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All scientists and staff members within UCMR (Umeå Centre for Microbial Research) research groups, collaboration partners and researchers with an interest in microbial research and/or infection biology are invited to a day of inspiring research presentations and an excellent opportunity for networking and initiation of multidisciplinary collaborations. The programme will include invited speakers and networking in round table discussion on topics relevant for infection biology research.
1st Arctic Meeting on Clinical Tuberculosis, Umeå 25-26 January, 2018
Welcome to the 1st Arctic Meeting on Clinical Tuberculosis, Umeå The first Arctic Meeting on Clinical Tuberculosis will take place at Norrland University Hospital and is organized by researchers at Umeå University, Infection Clinic / TB Centrum Norr and TBnet. Venue: Bärnstensalen, Norrland University Hospital
World Antibiotics Awareness Week, 13-19 November 2017
WHO campaign 2017: Antibiotics: Handle with care
World Antibiotic Awareness Week (WAAW) aims to increase awareness of global antibiotic resistance and to encourage best practices among the general public, health workers and policy-makers to avoid the further emergence and spread of antibiotic resistance.
Researchers (ca 50 research groups) at MIMS and UCMR work on the understanding of molecular mechanisms of microbial infections. The knowledge could be used to develop new antimicrobial strategies for future treatment of infections and to avoid antibotic resistance.
MIMS Deputy Director Maria Fällman will give a popular science lecture in Swedish language in the series of popular science lectures "lärande luncher" organised by the Norrland University Hospital. Title: "Nya vapen mot seglivade bakterier"
Lessons from bacteria: Novel antimicrobial strategies based on interspecies metabolic cooperation
MIMS- scientist publish in the high-impact Journal of the International Society for Microbial Ecology, ISME.
An important survival strategy in bacteria is the release of toxic substances, which can attack and kill cells and other bacteria. One of these substances are D-amino acids, which are secreted to the environment at high concentrations by very diverse bacteria. D-amino acids interfere with the growth of neighboring competitors thereby improving the chances of producer species to colonize an specific niche. Felipe Cava's research group at The Laboratory for Molecular Infection Medicine Sweden (MIMS) studied the biological effects caused by distinct D-amino acids released by the causative agent of cholera, Vibrio cholerae. The study was performed in collaboration with Miguel A de Pedro, a former visiting professor at Umeå University and investigator at the Centro de Biología Molecular ‘Severo Ochoa’, CSIC in Madrid, Spain.
The scientists found that D-Arginine is a very potent and very broad growth inhibitor of many diverse bacterial species, including pathogenic ones such as Burkholderias, well known for their implication in pulmonary infections and their broad antibiotic resistance.
"We found that D-Arginine is a key environmental factor that controls both fitness and survival of bacterial subpopulations and therefore can modulate the existing biodiversity within an ecological niche" explains Laura Alvarez, postdoctoral researcher who conducted the study.
Alvarez and colleagues found, too, that although all the members of the Vibrionaceae family were resistant to D-arginine, not all of them produce this effector. This behavior suggests that a few vibrios may have evolved to help members of the family in an altruistic cooperation to facilitate prevalence of the entire vibrio in a particular ambient.
Exploring the Complexity of Life by Cryo-Electronmicroscopy
[2017-02-01] Major technical advances has enabled cryo-EM to become a mainstream technique in visualization of macromolecules, which provides the most definitive way to describe their mechanisms of action. The first international cryo-EM symposium in Sweden will take place in Stockholm and Umeå, and present the developments that are shaping this scientific breakthrough. Topics covered include central discoveries in cryo-EM, the most recent methodological developments and applications to central biological questions.