by-mosquitoes.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:<p>MIMS- UCMR Seminar Medical Biochemistry and
  Biophysics Seminar</p>\n<p>Speaker: <br /><strong>Oliver Billker</strong>
  <br />Wellcome Trust Sanger Institute\, Cambridge\, United Kingdom.</p>\n
 <p>Title: <br /><strong>'Regulating a complex life cycle &mdash\; New mole
 cular tools reveal mechanisms of malaria parasite transmission by mosquito
 es'.</strong></p>\n<p>Host: Bernt Eric Uhlin</p>\n<p>&nbsp\;</p>\n<p>Place
 : Lilla h&ouml\;rsalen KB3A9\, KBC</p>
END:VEVENT
BEGIN:VEVENT
UID:20160218T140000UTC-3ac68c@http://www.ucmr.umu.se/
DTSTAMP:20260514T233935Z
CATEGORIES:Seminar
DESCRIPTION:<p>Department of Chemistry<br /> Seminar<br /> Speaker:<br /> <
 span><strong>Professor Dr. Christian P. R. Hackenberger</strong><br /> Hum
 boldt Universit&auml\;t zu Berlin<br /> and<br /> Leibniz-Institut f&uuml\
 ;r Molekulare Pharmakologie (FMP) </span><br /> <br /> Title:<br /> <stron
 g><span>New chemoselective reactions for the site-specific posttranslation
 al modification and cellular delivery of functional proteins</span></stron
 g><br /> <br /> Place: Lilla h&ouml\;rsalen\, KB3A9<br /> <br /> Host: Chr
 istian Hedberg\, Department of Chemistry<br /> <br /> <br /> <strong>Abstr
 act: </strong><br /> Our lab constantly aims to identify new bioorthogonal
  reactions for the synthesis and modification of functional peptides and p
 roteins. We apply these highly selective organic reactions to study functi
 onal consequences of naturally occurring posttranslational protein modific
 ations (PTMs) as well as to generate novel peptide- and protein-conjugates
  for pharmaceutical and medicinal applications.(1)</p>\n<p>In the first pa
 rt of this lecture\, our recent efforts in the synthesis and analysis of n
 aturally occurring labile PTMs including the synthesis of site-specificall
 y phosphorylated Lys-peptides (pLys) using the Staudinger-phosphite reacti
 on (2a) as well as phosphorylated Cys-peptides (pCys)\, (2b) will be prese
 nted.</p>\n<p>In the second part of this presentation\, I will focus on th
 e cellular delivery of modified functional proteins. Thereby\, we employ c
 yclic cell penetrating peptides (cCPPs) to transport a functional full len
 gth protein to the cytosol of living cells as recently demonstrated by the
  direct delivery of GFP-conjugates.(3) For protein modification we use a c
 ombined approach of intein expression\, bioorthogonal reactions and recent
 ly developed enzymatic ligations\, called Tub-tag labeling.4 This concept 
 is finally applied to generate site-specifically labelled cell permeable n
 anobodies\, i.e. small antigen binding proteins that remain active within 
 the reductive milieu inside living cells\, to interfere with intracellular
  targets.<br /> <br /> <strong>References</strong><br /> (1.) D. Schumache
 r\, C.P.R. Hackenberger\, Curr. Opin. Chem. Biol. 2014\, 22\, 62-69.<br />
  <br /> (2.) a)J. Bertran-Vicente\, R.A. Serwa\, M. Sch&uuml\;mann\, P. Sc
 hmieder\, E. Krause\, C.P.R. Hackenberger\, J. Am Chem. Soc. 2014\, 136\, 
 13622-13628\;</p>\n<p>(b) J. Bertran-Vicente\, M. Penkert\, O. Nieto\, M. 
 Sch&uuml\;mann\, P. Schmieder\, E. Krause\, C.P.R. Hackenberger\, submitte
 d.</p>\n<p>(3.) N. Nischan\, H.D. Herce\, F. Natale\, N. Bohlke\, N. Budis
 a\, M.C. Cardoso\, C.P.R. Hackenberger\, Angew. Chem. Int. Ed. 2015\, 54\,
  1950-1953.</p>\n<p>(4.) D. Schumacher\, J. Helma\, F.A. Mann\, G. Pichler
 \, F. Natale\, E. Krause\, M.C. Cardoso\, C.P.R. Hackenberger\, H. Leonhar
 dt\, Angew. Chem. Int. Ed. 2015\, 54\, 13787-13791.</p>
DTSTART;TZID=Europe/Stockholm:20160218T150000
DTEND;TZID=Europe/Stockholm:20160218T160000
SUMMARY:Seminar - Christian P.R. Hackenberger: New chemoselective reactions
  for the site-specific posttranslational modification and cellular deliver
 y of functional proteins
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/164-seminar/
 408-seminar-christian-p-r-hackenberger-new-chemoselective-reactions-for-th
 e-site-specific-posttranslational-modification-and-cellular-delivery-of-fu
 nctional-proteins.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:<p>Department of Chemistry<br /> Seminar<br />
  Speaker:<br /> <span><strong>Professor Dr. Christian P. R. Hackenberger</
 strong><br /> Humboldt Universit&auml\;t zu Berlin<br /> and<br /> Leibniz
 -Institut f&uuml\;r Molekulare Pharmakologie (FMP) </span><br /> <br /> Ti
 tle:<br /> <strong><span>New chemoselective reactions for the site-specifi
 c posttranslational modification and cellular delivery of functional prote
 ins</span></strong><br /> <br /> Place: Lilla h&ouml\;rsalen\, KB3A9<br />
  <br /> Host: Christian Hedberg\, Department of Chemistry<br /> <br /> <br
  /> <strong>Abstract: </strong><br /> Our lab constantly aims to identify 
 new bioorthogonal reactions for the synthesis and modification of function
 al peptides and proteins. We apply these highly selective organic reaction
 s to study functional consequences of naturally occurring posttranslationa
 l protein modifications (PTMs) as well as to generate novel peptide- and p
 rotein-conjugates for pharmaceutical and medicinal applications.(1)</p>\n<
 p>In the first part of this lecture\, our recent efforts in the synthesis 
 and analysis of naturally occurring labile PTMs including the synthesis of
  site-specifically phosphorylated Lys-peptides (pLys) using the Staudinger
 -phosphite reaction (2a) as well as phosphorylated Cys-peptides (pCys)\, (
 2b) will be presented.</p>\n<p>In the second part of this presentation\, I
  will focus on the cellular delivery of modified functional proteins. Ther
 eby\, we employ cyclic cell penetrating peptides (cCPPs) to transport a fu
 nctional full length protein to the cytosol of living cells as recently de
 monstrated by the direct delivery of GFP-conjugates.(3) For protein modifi
 cation we use a combined approach of intein expression\, bioorthogonal rea
 ctions and recently developed enzymatic ligations\, called Tub-tag labelin
 g.4 This concept is finally applied to generate site-specifically labelled
  cell permeable nanobodies\, i.e. small antigen binding proteins that rema
 in active within the reductive milieu inside living cells\, to interfere w
 ith intracellular targets.<br /> <br /> <strong>References</strong><br /> 
 (1.) D. Schumacher\, C.P.R. Hackenberger\, Curr. Opin. Chem. Biol. 2014\, 
 22\, 62-69.<br /> <br /> (2.) a)J. Bertran-Vicente\, R.A. Serwa\, M. Sch&u
 uml\;mann\, P. Schmieder\, E. Krause\, C.P.R. Hackenberger\, J. Am Chem. S
 oc. 2014\, 136\, 13622-13628\;</p>\n<p>(b) J. Bertran-Vicente\, M. Penkert
 \, O. Nieto\, M. Sch&uuml\;mann\, P. Schmieder\, E. Krause\, C.P.R. Hacken
 berger\, submitted.</p>\n<p>(3.) N. Nischan\, H.D. Herce\, F. Natale\, N. 
 Bohlke\, N. Budisa\, M.C. Cardoso\, C.P.R. Hackenberger\, Angew. Chem. Int
 . Ed. 2015\, 54\, 1950-1953.</p>\n<p>(4.) D. Schumacher\, J. Helma\, F.A. 
 Mann\, G. Pichler\, F. Natale\, E. Krause\, M.C. Cardoso\, C.P.R. Hackenbe
 rger\, H. Leonhardt\, Angew. Chem. Int. Ed. 2015\, 54\, 13787-13791.</p>
END:VEVENT
BEGIN:VEVENT
UID:20160219T090000UTC-52516a@http://www.ucmr.umu.se/
DTSTAMP:20260514T233935Z
CATEGORIES:General
DESCRIPTION:<p>Department of Chemistry</p>\n<p>Thesis Defence<br /><br /> <
 strong>Michael Albers</strong> <br /><br />Title: <strong>Synthesis and In
 vestigation of bacterial effector molecules</strong><br /><br /><br />Facu
 lty Examiner: Christian Hackenberger\, FMP Berlin. <br />Supervisor: Chris
 tian Hedberg.<br /><br />Place: Lilla h&ouml\;rsalen\, KBC</p>
DTSTART;TZID=Europe/Stockholm:20160219T100000
DTEND;TZID=Europe/Stockholm:20160219T110000
SUMMARY:Thesis Defence - Michael Albers: Synthesis and Investigation of bac
 terial effector molecules
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/165-general/
 406-thesis-defence-michael-albers-synthesis-and-investigation-of-bacterial
 -effector-molecules.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:<p>Department of Chemistry</p>\n<p>Thesis Defe
 nce<br /><br /> <strong>Michael Albers</strong> <br /><br />Title: <strong
 >Synthesis and Investigation of bacterial effector molecules</strong><br /
 ><br /><br />Faculty Examiner: Christian Hackenberger\, FMP Berlin. <br />
 Supervisor: Christian Hedberg.<br /><br />Place: Lilla h&ouml\;rsalen\, KB
 C</p>
END:VEVENT
BEGIN:VEVENT
UID:20160225T090000UTC-b8d43a@http://www.ucmr.umu.se/
DTSTAMP:20260514T233935Z
CATEGORIES:Events
DESCRIPTION:<p>Friday 26 February\, 10.00 (Note\, change of time) Sal E04\,
  NUS Trapphus R\, 1 stairs down<br />Clinical Microbiology<br />Thesis def
 ence<br />Marie Honn<br /><br />&nbsp\;<br /><strong>Title:&nbsp\; Oxidati
 ve stressresponse hos Francisella tularensis</strong><br />&nbsp\;<br />Fa
 culty Examiner: Andres Melendez\, Colleges of naoscale Science and<br />En
 gineering University of Albany\, Sate University of New York<br />Supervis
 or Anders Sj&ouml\;stedt</p>
DTSTART;TZID=Europe/Stockholm:20160225T100000
DTEND;TZID=Europe/Stockholm:20160225T110000
SUMMARY:Thesis Defence - Marie Honn: Oxidative stressresponse hos Francisel
 la tularensis
URL:http://www.ucmr.umu.se/about-ucmr/events/162-ucmr-calendar/163-events/4
 09-thesis-defence-marie-honn-oxidative-stressresponse-hos-francisella-tula
 rensis.html
X-ALT-DESC;FMTTYPE=TEXT/HTML:<p>Friday 26 February\, 10.00 (Note\, change o
 f time) Sal E04\, NUS Trapphus R\, 1 stairs down<br />Clinical Microbiolog
 y<br />Thesis defence<br />Marie Honn<br /><br />&nbsp\;<br /><strong>Titl
 e:&nbsp\; Oxidative stressresponse hos Francisella tularensis</strong><br 
 />&nbsp\;<br />Faculty Examiner: Andres Melendez\, Colleges of naoscale Sc
 ience and<br />Engineering University of Albany\, Sate University of New Y
 ork<br />Supervisor Anders Sj&ouml\;stedt</p>
END:VEVENT
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